低糖高膳食纤维面条对自发性糖尿病Torii脂肪大鼠血糖水平的影响

K. Suruga, Tsuyoshi Tomita, K. Kadokura
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引用次数: 2

摘要

背景:自2013年美国糖尿病协会推荐以来,低碳水化合物饮食一直是一种流行的营养疗法。低碳水化合物饮食对降低血糖和糖化血红蛋白水平有效。在此,我们建议经常吃面条的人使用低糖、高膳食纤维的面条作为新的饮食限制方法。本研究旨在探讨28天低糖、高膳食纤维面条(含有冈菜和魔芋)对肥胖型2型糖尿病模型——自发性糖尿病Torii脂肪大鼠血糖水平的影响。方法:7周龄雄性大鼠分为两组。ⅰ组以AIN-93G为标准饲粮(n=6)作为对照组,ⅱ组以50%的低糖高膳食纤维干面代替玉米淀粉为标准饲粮(n=6)。每周测量一次体重、食物摄入量和血糖水平,并在给药28天后分析血红蛋白A1c和糖化白蛋白水平。28 d后,大鼠禁食,给予葡萄糖(2000 mg/kg体重)进行口服葡萄糖耐量试验。结果:低糖高膳食纤维面条组的血糖、糖化血红蛋白、糖化白蛋白水平均显著低于对照组,且有体重增加。结论:本文首次报道了低糖高膳食纤维面条对模型大鼠血糖水平的影响。这种低糖、高膳食纤维的面条可能对糖尿病或乳糜泻患者有益。
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Effect of Low-Sugar and High-Dietary Fiber Noodles Diet on Blood Glucose Levels in Spontaneously Diabetic Torii Fatty Rats
Background: Low-carbohydrate diets have been a popular nutrition therapy since the American Diabetes Association’s 2013 recommendation. Low-carbohydrate diets are effective at lowering blood glucose and hemoglobin A1c levels. Here, we suggested the new diets intake restriction methods using low-sugar, high-dietary fiber noodles for those consuming noodles regularly. This study aimed to investigate the effect of a 28 day low-sugar, high-dietary fiber noodles diet, containing okara and konjac, on blood glucose levels of Spontaneously Diabetic Torii fatty rats, a model for obese type 2 diabetes. Methods: Male, 7-week-old rats were divided into two groups. Group I was fed the AIN-93G as standard diet (n=6) as control group, and group II was fed the standard diet in which 50% dried low-sugar, high-dietary fiber noodles replaced cornstarch (n=6). Body weight, food intake, and blood glucose levels were measured once a week, and hemoglobin A1c and glycated albumin levels analyzed after 28 days administration. Following the 28 days, the rats were fasted, glucose (2,000 mg/kg body weight) was administrated for the oral glucose tolerance test. Results: The blood glucose, hemoglobin A1c, and glycated albumin levels of the low-sugar, high-dietary fiber noodles group were significantly lower than those of the control group, in which body weight gain was observed. Conclusion: This is the first report on the effectiveness of low-sugar, high-dietary fiber noodles on blood glucose levels in model rats. The low-sugar, high-dietary fiber noodles might be beneficial for diabetes or celiac disease patients who consume noodles.
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