P. B. B. Fonseca, C. Farhat, R. Succi, A. Machado, J. Braga
{"title":"7价肺炎球菌结合疫苗免疫儿童镰状细胞病鼻咽肺炎链球菌对青霉素的耐药性","authors":"P. B. B. Fonseca, C. Farhat, R. Succi, A. Machado, J. Braga","doi":"10.4236/WJV.2013.32005","DOIUrl":null,"url":null,"abstract":"To assess the prevalence, \nthe antimicrobials resistance and to identify risk factors of nasopharyngeal \ncolonization by Streptococcus pneumoniae in \nchildren with sickle cell disease (SCD) using prophylactic penicillin and \nimmunized with 7-valent pneumococcal conjugate vaccine. A total of 424 swabs \nwere collected from the nasopharynx in 216 children with SCD and 109 samples \nfrom the control group, both from 2 to 60 months age range. Isolation and \nidentification of pneumococci followed standard procedures. Minimum inhibitory \nconcentration (MIC) for penicillin was determined by the E-test method. \nPrevalence of nasopharyngeal colonization by pneumococci in children with SCD \nwas 17%, and 11% in the control group. The risk factors for increased \ncolonization in children with SCD were the presence of more than five people at \nhome, daycare/school attendance and low prophylaxis compliance. The prevalence \nof strains with penicillin resistance was 57.5% in patients with SCD and 25% in \nthe control group. Conclusions: Prevalence \nof pneumococci nasopharyngeal colonization was similar among the study groups. \nProphylactic use of penicillin may have increased the prevalence of resistant \nstrains. The vaccine did not decrease the colonization with penicillin \nresistant strains.","PeriodicalId":57190,"journal":{"name":"疫苗(英文)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2013-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":"{\"title\":\"Penicillin Resistance in Nasopharyngeal Streptococcus pneumoniae among Children with Sickle Cell Disease Immunized with 7-Valent Pneumococcal Conjugate Vaccine\",\"authors\":\"P. B. B. Fonseca, C. Farhat, R. Succi, A. Machado, J. Braga\",\"doi\":\"10.4236/WJV.2013.32005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"To assess the prevalence, \\nthe antimicrobials resistance and to identify risk factors of nasopharyngeal \\ncolonization by Streptococcus pneumoniae in \\nchildren with sickle cell disease (SCD) using prophylactic penicillin and \\nimmunized with 7-valent pneumococcal conjugate vaccine. A total of 424 swabs \\nwere collected from the nasopharynx in 216 children with SCD and 109 samples \\nfrom the control group, both from 2 to 60 months age range. Isolation and \\nidentification of pneumococci followed standard procedures. Minimum inhibitory \\nconcentration (MIC) for penicillin was determined by the E-test method. \\nPrevalence of nasopharyngeal colonization by pneumococci in children with SCD \\nwas 17%, and 11% in the control group. The risk factors for increased \\ncolonization in children with SCD were the presence of more than five people at \\nhome, daycare/school attendance and low prophylaxis compliance. The prevalence \\nof strains with penicillin resistance was 57.5% in patients with SCD and 25% in \\nthe control group. Conclusions: Prevalence \\nof pneumococci nasopharyngeal colonization was similar among the study groups. \\nProphylactic use of penicillin may have increased the prevalence of resistant \\nstrains. The vaccine did not decrease the colonization with penicillin \\nresistant strains.\",\"PeriodicalId\":57190,\"journal\":{\"name\":\"疫苗(英文)\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-05-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"疫苗(英文)\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.4236/WJV.2013.32005\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"疫苗(英文)","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4236/WJV.2013.32005","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Penicillin Resistance in Nasopharyngeal Streptococcus pneumoniae among Children with Sickle Cell Disease Immunized with 7-Valent Pneumococcal Conjugate Vaccine
To assess the prevalence,
the antimicrobials resistance and to identify risk factors of nasopharyngeal
colonization by Streptococcus pneumoniae in
children with sickle cell disease (SCD) using prophylactic penicillin and
immunized with 7-valent pneumococcal conjugate vaccine. A total of 424 swabs
were collected from the nasopharynx in 216 children with SCD and 109 samples
from the control group, both from 2 to 60 months age range. Isolation and
identification of pneumococci followed standard procedures. Minimum inhibitory
concentration (MIC) for penicillin was determined by the E-test method.
Prevalence of nasopharyngeal colonization by pneumococci in children with SCD
was 17%, and 11% in the control group. The risk factors for increased
colonization in children with SCD were the presence of more than five people at
home, daycare/school attendance and low prophylaxis compliance. The prevalence
of strains with penicillin resistance was 57.5% in patients with SCD and 25% in
the control group. Conclusions: Prevalence
of pneumococci nasopharyngeal colonization was similar among the study groups.
Prophylactic use of penicillin may have increased the prevalence of resistant
strains. The vaccine did not decrease the colonization with penicillin
resistant strains.