基于MRI和SPECT数据的患者特异性1D-0D模拟的发展

Q4 Engineering Journal of Biorheology Pub Date : 2018-01-01 DOI:10.17106/JBR.32.2
Hao Zhang, N. Fujiwara, Masaharuo Kobayashi, S. Yamada, F. Liang, S. Takagi, M. Oshima
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引用次数: 5

摘要

威利斯循环(CoW)血流动力学被认为是了解脑循环疾病进展的重要因素。本研究提出了一种将1D-0D模型与磁共振成像(MRI)和单光子发射计算机断层扫描(SPECT)医学成像数据相结合的方法来研究奶牛的血流动力学。MRI数据作为1D模型的动脉几何参数。以SPECT数据作为奶牛输出动脉血流速率的参考数据,提示是否需要对0D模型的外周脑阻力进行调整。我们将该方法应用于两例患者,并将模拟结果与PC-MRI测量数据进行了比较。对比结果表明,两种情况下,模拟结果与实测数据的传入动脉血流分布差异分别为0.6 ~ 6.0%和5.7 ~ 13.2%。两种模拟都捕捉到了牛体内流动分布的个体差异。结果表明,我们的方法可用于获得个体患者的血液动力学信息。
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Development of patient-specific 1D-0D simulation based on MRI and SPECT data
The hemodynamics of blood flow in the Circle of Willis (CoW) is considered to be important for the understanding of disease progression in cerebral circulation. In this research, we developed a method by combining 1D-0D model with the medical imaging data of magnetic resonance imaging (MRI) and single photon emission computed tomography (SPECT), in order to investigate the hemodynamics in CoW. The MRI data was used as the arterial geometry parameter for 1D model. The SPECT data was used as the reference data for the flow rates at the efferent arteries of CoW, which indicated if adjustment needed to be made to the peripheral cerebral resistance for 0D model. We applied our method to two patients and compared the simulation results with PC-MRI measurement data. The comparison showed the differences of flow distribution in the afferent arteries between simulation results and measurement data were 0.6–6.0% and 5.7–13.2% respectively in two cases. Both simulations captured the individual difference of flow distribution in the CoW. The results suggested that our method can be used to obtain the hemodynamics information in the CoW for an individual patient.
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来源期刊
Journal of Biorheology
Journal of Biorheology Engineering-Mechanical Engineering
CiteScore
0.50
自引率
0.00%
发文量
5
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