COLLAGEN TYPE IV IN THE DETECTION OF THE EROSIVE ESOPHAGEAL DAMAGE IN PATIENTS WITH GASTROESOPHAGEAL REFLUX DISEASE

Background. Searching for biomarkers of erosive esophageal damage in patients with gastroesophageal reflux disease (GERD) seems to have scientific and clinical significance. The objective of the study was to evaluate plasma collagen type IV levels in patients with GERD according to the nature of esophageal mucosa damage. Materials and methods. 90 patients have been examined: 64 with GERD, 26 of the control group. Esophagogastroduodenoscopy with biopsy of the lower third of the esophagus was performed. The collagen type IV level was evaluated in 51 patients using enzyme-linked immunosorbent assay. To determine the threshold level of collagen type IV indicating the presence of erosive esophageal damage in patient with GERD mathematical model has been created. Results. Patients with erosive esophageal damage have higher plasma levels of collagen type IV concentration than patients with nonerosive GERD and those of the control group. According to the logistic model and ROC analysis patients with plasma collagen type IV level equal or more than 6,08 ng/ml have a high risk of erosive esophageal damage, accuracy 91,89%, sensitivity 90,91%, specificity 92,31%. Conclusion. Collagen type IV level can be regarded as a biomarker of erosive esophageal damage in patients with GERD. Plasma collagen type IV level equal or more than 6,08 ng/ml indicates the presence of erosive esophageal damage in patient with GERD.