儿童中枢神经系统肿瘤抗肿瘤治疗后营养状况及影响因素的回顾性分析

A. Vashura, I. Borodina, A. Khavkin, Y. Alymova, T. Kovtun, S. Lukina
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引用次数: 0

摘要

目标。目的研究接受抗肿瘤治疗的中枢神经系统(CNS)肿瘤患儿营养状况(NS)紊乱的患病率及影响这些过程的可能因素。患者和方法。回顾性分析109例8 ~ 17岁患者(42.2%为男孩)的资料,其中57.8%为中枢神经系统恶性肿瘤(MT), 42.2%为良性肿瘤(BT)。治疗后1 ~ 58个月。检查体重指数(BMI)、脂肪质量指数(FMI)、无脂质量指数(FFMI)、膳食成分、内分泌紊乱(生长激素(GH)缺乏和甲状腺功能减退)。结果。54.1%的儿童BMI在参考范围内,29.4%的儿童身体成分正常。27.5%的儿童缺乏生长激素,43.1%的儿童体脂过多。MT患儿的BMI (p = 0.009)和FFMI (p = 0.011)低于BT患儿,治疗后2 ~ 5年的患儿BMI高于BT患儿(p = 0.041)。MT患者更容易出现GH缺乏症(p = 0.016), MT和BT儿童甲状腺功能低下的频率没有差异。发现乳制品、发酵乳制品、乳制品和肉类组合菜肴的摄入频率与FFMI值呈正相关,面食与肉类或香肠制品和FMI值呈正相关,FFMI与糖制品摄入呈负相关。结论。在患有中枢神经系统肿瘤的儿童中,营养失调在抗肿瘤治疗后很常见,而且随着时间的推移,营养失调并不会得到改善。仅测量BMI并不足以评估营养状况。很大一部分患者的饮食失调在实践中为饮食矫正提供了依据。关键词:儿童,脑肿瘤,长期预后,营养状况,身体成分,营养
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Nutritional status and factors affecting it in children with central nervous system tumors after anti-tumor therapy: a retrospective analysis
Objective. To study the prevalence of nutritional status (NS) disorders and possible factors affecting these processes in children with central nervous system (CNS) tumors who underwent anti-tumor therapy. Patients and methods. A retrospective analysis of data from 109 patients aged 8 to 17 years (42.2% of boys) was performed, of whom 57.8% had malignant tumors (MT) of the CNS and 42.2% had benign tumors (BT). The post-treatment period was 1 to 58 months. The body mass index (BMI), fat mass index (FMI), fat-free mass index (FFMI), dietary composition, and endocrine disorders (growth hormone (GH) deficiency and hypothyroidism) were examined. Results. BMI was within the reference range in 54.1% of children, normal body composition was revealed in 29.4%. GH deficiency was found in 27.5% of children, and excess body fat in 43.1%. BMI (p = 0.009) and FFMI (p = 0.011) were lower in children with MT than in children with BT. In children with the post-treatment period of 2 to 5 years, BMI was higher (p = 0.041). Patients with MT were more likely to have GH deficiency (p = 0.016), the frequency of hypothyroidism did not differ in children with MT and BT. A direct association was found between the frequency of intake of dairy, fermented dairy, combination of dairy and meat dishes and the value of FFMI, pasta combined with meat or sausage products and FMI, and an inverse association between FFMI and intake of sugar products. Conclusions. In children with CNS tumors, nutritional disorders are common after anti-tumor therapy that do not tend to improve over time. Measuring BMI alone is not sufficient to assess nutritional status. Dietary disturbances in a significant proportion of patients provide grounds for dietary correction in practice. Key words: children, brain tumors, long-term outcomes, nutritional status, body composition, nutrition
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来源期刊
Voprosy Detskoi Dietologii
Voprosy Detskoi Dietologii Medicine-Pediatrics, Perinatology and Child Health
CiteScore
1.20
自引率
0.00%
发文量
17
期刊介绍: The scientific journal Voprosy Detskoi Dietologii is included in the Scopus database. Publisher country is RU. The main subject areas of published articles are Food Science, Pediatrics, Perinatology, and Child Health, Nutrition and Dietetics, Клиническая медицина.
期刊最新文献
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