{"title":"本期重点报道","authors":"I. Wacogne","doi":"10.1136/archdischild-2018-316456","DOIUrl":null,"url":null,"abstract":"Is NICE ageist? In the UK, new health technologies are assessed by the National Institute for Clinical Excellence (NICE). NICE determines the cost incurred for each additional quality-adjusted life-year (QALY) that the new technology provides over and above the currently standard treatment. Though there is considerable flexibility in the process, technologies which offer a costper-QALYof £20 000-£30 000 or less would normally be recommended for use. The thought is that, given a fixed total health budget, use of technologies with a higher cost-per-QALY will generally decrease aggregate health by displacing more cost-effective interventions. One criticism levelled at NICE maintains that its methodology is ageist. Since younger people typically have a longer life expectancy than older people, a life-saving treatment will tend to produce more QALYs in a younger person. 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引用次数: 0

摘要

NICE是年龄歧视吗?在英国,新的卫生技术由国家临床卓越研究所(NICE)进行评估。NICE确定了新技术在当前标准治疗之上提供的每一个额外的质量调整寿命年(QALY)所产生的成本。虽然在这个过程中有相当大的灵活性,但通常建议使用成本为2万至3万英镑或更低的技术。其想法是,在卫生总预算固定的情况下,使用每质量质量aly成本较高的技术通常会取代成本效益更高的干预措施,从而降低总体卫生水平。一种针对NICE的批评认为它的方法是年龄歧视。由于年轻人的预期寿命通常比老年人更长,因此挽救生命的治疗往往会在年轻人身上产生更多的QALYs。改善生活质量的干预也是如此,因为它将在更长的时间内改善生活质量。NICE的方法可以说是系统地偏向于年轻人。在本期中,史蒂文斯及其合作者(见第258页)回应了这一指控。他们承认,按质量计算费用的方法可能不利于老年人,但他们认为,这种方法只会在从未发生过的罕见病例中起作用。这些很可能是极其昂贵的干预措施,可以治愈迫在眉睫的致命疾病并恢复正常的预期寿命。此外,即使这样的情况确实发生了,NICE也可能会推荐使用这种干预措施。Stevens和合作者注意到NICE的专家咨询委员会有相当大的余地来考虑每个质量质量成本之外的因素。他们还指出了NICE程序的各种其他特征,这些特征倾向于防止年龄歧视的决定。在一篇评论中(见第263页),John Harris和Sadie Regmi对NICE的辩护做出了回应,他们认为NICE的方法在理论上是年龄歧视,即使在实践中没有。他们声称,它表达了这样一种观点,即老年人“不值得花费资源”,并且使用了“武断”的考虑因素,比如一个人的基线预期寿命和生活质量,来为决策提供信息。哈里斯和雷米指出,资源分配过程“理论上”可能存在年龄歧视,这一点当然是正确的。但史蒂文斯及其合作者提出的观点可能仍具有重要意义,因为在实践中,年龄歧视可能也很重要。Harris和Regmi将年龄歧视和种族主义进行了类比,并认为NICE更像是一个种族主义者,尽管有种族主义信仰,但从不以种族主义的方式行事。但可以肯定的是,这个种族主义者比一个在思想和行动上都是彻头彻尾的种族主义者要好一些。即使NICE的方法存在年龄歧视,但事实上,这种年龄歧视很少会出现在NICE的决策中,这可能会缓解这个问题。此外,正如哈里斯和雷格米所承认的那样,人们可能会质疑NICE的方法在理论上是否真的是年龄歧视。基线生活质量和预期寿命与确定个体将从治疗中获得的获益量有关,当然可以质疑干预产生的获益量是否是“武断”的考虑。
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Highlights from this issue
Is NICE ageist? In the UK, new health technologies are assessed by the National Institute for Clinical Excellence (NICE). NICE determines the cost incurred for each additional quality-adjusted life-year (QALY) that the new technology provides over and above the currently standard treatment. Though there is considerable flexibility in the process, technologies which offer a costper-QALYof £20 000-£30 000 or less would normally be recommended for use. The thought is that, given a fixed total health budget, use of technologies with a higher cost-per-QALY will generally decrease aggregate health by displacing more cost-effective interventions. One criticism levelled at NICE maintains that its methodology is ageist. Since younger people typically have a longer life expectancy than older people, a life-saving treatment will tend to produce more QALYs in a younger person. So too will a quality-of-life-improving intervention, since it will improve quality of life over a longer period. The NICE approach might be said to systematically favour younger people. In this issue, Stevens and collaborators (see page 258) respond to this charge. They concede that the cost-per-QALY approach could disfavour the elderly, but argue that it will do so only in rare casesd cases that have never occurred. These would most likely be cases of extremely expensive interventions that cure imminently fatal conditions and restore normal life-expectancy. Moreover, even if such a case did occur, NICE might nevertheless recommend the intervention for use. Stevens and collaborators note that NICE’s expert advisory committees have considerable leeway to consider factors besides cost-per-QALY. They also point to various other features of the NICE process that tend to protect against ageist decisions. In a commentary (see page 263), John Harris and Sadie Regmi respond to this defence of NICE by arguing that the NICE approach is ageist in theory even if not in practice. They claim that it expresses the view that old people ‘are not worth the expenditure of resources’ and uses ‘arbitrary ’ considerations, such as one’s baseline life expectancy and quality of life, to inform decisions. Harris and Regmi are surely right to note that a resource allocation process could be ageist ‘in theory ’. But the points made by Stevens and collaborators might yet have significance, for ageism in practice may matter too. Harris and Regmi draw an analogy between ageism and racism, and suggest that NICE is rather like a racist person who, despite having racist beliefs, never acts in a racist way. But surely this racist is a less bad sort of racist than one who is thoroughly racist both in thought and action. Even if NICE’s methodology is ageist, the fact that this ageism rarely if ever finds its way into NICE decisions may mitigate the problem. Moreover, as Harris and Regmi acknowledge, one might dispute whether NICE’s methodology really is ageist even in theory. Baseline quality of life and life expectancy are arguably relevant to determining the amount of benefit that an individual will derive from a treatment, and it could certainly be questioned whether the amount of benefit produced by an intervention is an ‘arbitrary ’ consideration.
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