门静脉系统分流犬血浆蛋白C活性的评估

IF 0.6 4区 农林科学 Q3 VETERINARY SCIENCES Acta Veterinaria Brno Pub Date : 2023-01-01 DOI:10.2754/avb202392030289
A. Nečasová, J. Lorenzova, K. Řeháková, Danka Haruštiaková, A. Nečas
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引用次数: 0

摘要

门静脉系统分流(PSS)是一种血管疾病,可通过多种外科技术治疗。目前的兽医研究正在评估PSS犬的新的预后标志物。本研究旨在评估34只PSS患者(n = 34)血浆蛋白C活性的预后价值。分别于术前(T1)、术后2天(T2)、术后8周(T3)、术后6个月(T4)测定血浆蛋白C活性。血浆蛋白C活性在T1/T2和T3/T4之间显著升高(P < 0.001)。血浆蛋白C活性与性别(P = 0.676)、年龄(P = 0.172)、品种(P = 0.573)、临床症状类型(神经学P = 0.993;胃肠道P = 0.924;尿路P = 0.385)和门系统分流类型(P = 0.516),但下腔型肝外PSS终止犬的血浆蛋白C活性值显著低于膈型肝外PSS终止犬(P = 0.031)。血浆蛋白C活性与狗的死亡概率(P = 0.334)和狗的临床结局(P = 0.960)无显著关系。虽然不是预后因素,但蛋白C活性是一种实验室标记物,可用于犬PSS的诊断,也可用于术后监测。
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Assessment of plasma protein C activity in dogs with portosystemic shunt
Portosystemic shunt (PSS) is a vascular disease that can be treated by various surgical techniques. Current veterinary studies are evaluating new prognostic markers in dogs with PSS. This study aims at evaluating the prognostic value of plasma protein C activity in dogs (n = 34) with PSS treated surgically using an ameroid constrictor. Plasma protein C activity was measured in the following time periods: preoperatively (T1), 2 days after surgery (T2), 8 weeks after surgery (T3) and > 6 months after surgery (T4). There was a significant increase in plasma protein C activity between T1/T2 and T3/T4 (P < 0.001). There was no significant relationship between the plasma protein C activity and sex (P = 0.676), age (P = 0.172), breed (P = 0.573), type of clinical signs (neurological P = 0.993; gastrointestinal P = 0.924; urological P = 0.385) and type of portosystemic shunt (P = 0.516), except for dogs with a caval type of extrahepatic PSS termination that had significant lower plasma protein C activity values compared to dogs with a diaphragmatic type of extrahepatic PSS (P = 0.031). No significant relationship was found between plasma protein C activity and the probability of the dog’s death (P = 0.334) or the dog’s clinical outcome (P = 0.960). Although not a prognostic factor, protein C activity is a laboratory marker that is useful for the diagnosis of PSS in dogs and can also be helpful in the postoperative monitoring.
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来源期刊
Acta Veterinaria Brno
Acta Veterinaria Brno 农林科学-兽医学
CiteScore
1.00
自引率
33.30%
发文量
36
审稿时长
18-36 weeks
期刊介绍: ACTA VETERINARIA BRNO is a scientific journal of the University of Veterinary and Pharmaceutical Sciences in Brno, Czech Republic. The scientific journal Acta Veterinaria Brno is dedicated to the publication of original research findings and clinical observations in veterinary and biomedical sciences. Original scientific research articles reporting new and substantial contribution to veterinary science and original methods that have not been submitted for publication elsewhere are considered for publication. A written statement to this effect should accompany the manuscript, along with approval for publication by the author´s head of department. The authors bear full responsibility for the contents of their contribution. Book reviews are published, too.
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