Ayat Yousse, A. Baiomy, S. Fahmy, A. Mohamed, D. Saad, Reham Desoky
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Potential anti-osteoporotic effect of Allolobophora caliginosa extract in orchiectomized rats
Osteoporosis is defined as a universal skeletal disorder. The medicinal importance of earthworms has been known from time immemorial. The present investigation was designed to assess the antiosteoporotic efficacy of the earthworm, Allolobophora caliginosa extract (AcE) in bilaterally orchiectomized rats (OCX) to elicit the underlying in vivo mechanism. Twenty-eight male rats were divided into two groups. The first group (7 rats/group) represented sham-operated rats, while the second group (21 rats/group) underwent bilateral orchidectomy (OCX). The second group was randomly subdivided into three subgroups; OCX and A. caliginosa extract (AcE) (100 or 200 mg/kg body weight/day) treated subgroup. Administration of AcE to OCX rats increased femoral bone mineral density (BMD), bone mineral content (BMC), calcium (Ca), phosphorus (P), and calcitonin level, as compared to OCX rats. On the other hand, administration of AcE to OCX rats significantly decreased serum alkaline phosphatase (ALP) activity and parathyroid hormone (PTH) level compared to OCX rats. The present study showed that AcE is a beneficial novel natural antiresorptive agent. Its anti-osteoporotic effects may positively impact osteoblast differentiation, particularly bone mineralization, and higher osteoblast activity account for bone formation, preventing osteoporosis.
Pharmaceutical Sciences AsiaPharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
0.90
自引率
0.00%
发文量
59
期刊介绍：
The Pharmaceutical Sciences Asia (PSA) journal is a double-blinded peer-reviewed journal in English published quarterly, by the Faculty of Pharmacy, Mahidol University, Thailand. The PSA journal is formerly known as Mahidol University Journal of Pharmaceutical Sciences and committed to the timely publication of innovative articles and reviews. This journal is available in both printed and electronic formats. The PSA journal aims at establishing a publishing house that is open to all. It aims to disseminate knowledge; provide a learned reference in the field; and establish channels of communication between academic and research expert, policy makers and executives in industry and investment institutions. The journal publishes research articles, review articles, and scientific commentaries on all aspects of the pharmaceutical sciences and multidisciplinary field in health professions and medicine. More specifically, the journal publishes research on all areas of pharmaceutical sciences and related disciplines: Clinical Pharmacy Drug Synthesis and Discovery Targeted-Drug Delivery Pharmaceutics Biopharmaceutical Sciences Phytopharmaceutical Sciences Pharmacology and Toxicology Pharmaceutical Chemistry Nutraceuticals and Functional Foods Natural Products Social, Economic, and Administrative Pharmacy Clinical Drug Evaluation and Drug Policy Making Antimicrobials, Resistance and Infection Control Pharmacokinetics and Pharmacodynamics.
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