一组microRNA基因的甲基化:肾细胞癌转移的标志物

IF 0.1 Q4 ONCOLOGY Onkourologiya Pub Date : 2021-02-10 DOI:10.17650/1726-9776-2020-16-4-32-38

N. Apanovich, V. I. Loginov, E. Filippova, D. S. Khodyrev, A. Burdennyy, I. Pronina, N. Ivanova, S. Lukina, T. Kazubskaya, V. Matveev, A. Karpukhin, E. Braga

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引用次数: 1

摘要

这4个基因用于潜在转移预后系统，临床敏感性为68%，特异性为84%(曲线下面积0.83)，将应用于RCC患者个性化治疗系统的最终开发。结论。MIR1258的甲基化与RCC转移的关联首次被发现，并且作为一种新的有希望的转移复发预后标记物具有独立的兴趣。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Methylation of a group of microRNA genes: markers of renal cell carcinoma metastasis

methylation late (III–IV) of metastasis lymph nodes These 4 genes used to a potential metastatic prognosis system with a clinical sensitivity of 68 % and a specificity of 84 % (area under curve 0.83), which will be applied in the final development of a system for personalized therapy of RCC patients. Conclusion. The association of methylation of the MIR1258 with RCC metastasis has been shown for the first time and is of independent inter-est as a new promising marker for the prognosis of metastatic relapses.

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来源期刊

Onkourologiya ONCOLOGY-

CiteScore

0.40

自引率

0.00%

发文量

审稿时长

10 weeks

期刊介绍： The main objective of the journal "Cancer urology" is publishing up-to-date information about scientific clinical researches, diagnostics, treatment of oncologic urological diseases. The aim of the edition is to inform the experts on oncologic urology about achievements in this area, to build understanding of the necessary integrated interdisciplinary approach in therapy, alongside with urologists, combining efforts of doctors of various specialties (cardiologists, pediatricians, chemotherapeutists et al.), to contribute to raising the effectiveness of oncologic patients’ treatment.