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A systematic review on the role of extremity skin temperature as a non-invasive marker for hypoperfusion in critically ill adults in the intensive care setting. 系统回顾了在重症监护环境中,四肢皮肤温度作为低灌注危重症成人的非侵入性标志物的作用。
Pub Date : 2012-11-13 DOI: 10.11124/JBISRIR-2012-47
Woo Fong Yeong Brigitte, C. Childs
BACKGROUNDHaemodynamic monitoring is the cornerstone of critical care management. The adequacy of peripheral perfusion has been used as a determinant of cardiovascular system status. Poor cardiac function leads to increased vascular resistance, contributing to reduced tissue perfusion, and it is said to cause a large temperature gradient between the core and the skin. Consequently, skin temperature at the extremities has been proposed as a "proxy" to assess peripheral perfusion. However, this has not been investigated in a systematic way, hence the need for a systematic review of the literature.OBJECTIVESThe objective of this review is to present the best available evidence on extremity skin temperature as a non-invasive marker of hypoperfusion in critically ill adult patients.SEARCH STRATEGYA comprehensive search of major databases was performed to ensure all studies meeting the inclusion criteria were retrieved. The search strategy aimed to find both published and unpublished studies, published in English language, from 1969 to 2010.SELECTION CRITERIARandomised controlled trials, quasi-experimental studies, non-randomised controlled trials, and before and after studies that investigate the role of skin temperature as a marker of hypoperfusion were included. Observational, correlational studies were included due to the lack of studies with high level of evidence.Male and female critically ill adult patients (aged 18 years and above) admitted to the intensive care setting.The review considered studies that evaluate the role of extremity skin temperature monitoring in the diagnosis of hypoperfusion. Skin temperature monitored subjectively via touch or palpation and objectively via skin temperature monitoring devices.Measures of skin temperature (e.g. toe temperature, core-peripheral temperature, etc.) and markers of perfusion (e.g. cardiac output, mean arterial pressure, heart rate, central venous pressure, etc.).CRITICAL APPRAISAL, DATA COLLECTION & DATA SYNTHESISEligibility of papers were assessed independently by the two reviewers. Ten studies were assessed for methodological quality with a modified Critical Appraisal Checklist. After this process, five were selected. A newly-developed data extraction tool was used to gather specific information from the selected studies. Due to the heterogeneity of the studies' methodology, the results of this systematic review were presented in a narrative summary.RESULTSThere were three studies which support the use of extremity skin temperature as a marker of hypoperfusion and two studies which do not support the use. These results reveal the apparent lack of consensus in the studies as to whether or not extremity skin temperature is an accurate and reliable marker of hypoperfusion.CONCLUSIONSThe use of extremity skin temperature as a "proxy" for hypoperfusion cannot be validated or recommended due to the paucity of definitive evidence.The review is unable to provide a definitive re
背景:血流动力学监测是重症监护管理的基石。外周灌注是否充足已被用作心血管系统状态的决定因素。心功能不佳导致血管阻力增加,导致组织灌注减少,据说会导致核心和皮肤之间的温度梯度很大。因此,四肢的皮肤温度被认为是评估周围灌注的“代理”。然而,这还没有被系统地研究过,因此需要对文献进行系统的回顾。目的:本综述的目的是提供关于四肢皮肤温度作为危重成人患者灌注不足的非侵入性标志物的最佳现有证据。检索策略对主要数据库进行全面检索,以确保检索到所有符合纳入标准的研究。搜索策略旨在找到从1969年到2010年以英语发表的已发表和未发表的研究。选择标准:纳入随机对照试验、准实验研究、非随机对照试验以及研究皮肤温度作为低灌注标志作用的前后研究。由于缺乏高水平证据的研究,因此纳入了观察性、相关性研究。入住重症监护室的男性和女性成年危重患者(18岁及以上)。该综述考虑了评估四肢皮肤温度监测在低灌注诊断中的作用的研究。主观上通过触摸或触诊监测皮肤温度,客观上通过皮肤温度监测装置监测皮肤温度。测量皮肤温度(如脚趾温度、核心-外周温度等)和灌注指标(如心输出量、平均动脉压、心率、中心静脉压等)。关键评估,数据收集和数据综合论文的资格由两位审稿人独立评估。使用修改后的关键评估清单评估10项研究的方法学质量。经过这个过程,选出了5个。使用新开发的数据提取工具从选定的研究中收集具体信息。由于研究方法的异质性,本系统综述的结果以叙述性摘要的形式呈现。结果有3项研究支持使用四肢皮肤温度作为低灌注的标志,2项研究不支持使用。这些结果表明,对于四肢皮肤温度是否是低灌注的准确和可靠的标志,研究中明显缺乏共识。结论由于缺乏明确的证据,不能验证或推荐使用四肢皮肤温度作为低灌注的“代理”。该综述无法提供一个明确的建议来指导该领域的临床实践。尽管如此,四肢皮肤温度的评估可能是可行的,在普通病房识别患者的风险,因为它易于使用和非侵入性。应该进行更高质量的研究,以确定四肢皮肤温度是否可以作为危重成人灌注不足的非侵入性标志物。
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引用次数: 2
Effectiveness of interventions for the assessment and prevention of falls in adult psychiatric patients: A systematic review. 评估和预防成人精神病患者跌倒的干预措施的有效性:系统综述。
Pub Date : 2012-02-15 DOI: 10.11124/01938924-201210090-00001
Changqing Xu, Tan Xiang, Ning Audrey, S. Loh, Wan Ting Shanel, J. Tan, R. Parasuram
Review Questions/Objectives The objective of this review is to identify the best available evidence for the effectiveness of risk assessment tools designed to assess fall risk and reduce the incidence of falls in adult psychiatric patients. Specifically, the review seeks to answer the following:  How effective are the risk assessment tools for falls in reducing fall rates in adult psychiatric patients?  How effective are the interventions undertaken in reducing the incidence of falls among adult psychiatric patients?  What are the most common characteristics of adult psychiatric patients who fall? Inclusion Criteria Types of Participants This review will consider all studies that include adults (19 to 64 years) diagnosed with mental illness according to any editions of the diagnostic manual of ICD (International Statistical Classification of Diseases and Related Health Problems), or DSM (Diagnostic and Statistical Manual of Mental Disorders). Types of Interventions This review will consider all studies that include interventions that assessed or minimized the risk of falling in adult psychiatric patients. Types of Outcome Measures The outcome measure of interest will be the number of patient falls during hospitalization
本综述的目的是为评估成人精神病人跌倒风险和减少跌倒发生率的风险评估工具的有效性确定现有的最佳证据。风险评估工具在降低成人精神病患者跌倒率方面的效果如何?在降低成人精神病患者跌倒发生率方面采取的干预措施有多有效?成人精神病患者摔倒最常见的特征是什么?纳入标准参与者类型本综述将考虑所有根据ICD(国际疾病及相关健康问题统计分类)或DSM(精神障碍诊断与统计手册)诊断为精神疾病的成人(19至64岁)的研究。干预措施的类型本综述将考虑所有包括评估或最小化成年精神病患者跌倒风险的干预措施的研究。结果测量的类型感兴趣的结果测量将是住院期间患者跌倒的次数
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引用次数: 1
The impact of knowledge and beliefs on adherence to cardiac rehabilitation programs in patients with heart failure: A systematic review. 知识和信念对心力衰竭患者心脏康复计划依从性的影响:系统综述。
Pub Date : 2012-02-09 DOI: 10.11124/JBISRIR-2012-53
T. Jasmine, Sally Chan Wai‐Chi, D. Hegney
BACKGROUNDHeart failure is a global health problem which affects a large percentage of the older population. Cardiac rehabilitation programs have been implemented to aid patients in successfully managing their heart condition. However, non-adherence to cardiac rehabilitation programs is common in this group of patients. This results in higher morbidity and mortality rates, rehospitalisation and ultimately higher healthcare costs. There is a need to have a better understanding of the impact that knowledge and beliefs have on patients' adherence levels, so that healthcare providers can implement appropriate strategies to promote their adherence.OBJECTIVESThis review aimed to establish the best evidence regarding the impact of knowledge and beliefs on adherence to cardiac rehabilitation programs in patients with heart failure; and to make recommendations for healthcare practice and future research.INCLUSION CRITERIAPatients above the age of 18, who had been diagnosed with heart failure and had been admitted to a cardiac rehabilitation program in inpatient or outpatient settings.This review considered studies that evaluated the impact of heart failure patients' knowledge and beliefs of their disease, medication, diet, exercise and other lifestyle change recommendations, on their adherence to cardiac rehabilitation programs.Heart failure patients' knowledge, beliefs and adherence toward their medication regime, low-sodium diet, exercise, and other lifestyle change recommendations.Quantitative study designs published in the English language, up to December 2010 were considered for inclusion.SEARCH STRATEGYUsing a three-step search strategy, the following databases were assessed: CINAHL, PubMed, SCOPUS, Web of Science, OvidSP, MDConsult, ScienceDirect, Sociological Abstracts, Mosby's Nursing Consult, Mednar and TRIP.METHODOLOGICAL QUALITYTwo independent reviewers assessed each paper for methodological validity prior to inclusion in the review using standardised critical appraisal instruments from the Joanna Briggs Institute.DATA EXTRACTIONInformation was extracted by two independent reviewers, from each paper using the standardised data extraction tool from the Joanna Briggs Institute.DATA SYNTHESISThe findings are presented in narrative form, as statistical pooling was not possible, due to the different instruments used in measuring the outcomes.RESULTSTwelve quantitative studies were included in this review (one RCT, one pre-test/post-test single group study, and ten descriptive studies). The present findings suggest that the relationship between knowledge and adherence is unclear. However, patient beliefs on medication, symptom monitoring, illness and control were found to have stronger associations of adherence to cardiac rehabilitation programs.Implications for practice Healthcare institutions need to provide adequate support for patients with heart failure; individualise adherence-enhancing interventions to cater for v
背景:心力衰竭是一个全球性的健康问题,影响了很大比例的老年人口。心脏康复计划已经实施,以帮助患者成功地控制他们的心脏状况。然而,不遵守心脏康复计划在这组患者中很常见。这导致更高的发病率和死亡率、再住院率和最终更高的医疗费用。有必要更好地了解知识和信念对患者依从性水平的影响,以便医疗保健提供者能够实施适当的策略来促进患者的依从性。目的:本综述旨在建立关于知识和信念对心力衰竭患者心脏康复计划依从性影响的最佳证据;并为医疗实践和未来的研究提出建议。纳入标准:年龄在18岁以上,被诊断为心力衰竭并在住院或门诊接受心脏康复计划的患者。本综述考虑了评估心力衰竭患者对其疾病的认识和信念、药物、饮食、运动和其他生活方式改变建议对他们坚持心脏康复计划的影响的研究。心力衰竭患者对药物治疗、低钠饮食、运动和其他生活方式改变建议的认识、信念和依从性。截至2010年12月,以英语发表的定量研究设计被纳入考虑范围。检索策略采用三步检索策略,对以下数据库进行评估:CINAHL、PubMed、SCOPUS、Web of Science、OvidSP、MDConsult、ScienceDirect、Sociological Abstracts、Mosby’s Nursing Consult、Mednar和TRIP。方法学质量在纳入研究之前,两名独立的审稿人使用乔安娜布里格斯研究所的标准化关键评估工具评估了每篇论文的方法学有效性。数据提取信息由两名独立审稿人使用Joanna Briggs研究所的标准化数据提取工具从每篇论文中提取。数据综合由于在测量结果时使用了不同的工具,因此不可能进行统计汇总,因此研究结果以叙述形式呈现。结果本综述共纳入12项定量研究(1项随机对照试验、1项测试前/测试后单组研究和10项描述性研究)。目前的研究结果表明,知识与依从性之间的关系尚不清楚。然而,患者对药物、症状监测、疾病和控制的信念与心脏康复计划的依从性有更强的关联。对实践的启示医疗机构需要为心力衰竭患者提供足够的支持;个性化增强依从性的干预措施,以满足不同患者的需求;并致力于赋予病人权力。未来的定量研究应该进行,以调查知识和信念之间的关系,确定它们对依从性的综合影响,并检查用于提高患者知识和信念的策略的有效性。定量和定性研究也可用于确定与患者知识、信念和依从性相关的因素。
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引用次数: 3
A systematic review of the effectiveness of patient-centred care on emergency room visits, hospitalizations, unscheduled sick clinic visits, and missed school days for children with asthma. 对以患者为中心的护理在急诊室就诊、住院、计划外门诊就诊和哮喘儿童缺课日等方面的有效性进行系统回顾。
Pub Date : 2012-01-01 DOI: 10.11124/01938924-201109481-00017
C. Barnes, Eugene Cauvin, Meral Duran-Kim, Lisa A Montalbano, M. Londrigan
BACKGROUND Childhood asthma is a major clinical concern worldwide, associated with increased levels of morbidity and missed school days, placing a heavy strain on healthcare systems in terms of both financial cost and hospital usage. The utilization of suitable therapy, written treatment plans, and patient education have been the focus of many interventional strategies to improve outcomes. OBJECTIVES The objective of this systematic review was to identify, appraise, and synthesize the best available evidence to determine the effectiveness of patient-centred care on emergency room visits, hospitalizations, unscheduled primary care provider visits, and missed school days in the management of children with asthma. INCLUSION CRITERIA The review considered studies that included children from newborn to seventeen years of age with a clinical diagnosis of asthma who were being treated in an outpatient healthcare setting, regardless of severity, previous treatments, co-morbidities, and ethnic or socioeconomic backgrounds.The review considered studies that evaluated the effects of the patient-centred care model in the management of children with asthma.This review considered studies that included the following outcome measures: emergency room (ER) visit rates, hospital admission rates, unscheduled primary care provider visit rates, and number of missed school days per year associated with asthma symptoms.The review considered any randomized controlled trials (RCTs) and quasi-experimental clinical controlled trials (CCTs). SEARCH STRATEGY The search strategy examined both published and unpublished studies from 1970 to present that were written in the English language. The databases searched included: Medline, CINAHL, The Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE, Academic Search Premier, PsycINFO, Healthsource Nursing/Academic edition, and PubMed. A grey literature search was performed. METHODOLOGICAL QUALITY Papers that met the inclusion criteria were assessed by two independent reviewers for methodological validity prior to inclusion in the review, using the standardized critical appraisal instrument from Joanna Briggs Institute. DATA EXTRACTION Data was extracted using the standardized data extraction tool from the JBI - MAStARI. DATA SYNTHESIS Statistical pooling was not possible due to heterogeneity of the studies; therefore the findings were presented in a narrative form. RESULTS Ten studies (nine RCTs and one quasi-experimental CCT) were included in the review. Nine of the studies looked at the outcome of hospitalizations of which five showed a decline in hospitalizations when a patient-centred care model was used; two were significant with p values of <0.05 and <0.001. Eight studies looked at the outcome of ER visits. Six of these reported a decline in ER visits after the intervention of which three were significant with p values of <0.001, <0.05 and <0.05. Six studies looked at missed school days of which one s
儿童哮喘是世界范围内的一个主要临床问题,与发病率增加和缺课有关,在财务成本和医院使用方面给卫生保健系统带来了沉重的压力。使用合适的治疗方法、书面治疗计划和患者教育一直是许多干预策略的重点,以改善结果。本系统综述的目的是识别、评价和综合现有的最佳证据,以确定以患者为中心的护理在哮喘儿童的急诊室就诊、住院、未安排的初级保健提供者就诊和缺课日管理中的有效性。纳入标准:本综述纳入了从新生儿到17岁临床诊断为哮喘且在门诊医疗机构接受治疗的儿童,无论其严重程度、既往治疗、合并症、种族或社会经济背景如何。该综述考虑了评估以患者为中心的护理模式在哮喘儿童管理中的效果的研究。本综述考虑了包括以下结局指标的研究:急诊室(ER)就诊率、住院率、未安排的初级保健提供者就诊率以及每年与哮喘症状相关的缺课天数。本综述纳入了所有随机对照试验(rct)和准实验临床对照试验(cct)。检索策略检索策略检查了从1970年至今用英语撰写的已发表和未发表的研究。检索的数据库包括:Medline、CINAHL、Cochrane中央对照试验注册库(Central)、EMBASE、Academic Search Premier、PsycINFO、Healthsource Nursing/Academic edition和PubMed。进行灰色文献检索。方法学质量符合纳入标准的论文在纳入之前由两名独立的审稿人评估方法学有效性,使用乔安娜布里格斯研究所的标准化关键评估工具。数据提取使用标准化数据提取工具从JBI - MAStARI中提取数据。由于研究的异质性,无法进行统计汇总;因此,调查结果以叙述形式提出。结果共纳入10项研究(9项rct和1项准实验CCT)。其中九项研究考察了住院治疗的结果,其中五项研究表明,当采用以患者为中心的护理模式时,住院率有所下降;其中2例显著性差异,p值分别<0.05和<0.001。八项研究着眼于急诊室就诊的结果。其中6个报告干预后急诊就诊次数下降,其中3个显著,p值分别为<0.001、<0.05和<0.05。六项研究考察了缺课天数,其中一项研究在干预后显示了显著差异(p< 0.01),而四项研究报告了缺课天数的减少,但没有报告显著性。四项研究调查了未安排的初级保健提供者就诊情况,其中一项研究报告干预后有显著差异(p < 0.05)。结论:本综述的研究结果表明,当护理以患者为中心、哮喘护理计划个体化并纳入教育成分时,哮喘儿童的急诊就诊、住院、未安排的初级保健提供者就诊和缺课日均可产生积极的结果。本综述支持以患者为中心的儿科哮喘护理,注重相互合作、教育和临床支持。本综述强调需要继续研究,以确定以患者为中心的干预措施的最有效方式、性质和持续时间,以改善哮喘儿童的预后。
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引用次数: 2
A systematic review of differences between brain temperature and core body temperature in adult patients with severe traumatic brain injury. 成人严重创伤性脑损伤患者脑温度和核心体温差异的系统综述。
Pub Date : 2012-01-01 DOI: 10.11124/01938924-201210240-00001
Kueh Wern Lunn, C. Childs
BACKGROUND Studies have shown that temperature at the extremes of the thermoregulatory physiological range, commensurate with a clinical diagnosis of hypothermia (at the lower end) and hyperthermia or fever (at the upper end) increase the risk of a poor neurological outcome and contribute to higher mortality. The tissue most at risk is nervous tissue. That said however, precise measurement of cerebral tissue temperature is seldom made during routine clinical care. More commonly, brain temperature is estimated from measurements of core body temperature. Different measurement sites are frequently used as a proxy or 'surrogate' for brain temperature. Knowing whether the assumption that brain temperature can be reliably represented by core body temperature is important because it will help healthcare professionals to deliver appropriate treatment when a rise (or fall) in brain temperature beyond the 'normal' range is suspected. OBJECTIVES This systematic review focused on whether brain temperature is higher, lower, or the same as core body temperature in patients with severe traumatic brain injury. INCLUSION CRITERIA This review considered studies that include male and female patients, aged 15 years and above, admitted to an adult Intensive Care Unit, with the diagnosis of severe traumatic brain injury, with a Glasgow Coma Scale score of less than eight, and who require brain temperature monitoring.The review considered studies that measured brain temperature and core body temperature.The agreement of core body temperature as a surrogate measure for brain temperature in adult patients with severe traumatic brain injury.The review considered any randomised controlled trials. In the absence of randomised controlled trials, other research designs such as non-randomised controlled trials, before and after studies, cohort studies, case-control studies and descriptive studies were considered for inclusion. SEARCH STRATEGY Utilising a three-step search strategy, articles published in English from the years 1980 to 2010 from the following databases were searched: CINAHL, PubMed, Scopus, Web of Science, Science Direct, Ovid SP, Mednar and ProQuest Dissertations & Theses Database. METHODOLOGICAL QUALITY Two reviewers independently reviewed studies using the appraisal tool developed by the authors, as the critical appraisal instrument provided by the Joanna Briggs Institute was not suitable for this systematic review. DATA EXTRACTION Data were extracted using the extraction tool developed by the authors, as the data extraction instrument provided by the Joanna Briggs Institute was not suitable for this systematic review. DATA SYNTHESIS A narrative summary of all findings was presented as statistical pooling was not possible. RESULTS Thirty-three studies were identified through the keywords search using the databases listed above. Eight studies were included in this systematic review after the assessment of methodological quality. Eleven temperatur
研究表明,在体温调节生理范围的极端温度,与临床诊断的低体温(低端)和高体温或发烧(高端)相当,会增加神经系统预后不良的风险,并导致更高的死亡率。最危险的组织是神经组织。然而,在常规临床护理中,很少进行脑组织温度的精确测量。更常见的是,大脑温度是通过测量核心体温来估计的。不同的测量点经常被用作大脑温度的代理或“代理”。了解大脑温度是否可以由核心体温可靠地表示的假设是很重要的,因为它将帮助医疗保健专业人员在怀疑大脑温度上升(或下降)超出“正常”范围时提供适当的治疗。目的:本系统综述关注重型颅脑损伤患者的脑温度是否高于、低于或与核心体温相同。纳入标准本综述纳入的研究包括年龄在15岁及以上、被诊断为严重外伤性脑损伤、格拉斯哥昏迷评分低于8分、需要进行脑温度监测的成人重症监护病房收治的男性和女性患者。该综述考虑了测量大脑温度和核心体温的研究。核心体温作为成人重型颅脑损伤患者脑温度替代测量的一致性。该综述考虑了所有随机对照试验。在没有随机对照试验的情况下,其他研究设计,如非随机对照试验、前后研究、队列研究、病例对照研究和描述性研究也被考虑纳入。检索策略:采用三步检索策略,检索1980 - 2010年在以下数据库中发表的英文论文:CINAHL、PubMed、Scopus、Web of Science、Science Direct、Ovid SP、Mednar和ProQuest博士论文与论文数据库。方法学质量:两位审稿人使用作者开发的评估工具独立审查了研究,因为乔安娜布里格斯研究所提供的关键评估工具不适合本系统评价。数据提取使用作者开发的提取工具提取数据,因为Joanna Briggs研究所提供的数据提取工具不适合本系统综述。数据综合由于不可能进行统计汇总,因此提出了所有调查结果的叙述性摘要。结果利用上述数据库进行关键词检索,共筛选出33项研究。在方法学质量评估后,本系统综述纳入了8项研究。在8项研究中确定了11种温度比较。大多数对比显示,大脑温度高于身体核心温度。然而,三项研究表明,核心温度高于脑温度,特别是当患者的脑温度降至36℃以下时。结论核心体温不能预测脑温。本综述中没有一个核心体温部位可以代替脑温度。同时监测脑和体温在治疗重型颅脑损伤患者中具有重要意义。由于体温不能准确反映脑温度,重症监护病房收治的严重创伤性脑损伤患者应同时监测脑温度和核心温度。未来的研究应该集中在更大的样本量和标准化的大脑和核心温度测量点上。
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引用次数: 1
Identifying and reducing the incidence of post discharge Venous Thromboembolism (VTE) in orthopaedic patients: a systematic review. 识别和减少骨科患者出院后静脉血栓栓塞(VTE)的发生率:一项系统综述。
Pub Date : 2012-01-01 DOI: 10.11124/jbisrir-2012-315
P. McLiesh, R. Wiechula
BACKGROUND The risk of venous thromboembolism for orthopaedic patients is often high due to the length of surgery, damage from trauma to bone and soft tissues and lengthy periods of immobility or reduced mobility. Although venous thromboembolism occurs mainly in inpatients a significant number of patients develop venous thromboembolism post discharge OBJECTIVES: To synthesise the best available evidence on strategies that effectively reduce post discharge venous thromboembolism in orthopaedic patients. INCLUSION CRITERIA Patients regardless of age, gender or co-morbidities that have been admitted with an acute orthopaedic injury (unplanned) or a planned orthopaedic surgery/procedure and then followed up after discharge. Only papers describing the incidence and prophylaxis treatment used in non-Asian patients were considered for inclusion.Any interventions of combinations of chemoprophylaxis and/or mechanical prophylaxis to prevent venous thromboembolism incidence extending beyond hospital admission.Outcomes included diagnosis of venous thromboembolism following an orthopaedic admission/surgery for up to 6 months post discharge and the incidence of any significant bleeding or death related to venous thromboembolism or haemorrhage.The review considered any randomised controlled trials; in the absence of RCTs other research designs, such as non-randomised controlled trials and before and after studies, were considered SEARCH STRATEGY: Search strategy considered only papers in English from 2000 to March 2012. METHODOLOGICAL QUALITY Papers selected for retrieval were assessed using standardised critical appraisal instruments from the Joanna Briggs Institute. DATA COLLECTION Data was extracted from the studies using the standardised Johanna Briggs Institute data extraction form. DATA SYNTHESIS Of the included studies none matched methodology, treatment or comparator that allowed meta-analysis. The results were therefore presented in a narrative form and were structured using patient population, then intervention and then analysis of results. RESULTS 20 articles were included in the systematic review. The overall incidence of post discharge venous thromboembolism in orthopaedic patients is not possible to determine due to the variability in reporting criteria and poor follow-up. Use of Low Molecular Weight Heparins was generally shown to be effective in preventing venous thromboembolism. The new generation Factor Xa inhibitors were shown to improve venous thromboembolism prevention however had a slightly higher risk of bleeding. There was limited high level research presented to allow effective assessment of aspirin and/or mechanical compression devices. CONCLUSIONS Prevention of post discharge venous thromboembolism is complex due to the number of variables that can influence its occurrence. The risk of post discharge venous thromboembolism varies among different patient populations so consideration must be given to matching the risk for ea
骨科患者发生静脉血栓栓塞的风险通常很高,这是由于手术时间长、骨骼和软组织损伤以及长时间的不活动或活动能力降低。尽管静脉血栓栓塞主要发生在住院患者中,但相当数量的患者在出院后发生静脉血栓栓塞目的:综合现有的最佳证据,有效减少骨科患者出院后静脉血栓栓塞的策略。纳入标准:因急性骨科损伤(计划外)或计划骨科手术/手术而入院并出院后随访的患者,不论年龄、性别或合并症。只有描述非亚洲患者发病率和预防性治疗的论文才被纳入考虑。任何化学预防和/或机械预防相结合的干预措施,以防止住院后静脉血栓栓塞的发生。结果包括出院后6个月骨科住院/手术后静脉血栓栓塞的诊断,以及与静脉血栓栓塞或出血相关的任何重大出血或死亡的发生率。该综述考虑了所有随机对照试验;在没有随机对照试验的情况下,考虑其他研究设计,如非随机对照试验和前后研究。检索策略:检索策略仅考虑2000年至2012年3月的英文论文。使用乔安娜布里格斯研究所的标准化关键评估工具对选择用于检索的方法学质量文件进行评估。数据收集使用标准化的约翰娜布里格斯研究所数据提取表从研究中提取数据。在纳入的研究中,没有匹配的方法学、治疗或比较物允许进行meta分析。因此,结果以叙述的形式呈现,并使用患者群体,然后干预,然后分析结果来构建。结果20篇文献被纳入系统评价。骨科患者出院后静脉血栓栓塞的总体发生率由于报告标准的差异和随访不良而无法确定。使用低分子肝素通常被证明是有效的预防静脉血栓栓塞。新一代Xa因子抑制剂被证明可以改善静脉血栓栓塞的预防,但出血的风险略高。有关阿司匹林和/或机械压迫装置的有效评估的高水平研究有限。结论静脉血栓栓塞的预防是复杂的,影响其发生的因素很多。出院后静脉血栓栓塞的风险在不同的患者群体中有所不同,因此必须考虑将这些群体的风险与可用的干预措施相匹配。对于高风险的骨科患者,如大关节置换术和股骨骨折患者,应考虑使用低分子肝素,并在出院后30天内继续使用,但必须考虑人群和个人发生静脉血栓栓塞和出血的风险。在未来的研究设计中,必须考虑以下因素:足够的随访时间,以及衡量出院后静脉血栓栓塞发生率的标准化标准。
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引用次数: 2
The psychometric properties, feasibility and utility of behavioural-observation methods in pain assessment of cognitively impaired elderly people in acute and long-term care: A systematic review. 行为观察方法在急性和长期护理中评估认知障碍老年人疼痛的心理测量特性、可行性和实用性:系统综述。
Pub Date : 2012-01-01 DOI: 10.11124/jbisrir-2012-62
Siok Qi, J. Diane, D. Kay
BACKGROUND The key factor to improving pain management for cognitively impaired elderly patients is accurate pain assessment. Behavioural-observation methods are required for individuals who cannot communicate their pain verbally. A thorough understanding of the key components of behavioural pain assessment and the use of valid and reliable behavioural pain assessment tools would enhance the assessment of pain in this vulnerable population. OBJECTIVES To identify the key components involved in behavioural pain assessment in cognitively impaired elderly people and to analyse the reported psychometric properties, feasibility and utility of behavioural pain assessment tools. SELECTION CRITERIA Studies using descriptive, correlation and comparative designs were included.Cognitively impaired elderly people older than 65 years in aged care, acute care or nursing home settings were included.Components measured in behavioural pain assessment; psychometric properties, feasibility and utility of behavioural pain assessment tools used to assess pain in cognitively impaired elderly people in acute or long-term care settings.Identification of behavioural criteria for assessment of pain and investigation of any aspect of the psychometric properties of behavioural pain assessment tools. SEARCH STRATEGY An initial limited search of MEDLINE and CINAHL to find published studies between 1990 to 2010 in the English Language was undertaken, following an analysis of the text words contained in the title and abstract. A second search using all identified keywords and index terms was undertaken and extended to a further seven relevant databases. Thirdly, the reference lists of all identified reports and articles were searched for additional studies. METHODOLOGICAL QUALITY Studies selected for retrieval were assessed for inclusion by two independent reviewers for methodological validity using the Critical Appraisal Tool for Psychometric Studies adapted from Fallon, Westaway, and Moloney1. DATA EXTRACTION Quantitative data were extracted from included studies using the Data Extraction Tool for Psychometric Studies adapted from Fallon, Westaway, and Mahoney1. DATA SYNTHESIS As statistical pooling was not possible, evidence in relation to psychometric properties, was analysed and presented in narrative summary. RESULTS Twenty three studies were included in the review. No tool has been found suitable for use across both acute and long-term care settings. Nevertheless, three tools show the most promising outcomes and potential for use. CONCLUSIONS Although behavioural measures may inform healthcare providers on the presence of pain in an individual, they do not provide information about the aetiology of pain. Hence, pain assessment should not depend solely on behavioural observation conducted using standardised behavioural pain assessment tools, but regarded as an essential component of a multifaceted approach to pain assessment. Clinicians may select tools wh
背景:准确的疼痛评估是改善老年认知障碍患者疼痛管理的关键因素。对于不能用语言表达痛苦的人,需要行为观察方法。彻底了解行为疼痛评估的关键组成部分,并使用有效可靠的行为疼痛评估工具,将加强对这一弱势群体疼痛的评估。目的识别认知障碍老年人行为疼痛评估的关键成分,分析已有的行为疼痛评估工具的心理测量特性、可行性和实用性。选择标准采用描述性、相关性和比较性设计的研究纳入。老年人护理、急症护理或养老院环境中65岁以上的认知障碍老年人也包括在内。行为疼痛评估中测量的成分;用于评估急性或长期护理环境中认知受损老年人疼痛的行为疼痛评估工具的心理测量学特性、可行性和实用性。确定疼痛评估的行为标准,并调查行为疼痛评估工具的心理测量特性的任何方面。在对标题和摘要中包含的文本词进行分析之后,对MEDLINE和CINAHL进行了初步的有限搜索,以查找1990年至2010年间发表的英语研究。使用所有确定的关键字和索引词进行了第二次搜索,并扩展到另外七个相关数据库。第三,在所有确定的报告和文章的参考文献列表中搜索其他研究。入选研究的方法学质量由两名独立评审员评估纳入研究的方法学有效性,使用心理测量学关键评估工具(改编自Fallon、Westaway和moloney) 1。数据提取使用心理测量学数据提取工具(改编自Fallon、Westaway和mahoney)从纳入的研究中提取定量数据。数据综合由于统计汇集是不可能的,与心理测量特性有关的证据被分析并在叙述摘要中提出。结果共纳入23项研究。没有发现适合在急性和长期护理环境中使用的工具。然而,有三种工具显示出最有希望的结果和使用潜力。结论:尽管行为测量可以告知医疗保健提供者个体疼痛的存在,但它们不能提供有关疼痛病因的信息。因此,疼痛评估不应仅仅依赖于使用标准化行为疼痛评估工具进行的行为观察,而应被视为疼痛评估多方面方法的重要组成部分。临床医生可以选择显示有希望的质量的工具,并在各自的临床环境和人群中进行试点。特别是,MPS、PACSLAC和PAINAD被推荐用于急性和长期护理环境中有认知障碍的老年人。有几种工具有望用于急性或长期护理环境。这些工具需要修改工具以加强其心理测量特性。而不是开发新的工具,修改现有的工具,并对其进行进一步的心理测量评估,可以提供更多的证据,以证明其心理测量的性质。
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引用次数: 9
Prevalence and risk factors associated with spinal pain in adolescent computer users: a systematic review. 青少年电脑使用者脊柱疼痛的患病率及相关危险因素:一项系统综述。
Pub Date : 2012-01-01 DOI: 10.11124/01938924-201008161-00018
Yi-Liang Kuo, Ling-Ling Lee
BACKGROUND Increased computer use has been suggested as a contributing factor for a rapid increase in the prevalence of neck and back pain in adolescents in the late 1990s and the beginning of 2000. OBJECTIVE The overall objective of this review was to synthesise the best available evidence on the estimates of prevalence of, and risk factors associated with, spinal discomfort in adolescent computer users. INCLUSION CRITERIA This review considered cross-sectional, case-control, or cohort studies. Studies were considered for inclusion if they reported either prevalence or risk factors associated with spinal pain in adolescents aged between 13 and 18 years using computer in school or at home. SEARCH STRATEGY The search included The Cochrane Library, JBI Library of Systematic Reviews, PEDro, MEDLINE, CINAHL, Web of Science, ERIC, PsycINFO, EMBASE, and CEPS. The grey literature was also searched. The search was limited to English and Chinese language papers, and spanned from the inception of each database to May 2011. METHODOLOGICAL QUALITY Two review authors independently evaluated the methodological quality of the included studies using the standardised Joanna Briggs Institute instruments. DATA EXTRACTION Data was extracted using the standardised Joanna Briggs Institute data extraction form. DATA SYNTHESIS Meta-analysis was not appropriate because there was considerable heterogeneity between studies. The findings were summarised in tables and in narrative form. RESULTS Seven studies were included in this review: three studies were carried out in Finland, two in the USA, one in Sweden, and one in South Africa. There was marked variability in the period prevalence data across different studies: 15-60% for cervical pain and 12-53% for lumbar pain. None of the reviewed studies reported the confidence intervals for prevalence estimate. Four studies investigated the association between the duration of computer use and cervical pain, two studies for lumbar pain and none for thoracic pain. Positive associations between the duration of computer use and cervical pain were found in three out of four studies, with the odds ratio ranged from 1.3 (95% CI 1.1 to 1.6) to 2.3 (95% CI 1.5 to 3.6). One study found that weekly internet use greater than 42 hours predicted the occurrence of lumbar pain, and the odds ratio was 1.9 with 95% CI of 1.1 to 3.4. The other study reported non-significant association without providing statistical evidence. CONCLUSION This systematic review suggests a relatively high prevalence of spinal pain in adolescents. The cervical spine region appears to be more prone to musculoskeletal pain than the lumbar or thoracic regions. Cervical spine pain was statistically significantly associated with duration of computer use, however the odds ratio may be too small to be considered clinical significant. There is conflicting evidence on the association with duration of computer use and lumbar pain and no evidence for thoracic spine
背景:在20世纪90年代末和2000年初,电脑使用的增加被认为是青少年颈部和背部疼痛患病率迅速增加的一个因素。目的:本综述的总体目标是综合现有的关于青少年电脑用户脊柱不适患病率和相关危险因素的最佳证据。纳入标准:本综述考虑了横断面、病例对照或队列研究。如果研究报告了在学校或家中使用电脑的13至18岁青少年脊柱疼痛的患病率或相关风险因素,则考虑纳入研究。检索策略检索包括Cochrane Library、JBI Library of Systematic Reviews、PEDro、MEDLINE、CINAHL、Web of Science、ERIC、PsycINFO、EMBASE和cceps。灰色文献也被搜索。检索仅限于英文和中文论文,时间跨度从每个数据库建立之初到2011年5月。方法学质量两位综述作者使用标准化的Joanna Briggs研究所仪器独立评估纳入研究的方法学质量。数据提取使用标准化的乔安娜布里格斯研究所数据提取表提取数据。数据综合meta分析不合适,因为研究之间存在相当大的异质性。调查结果以表格和叙述形式加以总结。结果本综述纳入7项研究:3项研究在芬兰进行,2项在美国进行,1项在瑞典进行,1项在南非进行。不同研究的期间患病率数据存在显著差异:颈痛为15-60%,腰痛为12-53%。所审查的研究均未报告患病率估计的置信区间。四项研究调查了电脑使用时间与颈椎疼痛之间的关系,两项研究调查了腰痛,没有研究调查胸痛。四项研究中有三项发现电脑使用时间与颈椎疼痛呈正相关,比值比从1.3 (95% CI 1.1 ~ 1.6)到2.3 (95% CI 1.5 ~ 3.6)。一项研究发现,每周上网超过42小时预示着腰痛的发生,比值比为1.9,95% CI为1.1至3.4。另一项研究报告无显著相关性,但没有提供统计证据。结论:本系统综述提示青少年脊柱疼痛的患病率较高。颈椎区域似乎比腰椎或胸椎区域更容易发生肌肉骨骼疼痛。颈椎疼痛与使用电脑的时间长短有统计学上的显著相关性,但比值比可能太小,不足以被认为具有临床意义。关于电脑使用时间与腰椎疼痛的关系,有相互矛盾的证据,而胸椎没有证据。实践意义脊柱疼痛在青少年中相对较高的患病率突出了预防和治疗策略的必要性。研究意义需要进一步的研究,最好是利用身体检查进行前瞻性队列研究,以更严格地调查青少年使用电脑和脊柱疼痛的问题。有必要在亚洲或发展中国家进行更多的研究,以反映可能影响电脑接触量及其对青少年电脑用户肌肉骨骼健康的潜在影响的任何文化或社会经济差异。
{"title":"Prevalence and risk factors associated with spinal pain in adolescent computer users: a systematic review.","authors":"Yi-Liang Kuo, Ling-Ling Lee","doi":"10.11124/01938924-201008161-00018","DOIUrl":"https://doi.org/10.11124/01938924-201008161-00018","url":null,"abstract":"BACKGROUND Increased computer use has been suggested as a contributing factor for a rapid increase in the prevalence of neck and back pain in adolescents in the late 1990s and the beginning of 2000. OBJECTIVE The overall objective of this review was to synthesise the best available evidence on the estimates of prevalence of, and risk factors associated with, spinal discomfort in adolescent computer users. INCLUSION CRITERIA This review considered cross-sectional, case-control, or cohort studies. Studies were considered for inclusion if they reported either prevalence or risk factors associated with spinal pain in adolescents aged between 13 and 18 years using computer in school or at home. SEARCH STRATEGY The search included The Cochrane Library, JBI Library of Systematic Reviews, PEDro, MEDLINE, CINAHL, Web of Science, ERIC, PsycINFO, EMBASE, and CEPS. The grey literature was also searched. The search was limited to English and Chinese language papers, and spanned from the inception of each database to May 2011. METHODOLOGICAL QUALITY Two review authors independently evaluated the methodological quality of the included studies using the standardised Joanna Briggs Institute instruments. DATA EXTRACTION Data was extracted using the standardised Joanna Briggs Institute data extraction form. DATA SYNTHESIS Meta-analysis was not appropriate because there was considerable heterogeneity between studies. The findings were summarised in tables and in narrative form. RESULTS Seven studies were included in this review: three studies were carried out in Finland, two in the USA, one in Sweden, and one in South Africa. There was marked variability in the period prevalence data across different studies: 15-60% for cervical pain and 12-53% for lumbar pain. None of the reviewed studies reported the confidence intervals for prevalence estimate. Four studies investigated the association between the duration of computer use and cervical pain, two studies for lumbar pain and none for thoracic pain. Positive associations between the duration of computer use and cervical pain were found in three out of four studies, with the odds ratio ranged from 1.3 (95% CI 1.1 to 1.6) to 2.3 (95% CI 1.5 to 3.6). One study found that weekly internet use greater than 42 hours predicted the occurrence of lumbar pain, and the odds ratio was 1.9 with 95% CI of 1.1 to 3.4. The other study reported non-significant association without providing statistical evidence. CONCLUSION This systematic review suggests a relatively high prevalence of spinal pain in adolescents. The cervical spine region appears to be more prone to musculoskeletal pain than the lumbar or thoracic regions. Cervical spine pain was statistically significantly associated with duration of computer use, however the odds ratio may be too small to be considered clinical significant. There is conflicting evidence on the association with duration of computer use and lumbar pain and no evidence for thoracic spine","PeriodicalId":91723,"journal":{"name":"JBI library of systematic reviews","volume":"10 45 1","pages":"2906-2943"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63414932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Supporting trail-blazing: A systematic review of the factors that facilitate or inhibit the implementation of new nursing roles: the experiences of UK consultant nurses. 支持开拓:促进或抑制实施新的护理角色的因素的系统审查:英国咨询护士的经验。
Pub Date : 2012-01-01 DOI: 10.11124/jbisrir-2009-542
Georgina Hourahane, Nicola West, R. Barnes, S. Rees, A. Bowyer, J. Dundon, D. Allen
BACKGROUND If emerging 'trail-blazers', such as the consultant nurse, are to be successful in developing and sustaining new ways of working then factors that support or inhibit new role developments need identification. There is a growing body of evaluative and anecdotal evidence about the experience of consultant nurses since the introduction of the role in the UK thirteen years ago. OBJECTIVE To synthesise the evidence on the experiences of UK consultant nurses in implementing a new role in order to identify inhibitors and facilitators of role development. INCLUSION CRITERIA This review sought qualitative and mixed methodology studies that yielded qualitative data about the phenomenon of interest, together with narrative opinion papers i.e. consultant nurses' experiences of role development. SEARCH STRATEGY The search in 14 databases considered studies and opinion papers published between January 1999 and April 2010 in English. METHODOLOGICAL QUALITY All retrieved studies and opinion papers were assessed by two independent reviewers using the standardised Joanna Briggs Institute critical appraisal tools. DATA COLLECTION Data were extracted from included papers using the standardised Joanna Briggs Institute data extraction tool. DATA SYNTHESIS Data synthesis used the Joanna Briggs Institute approach for meta-synthesis by meta-aggregation. Findings were synthesised into categories and categories were aggregated into synthesised findings. RESULTS On the basis of critical appraisal, no opinion papers were included in the review. A total of 11 qualitative studies were included, yielding a total of 313 findings. These were synthesised into 64 categories which were further synthesised into 11 synthesised findings about factors that facilitate and inhibit the role's implementation and development. CONCLUSION Drawing directly on consultant nurses' experiences, these findings add evidence to what is already known about what does and does not work in developing a consultant role. They indicate that an understanding about the role's core functions is needed, as is a supportive environment in which the consultant can fully operate. IMPLICATIONS FOR PRACTICE The implications for practice are derived from the results of the synthesised findings. An organisation, through its policies, practices, procedures and individuals, must support the consultant's leadership and collaborative goal directed approach to care delivery and service development. This can be achieved by allowing the consultant both autonomy and authority. The synthesised findings reinforce the need to optimise the facilitators and minimise the inhibitors of role development. They can also make a contribution to the conceptual understanding of the consultant role. IMPLICATIONS FOR RESEARCH Further research into the experiences of consultant nurses is necessary - in particular, how nurse consultants interpret their relationships with others, negotiate resources and demonstrate
背景:如果新兴的“开拓者”,如咨询护士,要成功地发展和维持新的工作方式,那么支持或抑制新角色发展的因素需要确定。自从13年前在英国引入咨询护士的角色以来,关于咨询护士的经验的评估和轶事证据越来越多。目的综合英国会诊护士在实施新角色方面的经验,以识别角色发展的抑制因素和促进因素。纳入标准本综述寻求定性和混合方法研究,这些研究产生了关于感兴趣现象的定性数据,以及叙述性意见文件,即咨询护士角色发展的经验。检索策略:在14个数据库中检索了1999年1月至2010年4月期间以英文发表的研究和意见论文。方法学质量所有检索到的研究和观点论文均由两名独立审稿人使用标准化的乔安娜布里格斯研究所关键评估工具进行评估。数据收集使用标准化的Joanna Briggs研究所数据提取工具从纳入的论文中提取数据。数据综合数据综合使用了乔安娜布里格斯研究所的方法,通过元聚合进行元综合。结果被综合成类别,类别被汇总成综合结果。结果在批判性评价的基础上,未收录意见论文。共纳入了11项定性研究,共得出313项发现。这些被综合为64个类别,这些类别进一步被综合为11个关于促进和抑制角色实施和发展的因素的综合调查结果。结论直接借鉴会诊护士的经验,这些发现为已经知道的在发展会诊护士角色中什么起作用和不起作用提供了证据。它们表明,需要了解该角色的核心职能,以及顾问能够充分发挥作用的支持性环境。对实践的启示对实践的启示来自于综合研究结果的结果。一个组织,通过它的政策、实践、程序和个人,必须支持咨询师的领导和协作目标导向的方法来提供护理和服务发展。这可以通过允许顾问拥有自主权和权威来实现。综合研究结果强调了优化促进因素和最小化角色发展抑制因素的必要性。它们也有助于从概念上理解顾问的作用。对研究的启示对会诊护士的经验进行进一步的研究是必要的——特别是,会诊护士如何解释他们与他人的关系,谈判资源,并展示他们在每个核心职能中的作用,特别是领导职能的影响。
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引用次数: 0
Determinants of non‐compliance with Antiretroviral Therapy among adults living with HIV/AIDS: A Systematic Review 成人艾滋病毒/艾滋病感染者抗逆转录病毒治疗不依从性的决定因素:一项系统综述
Pub Date : 2012-01-01 DOI: 10.11124/01938924-201210560-00001
D. Gemeda, L. Gebretsadik, T. Dejene, Mirkuzie Wolde, M. Sudhakar
Background Non‐compliance with Antiretroviral Therapy is a major public health concern and further challenged by interaction of various social and clinical obstacles. So; near perfect pill taking is desirable in order to maximise its benefits. Objectives To systematically search, appraise and synthesise the best available evidence on determinants of non‐compliance with Antiretroviral Therapy among adults living with HIV/AIDS and provide direction to future how to increase compliance with Antiretroviral Therapy. Inclusion criteria Types of participants The systematic review considered studies with 18 years and above year old adults living with HIV/AIDS. Focus of the review Determinants of non‐compliance with Antiretroviral Therapy among adults living with HIV/AIDS. Types of studies Quantitative study designs were considered for inclusion. Types of outcomes Socio‐economic, Health service, Psychosocial and behavioural and Clinical related outcomes. Search strategy English language articles published between January1997 and December 2011 were sought across major databases. Methodological quality Methodological quality was assessed using Joanna Briggs Institute Meta Analysis of Statistical Assessment and Review Instrument critical appraisal tools. Data collection Data were extracted from papers included in the review by using a standardized data extraction tool. Data synthesis Meta‐ analysis was conducted using fixed and random effects model with mantel Haenszel method using Revman5 software. Heterogeneity between the studies was assessed using &khgr;2 test at a p‐value of <0.05. Summary statistics were expressed as adjusted odds ratio or adjusted risk ratio with 95% confidence intervals at a p‐value of <0.05. Results Nine studies (seven cross‐sectional, one cohort study and one case‐control study) were included in the review. Results from meta analysis showed that white race adults living with HIV/AIDS were 1.38 times more likely to non‐comply with Antiretroviral Therapy when compared with black adults living with HIV/ AIDS (Adjusted Relative Risk=1.38; 95%CI=1.21, 1.58, p value<0.00001). Non‐depressed adults living with HIV/AIDS were 1.77 times more likely to non‐comply with Antiretroviral Therapy when compared with depressed adults living with HIV/AIDS (Adjusted Odds ratio =1.77; 95%CI=1.17, 2.69, p value=0.007). Substance non‐user adults living with HIV/ AIDS were 2.04 times more likely to non‐comply with Antiretroviral Therapy when compared with substance user adults living with HIV/ AIDS (Adjusted Relative Risk =2.04; 95%CI=1.51, 2.74, p value=<0.00001). Adults living with HIV/ AIDS with baseline CD4 count ≥200cells/ml were 1.8 times more likely to non‐comply with Antiretroviral Therapy when compared with adults livings with HIV/ AIDS with baseline CD4 count ≥200cells/ml (Adjusted Odds ratio=1.84; 95%CI=1.08, 3.15, p value=0.03). Conclusion We found the base line CD4 count ≥200cells/ml, not being depressed; not using substances and being white i
背景:抗逆转录病毒治疗的不依从性是一个主要的公共卫生问题,并受到各种社会和临床障碍的进一步挑战。所以;近乎完美的服药方式是可取的,以使其益处最大化。目的系统地搜索、评估和综合成人艾滋病毒/艾滋病感染者抗逆转录病毒治疗不依从性决定因素的最佳现有证据,并为未来如何提高抗逆转录病毒治疗的依从性提供指导。纳入标准参与者类型系统评价考虑的是18岁及以上成年HIV/AIDS感染者。成人艾滋病毒/艾滋病感染者抗逆转录病毒治疗不依从性的决定因素研究类型纳入考虑定量研究设计。结果类型:社会经济、卫生服务、社会心理和行为以及临床相关结果。1997年1月至2011年12月期间发表的英语文章在主要数据库中进行搜索。方法质量采用乔安娜布里格斯研究所统计评估Meta分析和回顾工具关键评估工具进行评估。使用标准化数据提取工具从纳入综述的论文中提取数据。采用固定效应和随机效应模型,采用mantel - Haenszel法,采用Revman5软件进行Meta分析。研究间的异质性采用&khgr;2检验,p值<0.05。汇总统计量以校正优势比或校正风险比表示,95%置信区间p值<0.05。结果共纳入9项研究(7项横断面研究,1项队列研究和1项病例对照研究)。荟萃分析结果显示,白人成年HIV/AIDS感染者不遵守抗逆转录病毒治疗的可能性是黑人成年HIV/AIDS感染者的1.38倍(调整后相对风险=1.38;95%CI=1.21, 1.58, p值<0.00001)。与患有抑郁症的艾滋病毒/艾滋病的成年人相比,非抑郁的艾滋病毒/艾滋病成年人不遵守抗逆转录病毒治疗的可能性高1.77倍(校正优势比=1.77;95%CI=1.17, 2.69, p值=0.007)。与患有艾滋病毒/艾滋病的成人药物使用者相比,患有艾滋病毒/艾滋病的成人药物使用者不遵守抗逆转录病毒治疗的可能性高2.04倍(调整相对风险=2.04;95%CI=1.51, 2.74, p值<0.00001)。与基线CD4计数≥200cells/ml的成人HIV/ AIDS感染者相比,基线CD4计数≥200cells/ml的成人HIV/ AIDS感染者不遵守抗逆转录病毒治疗的可能性高1.8倍(校正优势比=1.84;95%CI=1.08, 3.15, p值=0.03)。结论基线CD4计数≥200cells/ml,未出现下降;不使用药物和白人与抗逆转录病毒治疗不依从性相关。对实践的影响应鼓励通过咨询来改变行为,以提高依从性。提醒他们定期、及时地服用药物,鼓励他们坚持下去,帮助他们遵守门诊预约,并为感染艾滋病毒/艾滋病的成年人提供情感支持,这些都很重要。进一步的研究使用更可靠的实验方法将有助于进一步探索本综述的发现。
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引用次数: 12
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JBI library of systematic reviews
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