Sevgi Karabulut Uzunçakmak , Halil Özcan , Ebubekir Dirican , Ayşegül Tavacı Özçelik
{"title":"评估氧化应激增加的精神分裂症患者中 STC-1 和 STC-2 mRNA 的表达情况","authors":"Sevgi Karabulut Uzunçakmak , Halil Özcan , Ebubekir Dirican , Ayşegül Tavacı Özçelik","doi":"10.1016/j.amp.2023.02.005","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>Schizophrenia is a chronic psychiatric disorder characterized by cognitive impairment. Oxidative stress is associated with disease progression in patients with schizophrenia. Stanniocalcin (STC)-1 and STC-2 are two proteins commonly expressed in mammals belonging to the stanniocalcin family and they are involved in oxidative stress. The aim of this study is to investigate STC-1 and STC-2 mRNA expressions in schizophrenia patients with altered oxidative stress parameters.</div></div><div><h3>Methods</h3><div>For this purpose, 70 patients with schizophrenia and 40 healthy individuals were recruited for the study. Peripheral blood samples were obtained from all participants. Glutathione (GSH) activities, superoxide dismutase (SOD) activities, and malondialdehyde (MDA) levels were measured. STC-1 and STC-2 expressions were assessed by real-time polymerase chain reactions.</div></div><div><h3>Results</h3><div><span>SOD activity levels were lower in patients than in healthy individuals (p</span> <!-->=<!--> <!-->0.0309), while the patients’ MDA levels were higher (p<!--> <!-->=<!--> <!-->0.039). STC-1 and STC-2 expressions were lower in patients than in healthy individuals (p<!--> <!-->=<!--> <!-->0.1049 and p<!--> <!--><<!--> <!-->0.0001, respectively). Furthermore, these two genes had a positive correlation among the patients (r<!--> <!-->=<!--> <!-->0.435, p<!--> <!-->=<!--> <!-->0.0025). According to area under the curve (AUC) values, STC-2 (AUC<!--> <!-->=<!--> <!-->0.8332, p<!--> <!--><<!--> <!-->0.0001) had better diagnostic power than STC-1 (AUC<!--> <!-->=<!--> <!-->0.6167, p<!--> <!-->=<!--> <!-->0.1037).</div></div><div><h3>Conclusions</h3><div>The expression of stanniocalcins in schizophrenia was investigated here for the first time. Decreased STC-2 expression in patients with schizophrenia with increased oxidative stress parameters may guide the understanding of the pathophysiological mechanisms caused by oxidative stress, which may be increased in cognitive diseases such as schizophrenia, and it also has the potential to be a prognostic factor that can be used in the diagnosis of schizophrenia.</div></div>","PeriodicalId":7992,"journal":{"name":"Annales medico-psychologiques","volume":"182 9","pages":"Pages 785-790"},"PeriodicalIF":0.5000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluating STC-1 and STC-2 mRNA expressions in Schizophrenia patients with increased oxidative stress\",\"authors\":\"Sevgi Karabulut Uzunçakmak , Halil Özcan , Ebubekir Dirican , Ayşegül Tavacı Özçelik\",\"doi\":\"10.1016/j.amp.2023.02.005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><div>Schizophrenia is a chronic psychiatric disorder characterized by cognitive impairment. Oxidative stress is associated with disease progression in patients with schizophrenia. Stanniocalcin (STC)-1 and STC-2 are two proteins commonly expressed in mammals belonging to the stanniocalcin family and they are involved in oxidative stress. The aim of this study is to investigate STC-1 and STC-2 mRNA expressions in schizophrenia patients with altered oxidative stress parameters.</div></div><div><h3>Methods</h3><div>For this purpose, 70 patients with schizophrenia and 40 healthy individuals were recruited for the study. Peripheral blood samples were obtained from all participants. Glutathione (GSH) activities, superoxide dismutase (SOD) activities, and malondialdehyde (MDA) levels were measured. STC-1 and STC-2 expressions were assessed by real-time polymerase chain reactions.</div></div><div><h3>Results</h3><div><span>SOD activity levels were lower in patients than in healthy individuals (p</span> <!-->=<!--> <!-->0.0309), while the patients’ MDA levels were higher (p<!--> <!-->=<!--> <!-->0.039). STC-1 and STC-2 expressions were lower in patients than in healthy individuals (p<!--> <!-->=<!--> <!-->0.1049 and p<!--> <!--><<!--> <!-->0.0001, respectively). Furthermore, these two genes had a positive correlation among the patients (r<!--> <!-->=<!--> <!-->0.435, p<!--> <!-->=<!--> <!-->0.0025). According to area under the curve (AUC) values, STC-2 (AUC<!--> <!-->=<!--> <!-->0.8332, p<!--> <!--><<!--> <!-->0.0001) had better diagnostic power than STC-1 (AUC<!--> <!-->=<!--> <!-->0.6167, p<!--> <!-->=<!--> <!-->0.1037).</div></div><div><h3>Conclusions</h3><div>The expression of stanniocalcins in schizophrenia was investigated here for the first time. Decreased STC-2 expression in patients with schizophrenia with increased oxidative stress parameters may guide the understanding of the pathophysiological mechanisms caused by oxidative stress, which may be increased in cognitive diseases such as schizophrenia, and it also has the potential to be a prognostic factor that can be used in the diagnosis of schizophrenia.</div></div>\",\"PeriodicalId\":7992,\"journal\":{\"name\":\"Annales medico-psychologiques\",\"volume\":\"182 9\",\"pages\":\"Pages 785-790\"},\"PeriodicalIF\":0.5000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annales medico-psychologiques\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0003448723000653\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annales medico-psychologiques","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0003448723000653","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PSYCHIATRY","Score":null,"Total":0}
Evaluating STC-1 and STC-2 mRNA expressions in Schizophrenia patients with increased oxidative stress
Introduction
Schizophrenia is a chronic psychiatric disorder characterized by cognitive impairment. Oxidative stress is associated with disease progression in patients with schizophrenia. Stanniocalcin (STC)-1 and STC-2 are two proteins commonly expressed in mammals belonging to the stanniocalcin family and they are involved in oxidative stress. The aim of this study is to investigate STC-1 and STC-2 mRNA expressions in schizophrenia patients with altered oxidative stress parameters.
Methods
For this purpose, 70 patients with schizophrenia and 40 healthy individuals were recruited for the study. Peripheral blood samples were obtained from all participants. Glutathione (GSH) activities, superoxide dismutase (SOD) activities, and malondialdehyde (MDA) levels were measured. STC-1 and STC-2 expressions were assessed by real-time polymerase chain reactions.
Results
SOD activity levels were lower in patients than in healthy individuals (p = 0.0309), while the patients’ MDA levels were higher (p = 0.039). STC-1 and STC-2 expressions were lower in patients than in healthy individuals (p = 0.1049 and p < 0.0001, respectively). Furthermore, these two genes had a positive correlation among the patients (r = 0.435, p = 0.0025). According to area under the curve (AUC) values, STC-2 (AUC = 0.8332, p < 0.0001) had better diagnostic power than STC-1 (AUC = 0.6167, p = 0.1037).
Conclusions
The expression of stanniocalcins in schizophrenia was investigated here for the first time. Decreased STC-2 expression in patients with schizophrenia with increased oxidative stress parameters may guide the understanding of the pathophysiological mechanisms caused by oxidative stress, which may be increased in cognitive diseases such as schizophrenia, and it also has the potential to be a prognostic factor that can be used in the diagnosis of schizophrenia.
期刊介绍：
The Annales Médico-Psychologiques is a peer-reviewed medical journal covering the field of psychiatry. Articles are published in French or in English. The journal was established in 1843 and is published by Elsevier on behalf of the Société Médico-Psychologique.
The journal publishes 10 times a year original articles covering biological, genetic, psychological, forensic and cultural issues relevant to the diagnosis and treatment of mental illness, as well as peer reviewed articles that have been presented and discussed during meetings of the Société Médico-Psychologique.To report on the major currents of thought of contemporary psychiatry, and to publish clinical and biological research of international standard, these are the aims of the Annales Médico-Psychologiques.
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