决明子代谢产物的测定及抑菌活性评价

A. Al-Marzoqi, M. Hadi, I. Hameed
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Gas chromatography-mass spectrometry (GC-MS) analysis of C. angustifolia revealed the existence of the 2,5-dimethyl-4-hydroxy-3(2H)-furanon, 2-propyl-tetrahydropyran-3-ol, estragole, benzene, 1-ethynyl-4-fluoro-, 5-hydroxymethylfurfural, anethole, 7-oxabicyclo[4.1.0]heptan-2-one,6-methyl-3-(1-methylethyl)-, 2-methoxy-4-vinylphenol, 1,2,2-trimethylcyclopentane-1,3-dicarboxylic acid, E-9-tetradecenoic acid, caryophyllene, cholestan-3-ol,2-methylene-, (3s,5α)-, Benzene, 1-(1,5-dimethyl-4-hexenyl)-4-methyl-, s-curcumene, 7-epi-cis-sesquisabinene hydrate, Cyclohexene, 3-(1,5-dimethyl-4-hexenyl)-6-methylene-,[S-(R*,S*)]-m, octahydrobenzo[b]pyran, 4a-acetoxy-5,5,8a,-trimethyl, dodecanoic acid, 3-hydroxy, tetraacetyl-d-xylonic nitrile, 1-ethenyl 3, trans(1,1-dimethylethyl)-4,cis-methoxycyclohexan-1-ol, phen-1,4-diol,2,3-dimethyl-5-trifluoromethyl, 5-benzofuranacetic acid, 6-ethenyl-2,4,5,6,7,7a-hexahydro-3,6-dime, 5-benzofuranacetic acid, 6-ethenyl-2,4,5,6,7,7a-hexahydro-3,6-dime, phytol, acetate, desulphosiniqrin, oxiraneundecanoic acid, 3-pentyl-,methyl ester, cis,Phytol, 9,12,15-Octadecatrienoic acid, 2-phenyl-1,3-dioxan-5-yl ester, butanoic acid, 1a,2,5,5a,6,9,10,10a-octahydro-5,5adihydroxy-4-(h), 9-Octadecenoic acid, 1,2,3-propanetriyl ester, (E,E,E) and Diisooctyl phthalate. 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引用次数: 70

摘要

植物化学物质是通常被称为次生代谢产物的化合物。从桂叶甲醇提取物中鉴定出44种具有生物活性的植物化学成分。植物化合物的鉴定主要依据峰面积、保留时间、分子量和分子式。气相色谱-质谱联用(GC-MS)分析表明,石竹中存在2,5-二甲基-4-羟基-3(2H)-呋喃酮、2-丙基-四氢吡喃-3-醇、雌酮、苯、1-乙基-4-氟、5-羟甲基糠醛、茴香、7-氧沙环[4.1.0]-2-庚烷、6-甲基-3-(1-甲基乙基)-、2-甲氧基-4-乙烯基酚、1,2,2-三甲基环戊烷-1,3-二羧酸、e- 9-十四烯酸、石竹烯、胆甾-3-醇、2-亚甲基-、(3s,5α)-、苯、(1) - 1, 5-dimethyl-4-hexenyl 4-methyl, s-curcumene, 7-epi-cis-sesquisabinene水合物、环己烯、3 - (1,5-dimethyl-4-hexenyl) 6-methylene (S - (R, S *)] - m, octahydrobenzo [b]吡喃4 a-acetoxy-5, 5, 8,三甲基,月桂酸,3-hydroxy, tetraacetyl-d-xylonic腈,1-ethenyl 3,反式(1,1 -二甲基乙基)4,cis-methoxycyclohexan-1-ol, phen-1, 4-diol, 2, 3-dimethyl-5-trifluoromethyl, 5-benzofuranacetic酸,6-ethenyl-2, 4, 5, 6, 7, 7 a-hexahydro-3 6-dime, 5-benzofuranacetic酸,6-乙烯基-2,4,5,6,7,7 - a-六氢-3,6- 10,叶绿醇,醋酸,脱硫,氧环十一烷酸,3-戊基-甲酯,顺式,叶绿醇,9,12,15-十八碳三烯酸,2 -苯基-1,3-二氧六烷-5-酯,丁酸,1a,2,5,5a,6,9,10,10 - a-八氢-5,5 -二羟基-4-(h), 9-十八碳酸,1,2,3-丙三基酯,(E,E,E)和邻苯二甲酸二异辛酯。对地曲霉有较高的抑制活性(6.01±0.27)。关键词:抗真菌,气相色谱-质谱联用,傅里叶变换红外光谱,植物化学,决明子
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Determination of metabolites products by Cassia angustifolia and evaluate antimicobial activity
Phytochemicals are chemical compounds often referred to as secondary metabolites. Forty four bioactive phytochemical compounds were identified in the methanolic leaves extract of Cassia angustifolia. The identification of phytochemical compounds is based on the peak area, retention time molecular weight and molecular formula. Gas chromatography-mass spectrometry (GC-MS) analysis of C. angustifolia revealed the existence of the 2,5-dimethyl-4-hydroxy-3(2H)-furanon, 2-propyl-tetrahydropyran-3-ol, estragole, benzene, 1-ethynyl-4-fluoro-, 5-hydroxymethylfurfural, anethole, 7-oxabicyclo[4.1.0]heptan-2-one,6-methyl-3-(1-methylethyl)-, 2-methoxy-4-vinylphenol, 1,2,2-trimethylcyclopentane-1,3-dicarboxylic acid, E-9-tetradecenoic acid, caryophyllene, cholestan-3-ol,2-methylene-, (3s,5α)-, Benzene, 1-(1,5-dimethyl-4-hexenyl)-4-methyl-, s-curcumene, 7-epi-cis-sesquisabinene hydrate, Cyclohexene, 3-(1,5-dimethyl-4-hexenyl)-6-methylene-,[S-(R*,S*)]-m, octahydrobenzo[b]pyran, 4a-acetoxy-5,5,8a,-trimethyl, dodecanoic acid, 3-hydroxy, tetraacetyl-d-xylonic nitrile, 1-ethenyl 3, trans(1,1-dimethylethyl)-4,cis-methoxycyclohexan-1-ol, phen-1,4-diol,2,3-dimethyl-5-trifluoromethyl, 5-benzofuranacetic acid, 6-ethenyl-2,4,5,6,7,7a-hexahydro-3,6-dime, 5-benzofuranacetic acid, 6-ethenyl-2,4,5,6,7,7a-hexahydro-3,6-dime, phytol, acetate, desulphosiniqrin, oxiraneundecanoic acid, 3-pentyl-,methyl ester, cis,Phytol, 9,12,15-Octadecatrienoic acid, 2-phenyl-1,3-dioxan-5-yl ester, butanoic acid, 1a,2,5,5a,6,9,10,10a-octahydro-5,5adihydroxy-4-(h), 9-Octadecenoic acid, 1,2,3-propanetriyl ester, (E,E,E) and Diisooctyl phthalate. C. angustifolia was highly active against Aspergillus terreus (6.01±0.27). Key words: Antifungal, gas chromatography-mass spectrometry, fourier-transform infrared spectroscopy, phytochemicals, Cassia angustifolia.
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