{"title":"0.05%他沙罗汀凝胶与0.1%阿达帕林凝胶治疗面部寻常性痤疮的疗效对比研究","authors":"A. Deshmukh, Sanmitra Aiholli, B. Naik","doi":"10.4103/tjd.tjd_128_21","DOIUrl":null,"url":null,"abstract":"Introduction: Acne vulgaris is one of the most common skin disorders that present to Dermatology clinics. The majority of the patients suffer from mild-to-moderate acne, for which topical retinoids form the mainstay of treatment. Aims and Objectives: The aim of this article is to study and determine the efficacy and tolerability of 0.05% tazarotene gel against 0.1% adapalene gel in facial acne vulgaris. Materials and Methods: Eighty-two facial acne vulgaris patients were randomly divided into two groups. Group A was given 0.05% tazarotene gel, and group B received 0.1% adapalene gel to be applied overnight for a period of 8 weeks. Lesion counting and photographs were recorded every 15 days. Results: The mean difference on first follow-up from baseline for tazarotene and adapalene was 6.80 ± 6.42 and 1.48 ± 10.44, and the P-value was 0.013. The final follow-up visit values were 34.77 ± 23.73 and 25.48 ± 13.04, with a P-value of 0.051. The mean percentage change from baseline to last follow-up for tazarotene and adapalene was 60% and 51%, respectively, which were statistically significant for both groups (P < 0.05). More patients in the tazarotene group developed cutaneous side effects such as erythema and burning sensation than those in the adapalene group (P < 0.05). conclusion: About 0.05% tazarotene gel has better efficacy than 0.1% adapalene, though associated with more side effects. It can be used as a topical adjunct or as monotherapy in mild-to-moderate facial acne vulgaris.","PeriodicalId":42454,"journal":{"name":"Turk Dermatoloji Dergisi-Turkish Journal of Dermatology","volume":"31 1","pages":"87 - 91"},"PeriodicalIF":0.1000,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The comparative study to determine the efficacy of 0.05% tazarotene gel versus 0.1% adapalene gel in patients of facial acne vulgaris\",\"authors\":\"A. Deshmukh, Sanmitra Aiholli, B. Naik\",\"doi\":\"10.4103/tjd.tjd_128_21\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction: Acne vulgaris is one of the most common skin disorders that present to Dermatology clinics. The majority of the patients suffer from mild-to-moderate acne, for which topical retinoids form the mainstay of treatment. Aims and Objectives: The aim of this article is to study and determine the efficacy and tolerability of 0.05% tazarotene gel against 0.1% adapalene gel in facial acne vulgaris. Materials and Methods: Eighty-two facial acne vulgaris patients were randomly divided into two groups. Group A was given 0.05% tazarotene gel, and group B received 0.1% adapalene gel to be applied overnight for a period of 8 weeks. Lesion counting and photographs were recorded every 15 days. Results: The mean difference on first follow-up from baseline for tazarotene and adapalene was 6.80 ± 6.42 and 1.48 ± 10.44, and the P-value was 0.013. The final follow-up visit values were 34.77 ± 23.73 and 25.48 ± 13.04, with a P-value of 0.051. The mean percentage change from baseline to last follow-up for tazarotene and adapalene was 60% and 51%, respectively, which were statistically significant for both groups (P < 0.05). More patients in the tazarotene group developed cutaneous side effects such as erythema and burning sensation than those in the adapalene group (P < 0.05). conclusion: About 0.05% tazarotene gel has better efficacy than 0.1% adapalene, though associated with more side effects. It can be used as a topical adjunct or as monotherapy in mild-to-moderate facial acne vulgaris.\",\"PeriodicalId\":42454,\"journal\":{\"name\":\"Turk Dermatoloji Dergisi-Turkish Journal of Dermatology\",\"volume\":\"31 1\",\"pages\":\"87 - 91\"},\"PeriodicalIF\":0.1000,\"publicationDate\":\"2022-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Turk Dermatoloji Dergisi-Turkish Journal of Dermatology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/tjd.tjd_128_21\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Turk Dermatoloji Dergisi-Turkish Journal of Dermatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/tjd.tjd_128_21","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"DERMATOLOGY","Score":null,"Total":0}
The comparative study to determine the efficacy of 0.05% tazarotene gel versus 0.1% adapalene gel in patients of facial acne vulgaris
Introduction: Acne vulgaris is one of the most common skin disorders that present to Dermatology clinics. The majority of the patients suffer from mild-to-moderate acne, for which topical retinoids form the mainstay of treatment. Aims and Objectives: The aim of this article is to study and determine the efficacy and tolerability of 0.05% tazarotene gel against 0.1% adapalene gel in facial acne vulgaris. Materials and Methods: Eighty-two facial acne vulgaris patients were randomly divided into two groups. Group A was given 0.05% tazarotene gel, and group B received 0.1% adapalene gel to be applied overnight for a period of 8 weeks. Lesion counting and photographs were recorded every 15 days. Results: The mean difference on first follow-up from baseline for tazarotene and adapalene was 6.80 ± 6.42 and 1.48 ± 10.44, and the P-value was 0.013. The final follow-up visit values were 34.77 ± 23.73 and 25.48 ± 13.04, with a P-value of 0.051. The mean percentage change from baseline to last follow-up for tazarotene and adapalene was 60% and 51%, respectively, which were statistically significant for both groups (P < 0.05). More patients in the tazarotene group developed cutaneous side effects such as erythema and burning sensation than those in the adapalene group (P < 0.05). conclusion: About 0.05% tazarotene gel has better efficacy than 0.1% adapalene, though associated with more side effects. It can be used as a topical adjunct or as monotherapy in mild-to-moderate facial acne vulgaris.