Mortality and Severity of COVID-19 Patients with Chronic Obstructive Pulmonary Disease: A Meta-Analysis

Background: COVID-19 has become a pandemic in all countries including Indonesia. The death rate from COVID-19 is concentrated in elderly patients and those with comorbidities. COPD is one of the comorbidities that can worsen and even cause death. COPD ranks in the top 3 leading causes of death in the world causing 2.3 million deaths in 2019. This study aims to analyze the effect of COPD comorbidities on mortality and severity of COVID-19 patients. Subjects and Method: This study used a systematic review and meta-analysis by following the PRISMA flow chart. Search articles through journal databases, namely: Google scholar, PubMed, Science Direct and Link Springer. The articles search was done by considering the eligibility criteria defined in the PICO model. P= COVID-19 patient;I= COPD participant;C= without COPD;O= need for mechanical ventilation, ICU admission, and death. Inclusion criteria were cohort full paper articles, in English, multivariate analysis with adjusted Odds Ratio. Articles analyzed with RevMan 5.3.