{"title":"奥氮平与利培酮治疗期间血脂变化的比较","authors":"Amita Gupta, A. Jadhav, Vaibhav Dubey","doi":"10.21276/IJLSSR.2017.3.5.3","DOIUrl":null,"url":null,"abstract":"Background: Several studies demonstrated relationship between dyslipidemia and various antipsychotic drugs after treatment of psychotic disorders. Our study aimed to compare the effects of commonly prescribed antipsychotic drugs Risperidone and Olanzapine on serum lipid profile of psychiatric patients. Methods: This current study was conducted on 30 psychiatric patients, divided into two groups according to the antipsychotic drug prescribed by doctor Risperidone or Olanzapine. All the patients were assessed for changes in serum lipid profile Total cholesterol (TC), Triglycerides (TG), High Density Lipoprotein (HDL-C), Low Density Lipoprotein (LDL-C), Very Low Density Lipoprotein (VLDL-C) & Risk Factors for coronary artery disease (CAD Risk Factor I &II) after 16 weeks of treatment. Results: Patients taking Olanzapine therapy were showed significant (p<0.05) increase in all lipid parameters, whereas Risperidone treated patients has shown a significant increase in serum triglyceride and VLDL-C only. Conclusion: Olanzapine therapy is strongly associated with dyslipidemia than Risperidone. Key-wordsDyslipidemia, Lipid profile, Coronary artery disease, Risk factors, Schizophrenia","PeriodicalId":22509,"journal":{"name":"The International Journal of Life-Sciences Scientific Research","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Comparison of Serum Lipid Profile Changes during Treatment of Olanzapine and Risperidone\",\"authors\":\"Amita Gupta, A. Jadhav, Vaibhav Dubey\",\"doi\":\"10.21276/IJLSSR.2017.3.5.3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Several studies demonstrated relationship between dyslipidemia and various antipsychotic drugs after treatment of psychotic disorders. Our study aimed to compare the effects of commonly prescribed antipsychotic drugs Risperidone and Olanzapine on serum lipid profile of psychiatric patients. Methods: This current study was conducted on 30 psychiatric patients, divided into two groups according to the antipsychotic drug prescribed by doctor Risperidone or Olanzapine. All the patients were assessed for changes in serum lipid profile Total cholesterol (TC), Triglycerides (TG), High Density Lipoprotein (HDL-C), Low Density Lipoprotein (LDL-C), Very Low Density Lipoprotein (VLDL-C) & Risk Factors for coronary artery disease (CAD Risk Factor I &II) after 16 weeks of treatment. Results: Patients taking Olanzapine therapy were showed significant (p<0.05) increase in all lipid parameters, whereas Risperidone treated patients has shown a significant increase in serum triglyceride and VLDL-C only. Conclusion: Olanzapine therapy is strongly associated with dyslipidemia than Risperidone. Key-wordsDyslipidemia, Lipid profile, Coronary artery disease, Risk factors, Schizophrenia\",\"PeriodicalId\":22509,\"journal\":{\"name\":\"The International Journal of Life-Sciences Scientific Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The International Journal of Life-Sciences Scientific Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21276/IJLSSR.2017.3.5.3\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The International Journal of Life-Sciences Scientific Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21276/IJLSSR.2017.3.5.3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Comparison of Serum Lipid Profile Changes during Treatment of Olanzapine and Risperidone
Background: Several studies demonstrated relationship between dyslipidemia and various antipsychotic drugs after treatment of psychotic disorders. Our study aimed to compare the effects of commonly prescribed antipsychotic drugs Risperidone and Olanzapine on serum lipid profile of psychiatric patients. Methods: This current study was conducted on 30 psychiatric patients, divided into two groups according to the antipsychotic drug prescribed by doctor Risperidone or Olanzapine. All the patients were assessed for changes in serum lipid profile Total cholesterol (TC), Triglycerides (TG), High Density Lipoprotein (HDL-C), Low Density Lipoprotein (LDL-C), Very Low Density Lipoprotein (VLDL-C) & Risk Factors for coronary artery disease (CAD Risk Factor I &II) after 16 weeks of treatment. Results: Patients taking Olanzapine therapy were showed significant (p<0.05) increase in all lipid parameters, whereas Risperidone treated patients has shown a significant increase in serum triglyceride and VLDL-C only. Conclusion: Olanzapine therapy is strongly associated with dyslipidemia than Risperidone. Key-wordsDyslipidemia, Lipid profile, Coronary artery disease, Risk factors, Schizophrenia
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