Correlation between changes in peak morning blood pressure and occurrence of cardiovascular and cerebrovascular events in patients with hypertension complicated by coronary heart disease

Objective To analyze the correlation between changes in peak morning blood pressure and occurrence of cardiovascular and cerebrovascular events in patients with hypertension complicated by coronary heart disease (CHD). Methods Ninety patients with hypertension complicanted by CHD who were admitted to Zhumadian Central Hospital from March 2015 to March 2018 were selected as research objects. The 24 h blood pressure was detected and recorded by dynamic blood pressure monitor. Patients with peak morning blood pressure greater than or equal to 35 mmHg (1 mmHg=0.133 kPa) were included in morning peak group (n=40), and patients with peak morning blood pressure lower than 35 mmHg were included in non-morning peak group (n=50). The general data, blood pressure parameters, incidences of cardiovascular and cerebrovascular events were compared between the two groups. All patients were followed up for one year. And the correlation between changes in peak morning blood pressure and occurrence of cardiovascular and cerebrovascular events was analyzed. Results The peak morning value, mean morning arterial pressure (MAP) and 24 h systolic blood pressure in morning peak group were higher than those in non-morning peak group (all P 0.05). During one-year follow-up, the morbidity rates of acute coronary syndrome, arrhythmia, ischemic cerebrovascular disease and hemorrhagic cerebrovascular disease in morning peak group were 25.00% (10/40), 22.50% (9/40), 20.00% (8/40) and 20.00% (8/40), respectively, higher than the 8.00%(4/50), 6.00%(3/50), 4.00%(2/50)amd 4.00%(2/50) in non-morning peak group (P 0.05). Conclusions The peak morning blood pressure in patients with hypertension complicated by CHD is closely related to occurrence of cardiovascular and cerebrovascular events. Therefore, for patients with hypertension complicated by CHD, peak morning blood pressure value should be monitored and controlled in clinical. Key words: Hypertension; Coronary heart disease; Peak morning blood pressure; Cardiovascular and cerebrovascular event; Correlation