MREIT在人体头部组织电导率重建中的应用

Dan-dan Yan, Jing Li
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引用次数: 0

摘要

利用磁共振电阻抗断层扫描(MREIT)对人体头部组织的非均匀电导率进行了重建。MREIT是一种结合电流密度成像(CDI)和传统电阻抗断层成像(EIT)技术的非侵入性电导率成像方式。MREIT是为了解决传统EIT中众所周知的不适定问题而设计的,已被用于重建人体头部组织的电导率。基于六面体单元和四面体单元,分别建立了包含头皮、颅骨、脑脊液、灰质和白质等5个组织的真实几何有限元头部模型。仿真中采用了j代入MREIT算法,该算法易于实现。仿真结果表明,结合真实几何有限元头部模型的MREIT算法可以较好地重建非均匀的人体头部组织电导率分布。到目前为止,我们的工作表明,所提出的MREIT算法可以为解决EEG/MEG正/逆问题提供有用的电导率信息,并为使用MREIT进一步研究人类头部组织提供有用的电导率信息。
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Conductivity Reconstruction of Human Head Tissues by Means of MREIT
This paper focuses on the inhomogeneous conductivity reconstruction of human head tissues by means of magnetic resonance electrical impedance tomography (MREIT). MREIT is a recently introduced and non-invasive conductivity imaging modality that combines Current Density Imaging (CDI) and traditional Electrical Impedance Tomography (EIT) techniques. MREIT, designed to deal with the well-known ill-posed problem in traditional EIT, has been applied to reconstruct the conductivities of human head tissues. We have developed two realistic geometry finite element method (FEM) head models, with five tissues including the scalp, skull, CSF, gray matter and white matter, based on the hexahedral element and the tetrahedral element, respectively. The J-substitution MREIT algorithm is used in our simulation for its easy realization. The present simulation results show that the MREIT algorithm combined with the realistic geometry FEM head model can reconstruct the inhomogeneous human head tissue conductivity distributions with higher accuracy. Our work so far suggests that the proposed MREIT algorithms can provide useful conductivity information for solving the EEG/MEG forward/inverse problems, and for further investigations on human head tissues using MREIT.
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