卡培他滨在大鼠结肠切除术围手术期提供低毒抗肿瘤化疗:实验研究

H. Konstantinidis, Theano T. Pissanidou, A. Sioga, L. Economou, C. Demertzidis, N. Pissanidis
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摘要

背景:结直肠癌手术患者早期诱导化疗可能导致伤口愈合明显延迟,并增加脓毒性并发症的风险。卡培他滨是一种具有抗肿瘤活性的新型氟嘧啶氨基甲酸酯类药物,适用于结直肠癌的治疗。研究了结肠切除术后围手术期卡培他滨给药的影响。方法:采用卡培他滨预处理大鼠结肠切除术和手缝合结肠吻合术。60只Wistar大鼠随机分为两组,每组30只。在研究组中,从手术前1周开始,在整个研究过程中给予卡培他滨治疗剂量。对照组给予安慰剂。实验组和对照组分别于术后第3、7、14天处死大鼠,每组10只。结果:实验组动物术后体重均有所增加。未见对实验动物结肠吻合口愈合有不良影响的报道。与对照组相比,第3天处死的实验动物的中位破裂压力明显升高,组织学结果显示坏死效应较小。结论:结肠切除术期间给予卡培他滨对术前治疗动物的恢复没有负面影响,对结肠吻合口的愈合也没有负面影响。
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Capecitabine Provides Low Toxicity Antitumor Chemotherapy During Perioperative Period Of Colectomy: Experimental Study In Rats
Background: Early induction of chemotherapy in patients operated for colorectal carcinomas, may cause a significant delay in wound healing and multiply the risk of septic complications. Capecitabine is a new fluoropyrimidine carbamate with antineoplastic activity, indicated for the therapy of colorectal cancer. The impact of capecitabine administration during the perioperative period after colectomy was studied. Methods: Rats, which underwent colectomy and hand sutured colonic anastomosis, were pretreated with capecitabine. Sixty Wistar rats where randomized in two groups of 30 rats each. In the study group capecitabine was administered at therapeutic dose, from 1 week prior the operation throughout the study. Control group received placebo. Rats were sacrificed in groups of 10 animals on the 3, 7 and 14 postoperative days, in both experimental and control groups. Results: All animals of the experimental group gained weight postoperatively. No negative impact on the healing of experimental animal's colonic anastomoses was reported. The median bursting pressure was found to be significantly higher and histological findings showed less necrotic effects in experimental animals sacrificed on the 3 day, in comparison to controls. Conclusions: Administration of capecitabine during colectomy does not have a negative impact on the recovery of preoperatively treated animals, neither on the healing of colonic anastomoses.
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