化合物(E)-1-(3-溴苯基)-3-对甲基丙基-2-烯-1-on的合成、抗氧化及毒性活性

Proceedings of the 1st International Conference on Chemical Science and Technology Innovation Pub Date : 2019-01-01 DOI:10.5220/0008836400050009

E. M. Brahmana, J. Kaban, G. Haro, J. Tarigan, B. Wirjosentono, Tamrin, M. Ginting

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摘要

以4-甲基苯甲醛为醛，以3-溴苯酮为酮，采用醛醇缩合反应合成了卤素取代类似物查尔酮(E)-1-(3-溴苯基)-3-对-甲基丙基-2-烯-1-on。结果表明，化合物的还原值为62,38%，并通过紫外、红外、质谱和核磁共振进行了表征。DPPH法测定其抗氧化活性，LC50值为571,7903 ppm，为低效抗氧化剂。用卤虾致死试验(BSLT)进行的毒性试验表明，这些化合物具有LC50值的抗癌作用

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Synthesis, Antioxidant and Toxicity Activity of Compounds (E)-1-(3-bromophenyl)-3-p tolylprop-2-en-1-on

Halogen substituted analog compound chalcone (E)-1-(3-bromophenyl)-3-p-tolylprop-2-en-1-on was synthesized from 4-metylbenzaldehyde as aldehydes with 3bromoacetophenone, as ketones by using aldol condensation reaction. The compound resulted rendement with value of 62,38% and characterized by using UV, IR, MS, and 1HNMR. Test of antioxidant activity using DPPH method showed that those compounds have low potency as antioxidant agent LC50 with value 571, 7903 ppm. Toxicity tests using Brine Shrimp Lethality Test (BSLT) showed that those compounds have a potency as anticancer agent with LC50 value

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Proceedings of the 1st International Conference on Chemical Science and Technology Innovation

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