SpiceRDb:“香料疾病”疗法的综合知识库

Q2 Medicine In Silico Biology Pub Date : 2010-02-15 DOI:10.1145/1722024.1722057

R. Pauly, M. Pradhan, M. Palakal

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引用次数: 0

摘要

SpiceRDb知识库是一个独特的尝试，阐明香料对各种疾病途径的作用背后的科学，使用文本挖掘和分子建模工具。这些香料疗法已被证明对从多发性硬化症到结直肠癌的广泛疾病有治疗作用。此外，对接研究发现姜黄的一种成分姜黄素是结直肠肿瘤的潜在疾病生物标志物。因此，SpiceRDb知识库的有用性促使我们将其提供给公众社区，以便从有关替代医学项目的大量可用知识和支持香料疗法益处的最新科学证据中受益。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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SpiceRDb: an integrated knowledgebase of "spice-disease" remedies

SpiceRDb knowledgebase is a unique attempt to elucidate the science behind the action of spices on various disease pathways, using text mining and molecular modeling tools. These spice-remedies have been demonstrated to mediate therapeutic benefits for wide spectra of diseases ranging from multiple sclerosis to colorectal cancer. Furthermore, the docking studies identified curcumin, a component of turmeric, to be a potential disease biomarker for colorectal neoplasm. Thus, the usefulness of the SpiceRDb knowledgebase motivates us to make it available to the public community in order to benefit from the vast knowledge available about alternative medicine projects and the recent scientific evidences supporting the benefits of spice-remedies.

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来源期刊

In Silico Biology Computer Science-Computational Theory and Mathematics

CiteScore

2.20

自引率

0.00%

发文量

期刊介绍： The considerable "algorithmic complexity" of biological systems requires a huge amount of detailed information for their complete description. Although far from being complete, the overwhelming quantity of small pieces of information gathered for all kind of biological systems at the molecular and cellular level requires computational tools to be adequately stored and interpreted. Interpretation of data means to abstract them as much as allowed to provide a systematic, an integrative view of biology. Most of the presently available scientific journals focus either on accumulating more data from elaborate experimental approaches, or on presenting new algorithms for the interpretation of these data. Both approaches are meritorious.