Synthesis of New Oxazepine and Thaizolidine Compounds derived from Pyrimidine-2(2H)-one

In this paper the compounds (11-20) (methyl pyrimidine 2(1H)-one and others phenyl pyrimidine -2(1H)one) that had been already prepared from α, β unsaturated carbonyl compounds that are called chalcones, these compounds are usually prepared from the reaction of different aldehydes (4-methoxy benzaldehyde, 2-nitro benzaldehyde, 3-nitrobenzaldehyde, 4-N,N—dimethyle amino benzaldehyde, benzaldehyde, 4-nitrobenzaldehyde) with different ketones (acetone, acetophenone, 2-nitro acetophenone, 3nitro acetophenone) After preparing and purifying them a suitable mesurment for physical, chemical and spectroscopic properties had been made to get chalcones that reacted with urea under known chemical conditions to get the pyrimidinone compounds that we need. Pyrimidine compounds had been reacted with two aromatic amines (2,4dinitro aniline and 4amino acetophenone) using glacial acetic acid as catalyst in absolute ethanol giving a new compounds of schiff's bases (21-40). New thiazolidine 4-one (41-50) had been synthesized from the reacting of Schiff's bases (21-30) with thioglycolic acid in absolute ethanol. 1,3oxazepine derivatives. (51-60) had been prepared from reaction between Schiff's bases (31-40) and malic anhydrid in absolut ethanol. The structures of the Synthesized compounds had been estimated by IR, HNMR and some physical data.