A. M. Inshakova, E. Darnotuk, A. Shipelova, N. Shastina, O. Baranova, A. Chekanov, K. Kazarinov, E. Solovieva, A. Fedin
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NANODISPERSIONS OF LIPOIC ACID: PRODUCTION AND STUDY OF INFLUENCE ON FUNCTIONAL ACTIVITY OF PLATELETS
Various nanodispersions (liposomes and nanoemulsions) with lipoic acid (LA) with size of particles 50-250 nm were obtained and characterized by 80±10% encapsulation efficiency (EI) of LA into NPs, its slow release from nanoconstructions, and possessing stability during long-term storage at room temperature. It was revealed that liposomes and LA NPs inhibit platelet aggregation caused by arachidonic acid, and the mechanism of antiplatelet action was proposed.
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