0.05%他沙罗汀凝胶与0.1%阿达帕林凝胶治疗面部寻常性痤疮的疗效对比研究

A. Deshmukh, Sanmitra Aiholli, B. Naik
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引用次数: 0

摘要

寻常痤疮是目前皮肤科诊所最常见的皮肤疾病之一。大多数患者患有轻度至中度痤疮,局部类维生素a是主要的治疗方法。目的:研究0.05%他沙罗汀凝胶对0.1%阿达帕林凝胶治疗面部寻常性痤疮的疗效和耐受性。材料与方法:82例面部寻常性痤疮患者随机分为两组。A组给予0.05%他zarotene凝胶,B组给予0.1%阿达帕林凝胶,连用8周。每15 d记录病变计数及照片。结果:他扎罗汀和阿达帕林首次随访时与基线的平均差异为6.80±6.42和1.48±10.44,p值为0.013。最终随访值分别为34.77±23.73和25.48±13.04,p值为0.051。他扎罗汀和阿达帕林自基线至末次随访的平均变化百分比分别为60%和51%,两组差异均有统计学意义(P < 0.05)。他zarotene组出现红斑、烧灼感等皮肤不良反应的患者多于阿达帕林组(P < 0.05)。结论:0.05%他沙罗汀凝胶的疗效优于0.1%阿达帕林,但副作用更大。它可以用作局部辅助或作为单一疗法在轻度至中度面部痤疮寻常。
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The comparative study to determine the efficacy of 0.05% tazarotene gel versus 0.1% adapalene gel in patients of facial acne vulgaris
Introduction: Acne vulgaris is one of the most common skin disorders that present to Dermatology clinics. The majority of the patients suffer from mild-to-moderate acne, for which topical retinoids form the mainstay of treatment. Aims and Objectives: The aim of this article is to study and determine the efficacy and tolerability of 0.05% tazarotene gel against 0.1% adapalene gel in facial acne vulgaris. Materials and Methods: Eighty-two facial acne vulgaris patients were randomly divided into two groups. Group A was given 0.05% tazarotene gel, and group B received 0.1% adapalene gel to be applied overnight for a period of 8 weeks. Lesion counting and photographs were recorded every 15 days. Results: The mean difference on first follow-up from baseline for tazarotene and adapalene was 6.80 ± 6.42 and 1.48 ± 10.44, and the P-value was 0.013. The final follow-up visit values were 34.77 ± 23.73 and 25.48 ± 13.04, with a P-value of 0.051. The mean percentage change from baseline to last follow-up for tazarotene and adapalene was 60% and 51%, respectively, which were statistically significant for both groups (P < 0.05). More patients in the tazarotene group developed cutaneous side effects such as erythema and burning sensation than those in the adapalene group (P < 0.05). conclusion: About 0.05% tazarotene gel has better efficacy than 0.1% adapalene, though associated with more side effects. It can be used as a topical adjunct or as monotherapy in mild-to-moderate facial acne vulgaris.
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13
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