成人患者颅脊柱放射治疗中快速电弧治疗的剂量学研究

Arpitha S Rao
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引用次数: 0

摘要

背景:成人成神经管细胞瘤非常罕见,仅占成人中枢神经系统肿瘤的1%。由于靶体积长、不规则、关键结构和多靶区的匹配,成人CSI治疗具有挑战性。目的:对接受颅脊髓放射治疗的成年患者进行回顾性剂量学研究,以了解使用RapidArc技术治疗的挑战和优势。材料与方法:对2018年11月至2021年6月接受颅脊髓放射治疗的3例成人患者的计算机剂量学快速弧线规划数据进行研究。结果:本研究的平均一致性指数(范围)为0.95(0.91-1),平均均匀性指数(范围)为0.11(0.06-0.15)。晶状体、肺、心脏和肾脏的平均剂量分别为6.4 Gy、9.4 Gy、5 Gy和7 Gy。结论:体积调制弧线治疗技术可使靶内剂量分布适形,更好地保留正常组织,且在不移动接点的情况下,剂量分布更均匀。
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Dosimetric study of Rapid Arc therapy during Craniospinal Irradiation in Adult patients
Context: Adult medulloblastomas are very rare and constitute only 1% of the central nervous system tumors in adults. CSI treatment is challenging in adults due to the long, irregular target volume, critical structures, and field matchings due to multiple fields. Aims: This retrospective dosimetric study of adult patients who underwent Craniospinal irradiation was done to get insight into the challenges in the treatment and advantages of using RapidArc technique. Materials and Methods: The computed dosimetric rapid arc planning data of 3 adult cases who underwent Craniospinal irradiation between November 2018 and June 2021 were studied. Results: In our study mean conformity index (range) was 0.95 (0.91–1) and Mean homogeneity index (range) was 0.11 (0.06–0.15). Mean dose to the lenses, lungs, heart, and kidneys was 6.4 Gy, 9.4 Gy, 5 Gy, and 7 Gy, respectively. Conclusions: Volumetric modulated arc therapy technique for Craniospinal irradiation gives conformal dose distribution within the target, better normal tissue sparing, and more homogeneous dose distribution in the field junctions without the need to move the junction.
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27
审稿时长
11 weeks
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