{"title":"新型kappa激动剂中枢和外周镇痛作用的比较","authors":"V. Batrakov, D. D. Shamshina, A. Ivanov","doi":"10.15688/JVOLSU11.2018.1.5","DOIUrl":null,"url":null,"abstract":"Elimination of the pain syndrome is still an urgent task in various fields of medicine. Therefore, the problem of finding new effective and safe analgesics remains today one of the most important. The research is aimed at comparing the central and peripheral analgesic activity of chemical mixture KOR 205 in an experiment in rats. Based on the results of the experimental work, indicators of the maximum possible effect (MVE%) have been determined. The KOR 205 compound has a more pronounced central analgesic effect, compared with peripheral analgesic activity.","PeriodicalId":30925,"journal":{"name":"Vestnik Volgogradskogo Gosudarstvennogo Universiteta Seria 11 Estestvennye Nauki","volume":"7 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":"{\"title\":\"Comparison of the Central and Peripheral Components of Action in Comprehensive Analgesic Activity of New Kappa-Agonist\",\"authors\":\"V. Batrakov, D. D. Shamshina, A. Ivanov\",\"doi\":\"10.15688/JVOLSU11.2018.1.5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Elimination of the pain syndrome is still an urgent task in various fields of medicine. Therefore, the problem of finding new effective and safe analgesics remains today one of the most important. The research is aimed at comparing the central and peripheral analgesic activity of chemical mixture KOR 205 in an experiment in rats. Based on the results of the experimental work, indicators of the maximum possible effect (MVE%) have been determined. The KOR 205 compound has a more pronounced central analgesic effect, compared with peripheral analgesic activity.\",\"PeriodicalId\":30925,\"journal\":{\"name\":\"Vestnik Volgogradskogo Gosudarstvennogo Universiteta Seria 11 Estestvennye Nauki\",\"volume\":\"7 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Vestnik Volgogradskogo Gosudarstvennogo Universiteta Seria 11 Estestvennye Nauki\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15688/JVOLSU11.2018.1.5\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Vestnik Volgogradskogo Gosudarstvennogo Universiteta Seria 11 Estestvennye Nauki","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15688/JVOLSU11.2018.1.5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Comparison of the Central and Peripheral Components of Action in Comprehensive Analgesic Activity of New Kappa-Agonist
Elimination of the pain syndrome is still an urgent task in various fields of medicine. Therefore, the problem of finding new effective and safe analgesics remains today one of the most important. The research is aimed at comparing the central and peripheral analgesic activity of chemical mixture KOR 205 in an experiment in rats. Based on the results of the experimental work, indicators of the maximum possible effect (MVE%) have been determined. The KOR 205 compound has a more pronounced central analgesic effect, compared with peripheral analgesic activity.
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