Effects of selenium yeast combined with levothyroxine sodium on Hashimoto thyroiditis complicated by hypothyroidism

Objective To investigate the therapeutic effects of selenium yeast combined with levothyroxine sodium on Hashimoto thyroiditis patients with hypothyroidism. Methods The clinical data from 85 patients with Hashimoto thyroiditis and hypothyroidism admitted to Dezhou People’s Hospital from February 2018 to March 2019 were retrospectively analyzed. According to the drug treatment plans, patients were divided into the control group (42 cases treated with levothyroxine sodium) and observation group (43 cases treated with selenium yeast and levothyroxine sodium). Both groups were treated continuously for 90 d, and the clinical effects of the two groups were observed. The changes of thyroid function index, thyroid peroxidase antibody and thyroglobulin antibody of the two groups before and after treatment were compared. And the adverse reactions of the two groups were recorded. Results The total effective rate of the observation group (93.02%, 40/43) was higher than that of the control group (76.19%, 32/42), P 0.05). Conclusions Selenium yeast combined with levothyroxine sodium can effectively improve thyroid function, reduce thyroid antibodies and effectively control the incidence of adverse reactions in Hashimoto thyroiditis patients with hypothyroidism. Key words: Hashimoto thyroiditis; Hypothyroidism; Selenium yeast; Levothyroxine sodium