Effectiveness of licorice on Aphthous ulcers in children: a Systematic.

REVIEW QUESTION(S)/ OBJECTIVES The review objective is to identify and synthesise the best available evidence on the effectiveness of daily orally taken licorice gargle on the incidence, duration and severity of canker sore (Aphthous ulcers), in children. Inclusion criteria Types of Participants The review will consider studies which include children (2-12 years of age) with Aphthous Ulcers of either gender. Types of Interventions The review will consider studies where the focus is the effectiveness of daily orally taken licorice with warm water for gargle, as compared with usual care or no treatment. Types of Outcome measures The outcome measures will include: -Incidence of canker sores RAS expressed as the proportion of participants experiencing one or more Aphthous ulcers or expressed as number and size of the ulcer during the study period -Duration of canker sores episodes expressed as the average number of days of canker sores episodes. -As measured using validated pain scales of these RAS canker sores episodes