一种叫做猴痘的致命疾病:一份非洲国家猴痘流行病例报告

Michael P. Okoh, Kenneth C., Nwachukwu
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引用次数: 2

摘要

猴痘病例继续上升,世界卫生组织(世卫组织)宣布其为国际关注的突发公共卫生事件。一种叫做猴痘的病毒引起这种疾病,它是人畜共患的。在非洲国家刚果民主共和国(DRC) 1981-1986年的流行病学监测中,该病为地方性疾病,仅记录了338例病例。以前,至少在非洲流行国家,90%的感染者是15岁左右的儿童。在非洲以外,99%的病例是男性,其中98%是男男性行为者,这意味着它是通过性行为传播的。拥挤的住所,恶劣的卫生条件,停止接种天花疫苗,以及其他与人际传播有关的因素。该病的症状包括病毒血症伴1-2天发热和出现病变前的淋巴结肿大。这个阶段的病人可能具有传染性。至于治疗方法,目前还没有已知的临床预防方法。聚合酶链反应(PCR)扩增用于特异性诊断,天花疫苗对该疾病有效。表1显示了来自非洲联盟成员国(AUMC)以及刚果共和国、喀麦隆和刚果民主共和国的病例,这些国家的累计发病率(CFR)分别很高(43.6%和4.1%)(见图2)。在这些流行国家,疫苗并不容易获得,因此,捐助国需要与研究人员和卫生官员合作,以确定南半球这些流行国家需要什么来扩大对这种疾病的应对。©2022全球研究与出版基金会。版权所有。
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A Virulent Disease Called Monkeypox: A Case Report ofCountries in Africa Where The Disease is Endemic
Cases of Monkeypox continue to rise and the World Health Organization (WHO), declared it a public health emergency of international concern (PHEIC). A virus called monkey pox causes the disease and it is zoonotic. The epidemiological surveillance from 1981-1986 in the Democratic Republic of Congo (DRC) a country in Africa were the disease is endemic, documented only 338 cases. Previously, 90% of the affected personswere children approximately 15 years of age at leastin the endemic countries in Africa. BeyondAfrica, 99% cases ofthe current outbreak were found in men and of those, 98% involved men who have sex with men implying it is being transmitted through sexual activities. Crowded living quarters, poor hygiene, discontinuation of the smallpox vaccination, amongst others wereimplicated in the human to human transmission. The symptoms of the disease includes, viremia with 1-2 days of fever and lymphadenopathy before lesions appear. Patients at this stage may be contagious. For treatments, there are no known clinically proventreatments for the disease. Polymerase chain reaction (PCR) amplification are used for specific diagnosisand smallpox vaccines are effective against the disease. Table 1 shows cases from Africa union member countries (AUMC), and Congo Republic, Cameroon and DRC, have a high cumulative frequency(CFR) of occurrence(43, 5.6 and 4.1%), respectively (see Fig 2). The vaccine is not readily available in these endemic countries thus, donors countries needs to collaborate with researchers and health officials to determine what these endemic countries in the global south requires towards enabling scale up in response to this disease. ©2022iGlobal Research and PublishingFoundation. All rights reserved.
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