托吡酯诱导锂毒性

Afaque H Khan
{"title":"托吡酯诱导锂毒性","authors":"Afaque H Khan","doi":"10.15406/JSRT.2018.04.00104","DOIUrl":null,"url":null,"abstract":"Numerous studies have described that mechanism of action of Topiramate has wide spectrum pharmacological properties. He has been used as mood stabilizers in bipolar and schizoaffective disorder, anorexia bulimia, epilepsy, migraine, essential tremors and cluster headache. It is also effective in treatment resistant bipolar disorder by augmentation of effects of lithium. It has been reported in recent literature that topiramate also use in binge eating disorder (BED) and for weight loss [1]. Topiramate reduces the frequency of the voltage sensitive sodium channels and play a key role in treatment of epilepsy. Topiramate potentiates the effects of inhibitory effects of Gama amino butyric acid-A in the brain. Topiramate has been also found, enhance the effects of Gaba stimulated chloride influx in cerebral which also increase frequency of activation of Gaba-A receptor in brain and exhibits an anticonvulsants action. Topiramate is also known to have inhibitory action on excitatory pathways of AMPA and glutamate receptors and contributes as an anticonvulsant agent. TPM also inhibits high voltage activated calcium channels and decrease their neurotransmitter release and inhibit calcium dependent second messenger system. TPM also has inhibitory action at carbonic anhydrate at proximal tubular level. TPM has been considered weak CAinhibitor and this property has no therapeutic values in treatment of epilepsy and other conditions. This action determines some of its side effects such as hyponatremia, metabolic acidosis and increase risk of nephrolithiasis [2].","PeriodicalId":91560,"journal":{"name":"Journal of stem cell research & therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Topiramate induced lithium toxicity\",\"authors\":\"Afaque H Khan\",\"doi\":\"10.15406/JSRT.2018.04.00104\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Numerous studies have described that mechanism of action of Topiramate has wide spectrum pharmacological properties. He has been used as mood stabilizers in bipolar and schizoaffective disorder, anorexia bulimia, epilepsy, migraine, essential tremors and cluster headache. It is also effective in treatment resistant bipolar disorder by augmentation of effects of lithium. It has been reported in recent literature that topiramate also use in binge eating disorder (BED) and for weight loss [1]. Topiramate reduces the frequency of the voltage sensitive sodium channels and play a key role in treatment of epilepsy. Topiramate potentiates the effects of inhibitory effects of Gama amino butyric acid-A in the brain. Topiramate has been also found, enhance the effects of Gaba stimulated chloride influx in cerebral which also increase frequency of activation of Gaba-A receptor in brain and exhibits an anticonvulsants action. Topiramate is also known to have inhibitory action on excitatory pathways of AMPA and glutamate receptors and contributes as an anticonvulsant agent. TPM also inhibits high voltage activated calcium channels and decrease their neurotransmitter release and inhibit calcium dependent second messenger system. TPM also has inhibitory action at carbonic anhydrate at proximal tubular level. TPM has been considered weak CAinhibitor and this property has no therapeutic values in treatment of epilepsy and other conditions. This action determines some of its side effects such as hyponatremia, metabolic acidosis and increase risk of nephrolithiasis [2].\",\"PeriodicalId\":91560,\"journal\":{\"name\":\"Journal of stem cell research & therapeutics\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of stem cell research & therapeutics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15406/JSRT.2018.04.00104\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of stem cell research & therapeutics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15406/JSRT.2018.04.00104","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

大量研究表明托吡酯的作用机制具有广谱的药理特性。他被用作双相情感障碍和分裂情感障碍、厌食性贪食症、癫痫、偏头痛、原发性震颤和丛集性头痛的情绪稳定剂。它也是有效的治疗顽固性双相情感障碍通过增加锂的作用。最近有文献报道托吡酯也用于暴食症(BED)和减肥[1]。托吡酯降低电压敏感钠通道的频率,在癫痫治疗中发挥关键作用。托吡酯增强了γ氨基丁酸- a在大脑中的抑制作用。还发现托吡酯能增强Gaba刺激氯离子流入大脑的作用,增加Gaba- a受体在大脑中的激活频率,并表现出抗惊厥作用。托吡酯也已知对AMPA和谷氨酸受体的兴奋通路有抑制作用,并作为抗惊厥剂起作用。TPM还能抑制高压激活的钙通道,减少其神经递质释放,抑制钙依赖性第二信使系统。TPM对近端小管水平的无水碳也有抑制作用。TPM一直被认为是弱抑制剂,这种特性在治疗癫痫和其他疾病方面没有治疗价值。这一作用决定了它的一些副作用,如低钠血症、代谢性酸中毒和增加肾结石的风险[2]。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Topiramate induced lithium toxicity
Numerous studies have described that mechanism of action of Topiramate has wide spectrum pharmacological properties. He has been used as mood stabilizers in bipolar and schizoaffective disorder, anorexia bulimia, epilepsy, migraine, essential tremors and cluster headache. It is also effective in treatment resistant bipolar disorder by augmentation of effects of lithium. It has been reported in recent literature that topiramate also use in binge eating disorder (BED) and for weight loss [1]. Topiramate reduces the frequency of the voltage sensitive sodium channels and play a key role in treatment of epilepsy. Topiramate potentiates the effects of inhibitory effects of Gama amino butyric acid-A in the brain. Topiramate has been also found, enhance the effects of Gaba stimulated chloride influx in cerebral which also increase frequency of activation of Gaba-A receptor in brain and exhibits an anticonvulsants action. Topiramate is also known to have inhibitory action on excitatory pathways of AMPA and glutamate receptors and contributes as an anticonvulsant agent. TPM also inhibits high voltage activated calcium channels and decrease their neurotransmitter release and inhibit calcium dependent second messenger system. TPM also has inhibitory action at carbonic anhydrate at proximal tubular level. TPM has been considered weak CAinhibitor and this property has no therapeutic values in treatment of epilepsy and other conditions. This action determines some of its side effects such as hyponatremia, metabolic acidosis and increase risk of nephrolithiasis [2].
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Echinacea purpurea, a pathway to increased immunity Inhibition of cancer promoting proteins An in-vitro study of Amniotic membrane, Villous chorion and Wharton’s jelly-derived Mesenchymal stem cells and their potential for cardiac repair Attempt to regenerate the dog’s tooth using the method of a new direction in biology‒Linguistic‒Wave Genetics Prevention and treatment of cerebral palsy caused by intrapartum damage with novel hypoxia index
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1