Background: Scabies is a highly contagious and intensely pruritic disease of the skin. Scabies more commonly affects young children, adolescents, and the elderly. Its prevalence is highest in tropical regions, in low-and-middle-income countries, and in times of war. Materials and Methods: The study was conducted among physicians working in primary care health care settings in Ordu, Turkey. We developed a survey of 22 questions. A hard copy of the questionnaire was delivered to the physicians. Results: A total of 133 responses were obtained. 71 (53.4%) of the physicians were general practitioners (56.5%) and 62 (46.6%) of them were family physicians. 92 of them were working in clinics and 41 of them were working in emergency departments. The overall knowledge score was 83.2%. 60.2% of the physicians had a total score below median score and 39.8% were above median score. The lowest level of knowledge was associated with pathogen, transmission, and incubation period, and the highest knowledge was about clinical diagnosis. Besides, 86.5% of responders had a knowledge score of ≥75%. Physicians <30 years old had a better knowledge score. Conclusion: In conclusion, in our study the knowledge about scabies among primary care physicians was adequate, but most of the physicians reported they had difficulty in treating scabies. It is recommended to arrange training programs, including diagnosing and managing dermatological conditions including scabies for the physicians working in the primary health care services.
{"title":"Evaluating knowledge level about scabies in primary care physicians during the scabies outbreak of Turkey","authors":"Fatma Etgu, S. Onder","doi":"10.4103/tjd.tjd_116_22","DOIUrl":"https://doi.org/10.4103/tjd.tjd_116_22","url":null,"abstract":"Background: Scabies is a highly contagious and intensely pruritic disease of the skin. Scabies more commonly affects young children, adolescents, and the elderly. Its prevalence is highest in tropical regions, in low-and-middle-income countries, and in times of war. Materials and Methods: The study was conducted among physicians working in primary care health care settings in Ordu, Turkey. We developed a survey of 22 questions. A hard copy of the questionnaire was delivered to the physicians. Results: A total of 133 responses were obtained. 71 (53.4%) of the physicians were general practitioners (56.5%) and 62 (46.6%) of them were family physicians. 92 of them were working in clinics and 41 of them were working in emergency departments. The overall knowledge score was 83.2%. 60.2% of the physicians had a total score below median score and 39.8% were above median score. The lowest level of knowledge was associated with pathogen, transmission, and incubation period, and the highest knowledge was about clinical diagnosis. Besides, 86.5% of responders had a knowledge score of ≥75%. Physicians <30 years old had a better knowledge score. Conclusion: In conclusion, in our study the knowledge about scabies among primary care physicians was adequate, but most of the physicians reported they had difficulty in treating scabies. It is recommended to arrange training programs, including diagnosing and managing dermatological conditions including scabies for the physicians working in the primary health care services.","PeriodicalId":42454,"journal":{"name":"Turk Dermatoloji Dergisi-Turkish Journal of Dermatology","volume":"41 2 1","pages":"57 - 63"},"PeriodicalIF":0.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78205651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Warts are benign lesions caused by human papilloma virus. Various types of cutaneous warts include verruca vulgaris, genital warts, and palmoplantar warts. Various therapeutic modalities are available for warts with varying response. These include destructive therapies, cytotoxic agents (Bleomycin), and immunotherapy (measles, mumps, and rubella [MMR], candida antigen, etc.). We have analyzed the efficacy of intralesional MMR immunotherapy in patients with different kinds of cutaneous warts. Aim: The purpose of this study was to retrospectively analyze the effectiveness and safety of MMR immunotherapy in the treatment of different kinds of cutaneous warts. Materials and Methods: We included all the patients with cutaneous warts receiving MMR vaccine between March 2014 and March 2022. Demographic data were recorded. MMR vaccine was given for four doses at 3 weeks interval or till there was complete clearance, whichever was earlier. Clearance and reduction of wart sizes and potential side effects were recorded. Results: A total of 184 patients were enrolled, and 45% patients were women. Predominant age group of patients was 21–40 years. Most common types of warts observed was palmoplantar warts. Complete resolution was seen in 66% patients and partial response in 22% patients. Palmo-plantar and warts on extremities responded completely to immunotherapy, whereas 43% of genital warts had no improvement. Pain at injection site was observed in all patients, and 32% patients had flu-like symptoms. Conclusions: Immunotherapy with MMR vaccine shows a promising response in the treatment of palmo-plantar warts and warts on extremities, without any serious adverse effect, whereas the genital warts and verruca plana respond variably to immunotherapy.
{"title":"Retrospective analysis of treatment of cutaneous warts with measles, mumps, and rubella immunotherapy over 8 years","authors":"Ramandeep Kaur, S. Sood, I. Agrawal, B. Sharma","doi":"10.4103/tjd.tjd_107_22","DOIUrl":"https://doi.org/10.4103/tjd.tjd_107_22","url":null,"abstract":"Introduction: Warts are benign lesions caused by human papilloma virus. Various types of cutaneous warts include verruca vulgaris, genital warts, and palmoplantar warts. Various therapeutic modalities are available for warts with varying response. These include destructive therapies, cytotoxic agents (Bleomycin), and immunotherapy (measles, mumps, and rubella [MMR], candida antigen, etc.). We have analyzed the efficacy of intralesional MMR immunotherapy in patients with different kinds of cutaneous warts. Aim: The purpose of this study was to retrospectively analyze the effectiveness and safety of MMR immunotherapy in the treatment of different kinds of cutaneous warts. Materials and Methods: We included all the patients with cutaneous warts receiving MMR vaccine between March 2014 and March 2022. Demographic data were recorded. MMR vaccine was given for four doses at 3 weeks interval or till there was complete clearance, whichever was earlier. Clearance and reduction of wart sizes and potential side effects were recorded. Results: A total of 184 patients were enrolled, and 45% patients were women. Predominant age group of patients was 21–40 years. Most common types of warts observed was palmoplantar warts. Complete resolution was seen in 66% patients and partial response in 22% patients. Palmo-plantar and warts on extremities responded completely to immunotherapy, whereas 43% of genital warts had no improvement. Pain at injection site was observed in all patients, and 32% patients had flu-like symptoms. Conclusions: Immunotherapy with MMR vaccine shows a promising response in the treatment of palmo-plantar warts and warts on extremities, without any serious adverse effect, whereas the genital warts and verruca plana respond variably to immunotherapy.","PeriodicalId":42454,"journal":{"name":"Turk Dermatoloji Dergisi-Turkish Journal of Dermatology","volume":"28 1","pages":"64 - 68"},"PeriodicalIF":0.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82585384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Basal cell carcinoma and squamous cell carcinoma constitute the majority of nonmelanoma skin cancers. In our study, we analyzed our results of nonmelanoma skin cancer treatment with 5-mm surgical excision and compared them with the literature. Material and Methods: Patients treated at Ankara City Hospital Plastic, Reconstructive, and Aesthetic Surgery Clinic between February 2019 and March 2022 were included in this study. Demographic data, anatomical region, tumor subtype/differentiation, surgical margins, reconstruction method, and recurrence parameters were recorded. IBM SPSS Statistics (version 26.0) was used for the data analysis. Results: Of the 234 cases, 163 were reported as basal cell and 71 as squamous cell cancer. Margin positivity with 5-mm surgical excision was 14.1% and 16.9% in basal and squamous cell cancer, respectively. Nineth-month recurrence rates were 4.2% and 19.7% in basal and squamous cell cancer, respectively. Conclusions: All surgical margin positivity and recurrences were located in the head and neck regions, revealing the importance of developing treatment references according to the anatomical region.
{"title":"Treatment results with 5-mm surgical excision in nonmelanoma skin cancers: Analysis of 234 cases","authors":"M. Sonmez, Omer Yikilmaz, R. Unlu","doi":"10.4103/tjd.tjd_120_22","DOIUrl":"https://doi.org/10.4103/tjd.tjd_120_22","url":null,"abstract":"Background: Basal cell carcinoma and squamous cell carcinoma constitute the majority of nonmelanoma skin cancers. In our study, we analyzed our results of nonmelanoma skin cancer treatment with 5-mm surgical excision and compared them with the literature. Material and Methods: Patients treated at Ankara City Hospital Plastic, Reconstructive, and Aesthetic Surgery Clinic between February 2019 and March 2022 were included in this study. Demographic data, anatomical region, tumor subtype/differentiation, surgical margins, reconstruction method, and recurrence parameters were recorded. IBM SPSS Statistics (version 26.0) was used for the data analysis. Results: Of the 234 cases, 163 were reported as basal cell and 71 as squamous cell cancer. Margin positivity with 5-mm surgical excision was 14.1% and 16.9% in basal and squamous cell cancer, respectively. Nineth-month recurrence rates were 4.2% and 19.7% in basal and squamous cell cancer, respectively. Conclusions: All surgical margin positivity and recurrences were located in the head and neck regions, revealing the importance of developing treatment references according to the anatomical region.","PeriodicalId":42454,"journal":{"name":"Turk Dermatoloji Dergisi-Turkish Journal of Dermatology","volume":"21 1","pages":"69 - 72"},"PeriodicalIF":0.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81037696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rajkiran Takharya, Jude E. Dileep, P. Oudeacoumar, D. Kaliyaperumal, Ilakkia P. Sadasivam, L. Dsouza
Background: Chemical peel is a cosmetic procedure that is becoming a popular modality in treating acne vulgaris (AV). Mandelic acid (MA) is an upcoming peeling agent for AV due to its anti-inflammatory and antibacterial traits. Hence, it is worthwhile to appraise this newer agent’s effectiveness and safety profile and compare it with a more traditional and established peeling agent, salicylic acid (SA), in the treatment of AV. Aims: The aim of this study was to compare the efficacy of 40% MA with 30% SA peels in south Indian patients suffering from mild-to-moderate facial AV. Materials and Methods: One hundred patients suffering from mild-to-moderate facial AV were distributed randomly into two groups of 50 each, with group A receiving 40% MA peel and group B receiving 30% SA peel at an interval of two weeks for six sessions. The duration of the study was twelve weeks. Clinical pictures and Michaelsson acne scores (MAS) were used to evaluate the effectiveness of treatment objectively. Adverse effects of both the peeling agents were also noted. Statistical Analysis Used: A value of P ≤ 0.05 was considered significant. Results: Overall, there was no significant difference in the efficacy between the two peels. However, adverse effects were slightly higher with SA peel. Conclusions: The 40% MA peel was equally effective as 30% SA peel in mild-to-moderate facial AV. However, safety profile and tolerability were better in the MA peel group than the SA peel group.
{"title":"Comparison of efficacy of 40% mandelic acid with 30% salicylic acid peels in mild-to-moderate acne vulgaris: A randomized study","authors":"Rajkiran Takharya, Jude E. Dileep, P. Oudeacoumar, D. Kaliyaperumal, Ilakkia P. Sadasivam, L. Dsouza","doi":"10.4103/tjd.tjd_106_22","DOIUrl":"https://doi.org/10.4103/tjd.tjd_106_22","url":null,"abstract":"Background: Chemical peel is a cosmetic procedure that is becoming a popular modality in treating acne vulgaris (AV). Mandelic acid (MA) is an upcoming peeling agent for AV due to its anti-inflammatory and antibacterial traits. Hence, it is worthwhile to appraise this newer agent’s effectiveness and safety profile and compare it with a more traditional and established peeling agent, salicylic acid (SA), in the treatment of AV. Aims: The aim of this study was to compare the efficacy of 40% MA with 30% SA peels in south Indian patients suffering from mild-to-moderate facial AV. Materials and Methods: One hundred patients suffering from mild-to-moderate facial AV were distributed randomly into two groups of 50 each, with group A receiving 40% MA peel and group B receiving 30% SA peel at an interval of two weeks for six sessions. The duration of the study was twelve weeks. Clinical pictures and Michaelsson acne scores (MAS) were used to evaluate the effectiveness of treatment objectively. Adverse effects of both the peeling agents were also noted. Statistical Analysis Used: A value of P ≤ 0.05 was considered significant. Results: Overall, there was no significant difference in the efficacy between the two peels. However, adverse effects were slightly higher with SA peel. Conclusions: The 40% MA peel was equally effective as 30% SA peel in mild-to-moderate facial AV. However, safety profile and tolerability were better in the MA peel group than the SA peel group.","PeriodicalId":42454,"journal":{"name":"Turk Dermatoloji Dergisi-Turkish Journal of Dermatology","volume":"14 1","pages":"44 - 51"},"PeriodicalIF":0.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81693991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Bilgic, Kifayat Mammadli, C. Başsorgun, E. Alpsoy
Hidradenitis suppurativa (HS) is considered a primary disease of the hair follicle. The chronic occlusion of the follicular pilosebaceous unit and an associated immune response appears to be the main causes. The chronic, active, and poorly controlled disease may lead to several complications such as scars, contractures, lymphedema, osteomyelitis, and squamous cell carcinoma (SCC). We report here a 33-year-old male with HS who developed keratoacanthoma while on secukinumab treatment. The tumor representing 2 weeks of evolution in an area affected by HS (lower abdomen) was followed up after histopathological confirmation. Almost complete spontaneous regression was observed at the subsequent visits. As far as we are aware, solitary keratoacanthoma associated with HS has not been previously described. Our case shows that squamous differentiation is not limited to SCC and can develop from any scar tissue outside the anogenital region in patients with HS. Thus, the case presented here emphasizes the necessity of careful examination in scar areas as well as inflammatory lesions in HS.
{"title":"Keratoacanthoma seen with hidradenitis suppurativa: A case report","authors":"A. Bilgic, Kifayat Mammadli, C. Başsorgun, E. Alpsoy","doi":"10.4103/tjd.tjd_131_22","DOIUrl":"https://doi.org/10.4103/tjd.tjd_131_22","url":null,"abstract":"Hidradenitis suppurativa (HS) is considered a primary disease of the hair follicle. The chronic occlusion of the follicular pilosebaceous unit and an associated immune response appears to be the main causes. The chronic, active, and poorly controlled disease may lead to several complications such as scars, contractures, lymphedema, osteomyelitis, and squamous cell carcinoma (SCC). We report here a 33-year-old male with HS who developed keratoacanthoma while on secukinumab treatment. The tumor representing 2 weeks of evolution in an area affected by HS (lower abdomen) was followed up after histopathological confirmation. Almost complete spontaneous regression was observed at the subsequent visits. As far as we are aware, solitary keratoacanthoma associated with HS has not been previously described. Our case shows that squamous differentiation is not limited to SCC and can develop from any scar tissue outside the anogenital region in patients with HS. Thus, the case presented here emphasizes the necessity of careful examination in scar areas as well as inflammatory lesions in HS.","PeriodicalId":42454,"journal":{"name":"Turk Dermatoloji Dergisi-Turkish Journal of Dermatology","volume":"4 1","pages":"73 - 75"},"PeriodicalIF":0.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74836891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lumps and bumps over vulva","authors":"Samruddhi Chopkar, B. Supekar, J. Mukhi","doi":"10.4103/tjd.tjd_11_23","DOIUrl":"https://doi.org/10.4103/tjd.tjd_11_23","url":null,"abstract":"","PeriodicalId":42454,"journal":{"name":"Turk Dermatoloji Dergisi-Turkish Journal of Dermatology","volume":"32 1","pages":"76 - 77"},"PeriodicalIF":0.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88185797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Ferhatosmanoğlu, L. Selcuk, D. Arıca, Okan Kapan
Introduction: Demodex (D.) mites play a role in the etiology of many dermatological diseases. Objectives: The aim of this study was to reveal the relationship between acne severity (mild, moderate, and severe acne) and Demodex density in patients with acne vulgaris and compare this with the healthy population. Materials and Methods: In total 150 patients with acne vulgaris and 60 healthy individuals were evaluated. Patients diagnosed with acne vulgaris were divided into three groups as mild, moderate, and severe. The gender, body mass index, history of diabetes mellitus, smoking, alcohol use, tea and coffee consumption, usage frequency of moisturizer, facial cleanser and concealer, and skin type (dry/sensitive, mixed, and oily) were recorded. Demodex density was measured by using the standard superficial skin biopsy method. Results: Demodex infestation was observed in 40 (26.6%) of the acne patients and 13 (21.6%) of the healthy control group. The Demodex infestation was observed in 16 (32%) of the mild acne group, 15 (30%) of the moderate acne group, and 9 (18%) of the severe acne group; there was no significant difference between the control group and severity of acne. In patients with acne, being over 25 years of age 2.6-fold, sensitive-dry skin type 7.4-fold, and obesity 4.06-fold increased risk of Demodex infestation. Conclusion: In this study, we did not detect an increased incidence of Demodex, including disease severity, in patients with acne vulgaris. However, we showed that the density of Demodex was increased in those aged 25 years and older, obese patients, and those with sensitive-dry skin in patients with acne.
{"title":"The relationship of Demodex density with acne severity","authors":"A. Ferhatosmanoğlu, L. Selcuk, D. Arıca, Okan Kapan","doi":"10.4103/tjd.tjd_125_22","DOIUrl":"https://doi.org/10.4103/tjd.tjd_125_22","url":null,"abstract":"Introduction: Demodex (D.) mites play a role in the etiology of many dermatological diseases. Objectives: The aim of this study was to reveal the relationship between acne severity (mild, moderate, and severe acne) and Demodex density in patients with acne vulgaris and compare this with the healthy population. Materials and Methods: In total 150 patients with acne vulgaris and 60 healthy individuals were evaluated. Patients diagnosed with acne vulgaris were divided into three groups as mild, moderate, and severe. The gender, body mass index, history of diabetes mellitus, smoking, alcohol use, tea and coffee consumption, usage frequency of moisturizer, facial cleanser and concealer, and skin type (dry/sensitive, mixed, and oily) were recorded. Demodex density was measured by using the standard superficial skin biopsy method. Results: Demodex infestation was observed in 40 (26.6%) of the acne patients and 13 (21.6%) of the healthy control group. The Demodex infestation was observed in 16 (32%) of the mild acne group, 15 (30%) of the moderate acne group, and 9 (18%) of the severe acne group; there was no significant difference between the control group and severity of acne. In patients with acne, being over 25 years of age 2.6-fold, sensitive-dry skin type 7.4-fold, and obesity 4.06-fold increased risk of Demodex infestation. Conclusion: In this study, we did not detect an increased incidence of Demodex, including disease severity, in patients with acne vulgaris. However, we showed that the density of Demodex was increased in those aged 25 years and older, obese patients, and those with sensitive-dry skin in patients with acne.","PeriodicalId":42454,"journal":{"name":"Turk Dermatoloji Dergisi-Turkish Journal of Dermatology","volume":"4034 3 1","pages":"52 - 56"},"PeriodicalIF":0.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86724935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abhishek Lachure, Bhabani S T P Singh, B. Kar, Liza Mohapatra, Nibedita Dixit
Introduction: Dermatophytosis is a superficial fungal infection of keratinized tissue caused by dermatophytes. The use of itraconazole in the standard dose and duration is commonly resulting in treatment failure. Aims and Objectives: To compare the efficacy and safety of three different dosage regimens of itraconazole in the treatment of dermatophytosis. Materials and Methods: Patients were enrolled and randomly assigned to three different groups A, B, and C after obtaining the proper consent. For four weeks, patients in Groups A, B, and C received itraconazole 100 mg once daily, 200 mg once daily, and 5 mg/kg or 400 mg daily, whichever was lesser, in two divided doses, respectively. All patients were advised to use topical eberconazole cream twice daily and levocetirizine 5 mg daily. Potassium hydroxide (KOH), culture for fungus, complete blood count (CBC), and liver function test (LFT) were done at the baseline visit and repeated in 4 weeks. A clinical assessment was done at both visits. Result: KOH was negative for fungal elements in 21.4%, 19%, and 17% of patients in groups A, B, and C respectively, after the completion of therapy. The culture was negative for fungal elements in 19%, 17.5%, and 19.5% of patients in groups A, B, and C respectively, post-therapy. At the end of four weeks, there was a statistically significant decrease in lesion count, body surface area involvement, erythema, and itching within all three groups. However, after 4 weeks of therapy, there was no significant difference in clinical outcome or mycological status among the three groups. Conclusion: Our study concludes that the higher dose of itraconazole does not prove to be more efficacious and has no added advantage over the conventional dose in the treatment of dermatophytosis at the end of four weeks. Therefore, we suggest for long-term (more than 4 weeks) itraconazole therapy with the conventional dose to achieve an adequate cure.
{"title":"Randomized control trial of itraconazole in the treatment of dermatophytosis: comparison of three different dose regimens","authors":"Abhishek Lachure, Bhabani S T P Singh, B. Kar, Liza Mohapatra, Nibedita Dixit","doi":"10.4103/tjd.tjd_124_22","DOIUrl":"https://doi.org/10.4103/tjd.tjd_124_22","url":null,"abstract":"Introduction: Dermatophytosis is a superficial fungal infection of keratinized tissue caused by dermatophytes. The use of itraconazole in the standard dose and duration is commonly resulting in treatment failure. Aims and Objectives: To compare the efficacy and safety of three different dosage regimens of itraconazole in the treatment of dermatophytosis. Materials and Methods: Patients were enrolled and randomly assigned to three different groups A, B, and C after obtaining the proper consent. For four weeks, patients in Groups A, B, and C received itraconazole 100 mg once daily, 200 mg once daily, and 5 mg/kg or 400 mg daily, whichever was lesser, in two divided doses, respectively. All patients were advised to use topical eberconazole cream twice daily and levocetirizine 5 mg daily. Potassium hydroxide (KOH), culture for fungus, complete blood count (CBC), and liver function test (LFT) were done at the baseline visit and repeated in 4 weeks. A clinical assessment was done at both visits. Result: KOH was negative for fungal elements in 21.4%, 19%, and 17% of patients in groups A, B, and C respectively, after the completion of therapy. The culture was negative for fungal elements in 19%, 17.5%, and 19.5% of patients in groups A, B, and C respectively, post-therapy. At the end of four weeks, there was a statistically significant decrease in lesion count, body surface area involvement, erythema, and itching within all three groups. However, after 4 weeks of therapy, there was no significant difference in clinical outcome or mycological status among the three groups. Conclusion: Our study concludes that the higher dose of itraconazole does not prove to be more efficacious and has no added advantage over the conventional dose in the treatment of dermatophytosis at the end of four weeks. Therefore, we suggest for long-term (more than 4 weeks) itraconazole therapy with the conventional dose to achieve an adequate cure.","PeriodicalId":42454,"journal":{"name":"Turk Dermatoloji Dergisi-Turkish Journal of Dermatology","volume":"23 1","pages":"37 - 43"},"PeriodicalIF":0.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81252566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pallavi Phadnis, S. Rathoriya, Rochit Singhal, V. Choudhary
Lentigines are hyperpigmented macules, which represent the simplest form of increased melanocytic proliferation. The term “lentiginosis” is applied for the presence of lentigines in an exceptionally large number or in a distinctive configuration. Lentigines evolve slowly, but widespread occurrence over a short period of time is typical of eruptive lentiginosis. We report an unusual case of eruptive lentiginosis in a female patient with no prior systemic disorder or familial pattern, presenting with widespread hyperpigmented macules, symmetrically distributed over the face, neck, upper trunk, shoulders, and both arms and forearms. Clinicohistopathological features were consistent with eruptive lentiginosis. Our case report seems interesting as well as a rare one as it involved an otherwise healthy young woman.
{"title":"Eruptive lentiginosis in a young healthy woman—Revisiting causal associations","authors":"Pallavi Phadnis, S. Rathoriya, Rochit Singhal, V. Choudhary","doi":"10.4103/tjd.tjd_123_22","DOIUrl":"https://doi.org/10.4103/tjd.tjd_123_22","url":null,"abstract":"Lentigines are hyperpigmented macules, which represent the simplest form of increased melanocytic proliferation. The term “lentiginosis” is applied for the presence of lentigines in an exceptionally large number or in a distinctive configuration. Lentigines evolve slowly, but widespread occurrence over a short period of time is typical of eruptive lentiginosis. We report an unusual case of eruptive lentiginosis in a female patient with no prior systemic disorder or familial pattern, presenting with widespread hyperpigmented macules, symmetrically distributed over the face, neck, upper trunk, shoulders, and both arms and forearms. Clinicohistopathological features were consistent with eruptive lentiginosis. Our case report seems interesting as well as a rare one as it involved an otherwise healthy young woman.","PeriodicalId":42454,"journal":{"name":"Turk Dermatoloji Dergisi-Turkish Journal of Dermatology","volume":"4 1","pages":"28 - 31"},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75428476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kalgi D. Baxi, Drumil Majmundar, P. Agarwal, Ranjan Raval, Malhar Shah
Surgery of the knee, injury to the infrapatellar branch of the saphenous nerve, traumatic eczematous dermatitis (SKINTED) is a regional dermatitis specific to total knee arthroplasty, occurring postsurgically. It is characterized by an eczematous eruption localized to the knee, mostly the anteroinferior aspect, presenting as pruritic, dry, erythematous, scaly, or at times papulovesicular lesions. Having been known over the past decade by various nomenclatures, the basic pathogenesis has now been agreed upon as a locoregional immune dysfunction because of damage to lymphatics occurring postsurgically. We have described three case reports of typical eczematous lesions occurring after total knee replacement surgery and reviewed the literature for similar cases described across the literature. A PubMed and Google Scholar search pertaining to the articles published with the keywords “SKINTED” and “autonomic denervation dermatitis” was conducted. A total of 10 results were obtained after exclusion of duplicated and irrelevant search results. This yielded one review article, one original article, seven case reports, and two correspondence articles. Based on the review, the authors agree with the concept of Rucco’s immunocompromised district, being the most logical explanation for the occurrence of SKINTED. SKINTED should be differentiated from implant eczema occurring because of hypersensitivity to metal implants, which presents as systematized contact dermatitis and has a predefined set of diagnostic criteria.
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