Survivin和Caspase-3对胃癌细胞凋亡及预后的影响

Yi-fei Zhu, Shi-ying Zheng, J. Ge, Jun Zhao, D. Jiang
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引用次数: 25

摘要

目的:探讨survivin和caspase-3在胃癌细胞凋亡中的作用及对胃癌患者预后的影响。方法:采用免疫组织化学方法对80例无放化疗史的胃癌患者进行survivin和caspase-3的表达研究。TUNEL法检测肿瘤细胞凋亡。结果:免疫组化分析显示,80例胃癌患者中61例(76%)survivin表达阳性。而邻近正常组织中未检测到survivin的表达。caspase-3在正常组织中的表达水平高于癌组织。survivin高表达患者的组织学分级和病理分期较差。caspase-3的表达与组织学分期有显著相关性,与病理分期无显著相关性。虽然survivin在癌组织中的表达与caspase-3无负相关,但survivin(-)和caspase-3(+)的患者细胞凋亡指数最高。结论:survivin的表达水平与肿瘤的组织学分级和病理分期有关,提示survivin可能是胃癌预后不良的因素。不像caspase-3, survivin
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Influence of Survivin and Caspase-3 on Cell Apoptosis and Prognosis in Gastric Carcinoma
AIM: To evaluate the role of survivin and caspase-3 in apoptosis of gastric carcinoma, as well as in prognosis of patients with gastric carcinoma. METHODS: Expressions of survivin and caspase-3 were investigated immunohistochemically in 80 gastric carcinoma patients without a history of chemo-radiation therapy. Tumor cell apoptosis was examined by TUNEL method. RESULTS: Immunohistochemical analysis showed that survivin expression was positive in 61 of 80 patients (76%) with gastric carcinoma. In contrast, no expression of survivin in adjacent normal tissues was detected. Expression level of caspase-3 was higher in normal tissues than in carcinoma. Patients with higher expression of survivin had worse histological grades and pathological stages. Expression of caspase-3 was significantly associated with histological stages, but not with the pathological stages. Although survivin expression in carcinoma was not inversely related to caspase-3, patients with survivin (-) and caspase-3(+) had the maximum apoptosis index. CONCLUSION: Expression level of survivin was associated with histological grades and pathological stages of the tumor, indicating that survivin may be a poor prognosis factor for gastric carcinoma. Unlike caspase-3, survivin
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