构建细胞微环境以控制毛细血管内皮细胞增殖、死亡和分化

C. Nelson
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引用次数: 0

摘要

细胞表面受体与局部生物活性配体之间的动态结合相互作用是细胞调查其微环境并相应地调节其行为(如增殖、分化、迁移和自杀)的主要机制。使用传统和非传统的微加工方法来设计定义良好的细胞微环境,我们正在研究细胞如何识别和响应与不溶性细胞外基质(ECM)的粘附相互作用。我们将讨论我们控制粘合剂相互作用的结构和几何的方法,以及我们在识别和阐明细胞感知ECM内携带的物理、化学和结构信息的机制方面取得的进展。通过发展这些工程细胞表面相互作用的方法,我们希望改善人工表面和活细胞之间的相互联系。
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Building Cellular Microenvironments to Control Capillary Endothelial Cell Proliferation, Death, and Differentiation
The dynamic binding interactions between cell surface receptors and local bioactive ligands serves as the principal mechanism by which cells survey their microenvironment and accordingly modulate their behaviors, such as proliferation, differentiation, migration, and suicide. Using conventional and non-conventional microfabrication approaches to engineer well-defined cellular microenvironments, we are examining how cells recognize and respond to adhesive interactions with the insoluble extracellular matrix (ECM). We will discuss our approaches to control the architecture and geometry of the adhesive interactions, as well as our resulting progress in identifying and elucidating the mechanisms by which cells sense the physical, chemical, and structural information carried within the ECM. By developing these approaches to engineering cell-surface interactions, we hope to improve the interconnect between artificial surfaces and living cells.
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