精神分裂症患者生活质量和功能的预测因子

O. Căpăţînă, C. Pojoga, B. Savu, M. Fadgyas-Stănculete
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引用次数: 0

摘要

背景:为了追求康复,精神分裂症患者的生活质量(QoL)和一般功能是该疾病治疗中需要解决的里程碑。本研究的主要目的是检查生活质量、功能和症状与疾病临床特征之间的关系,并确定阴性症状的两个领域,倦怠/冷漠和表达减少,是否是精神分裂症患者生活质量和功能的预测因素。在本横断面研究中,87名被诊断为精神分裂症的患者完成了一套全面的工具评估:临床症状、病耻感、生活质量、功能、社会人口统计学和临床变量。采用多元回归分析检验预测变量对生活质量和功能的显著性。多元回归分析显示,内化污名、抑郁和兴奋是生活质量变异性的显著预测因子,经验缺陷和认知症状是功能变异性的显著预测因子。在精神分裂症患者中,功能和生活质量是两个相关但不同的概念。尽管它们密切相关,但它们有不同的预测因素。这些结果的临床意义是,这两种结构都应该被评估,并且改善它们的策略应该是不同的。
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Predictors of quality of life and functioning in schizophrenia
Background: In order to pursue recovery, Quality of life (QoL) and general functioning in patients with schizophrenia are milestones that need to be addressed in the treatment of the disease. The major aim of the present study was to examine the relationship between QoL, functionality and symptoms, and clinical characteristics of the disease, and to identify whether the two domains of negative symptoms, avolition/apathy and diminished expression, are predictive factors for the quality of life and functionality in patients diagnosed with schizophrenia. In the present cross-sectional study, 87 patients diagnosed with schizophrenia completed a thorough battery of instruments evaluating: clinical symptoms, stigma, QoL, functionality, socio-demographic and clinical variables. Multiple regression analyses were performed to test the significance of predictor variables for QoL and functionality. Multiple regression analyses revealed that internalized stigma, depression, and excitement were significant predictors for the variability of QoL, and experiential deficit and cognitive symptoms were significant predictors of the variability of functioning. In patients with schizophrenia, functioning and quality of life are two related but different constructs. Even though they are strongly associated, they have different predictive factors. The clinical implication of these results is that both of these constructs should be assessed and that the strategies for improving them should be different.
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来源期刊
Cognition, Brain, Behavior. An Interdisciplinary Journal
Cognition, Brain, Behavior. An Interdisciplinary Journal Psychology-Experimental and Cognitive Psychology
CiteScore
0.90
自引率
0.00%
发文量
14
期刊介绍: Cognition, Brain, Behavior. An Interdisciplinary Journal publishes contributions from all areas of cognitive science, focusing on disciplinary and interdisciplinary approaches to information processing and behavior analysis. We encourage contributions from the following domains: psychology, neuroscience, artificial intelligence, linguistics, ethology, anthropology and philosophy of mind. The journal covers empirical studies and theoretical reviews that expand our understanding of cognitive, neural, and behavioral mechanisms. Both fundamental and applied studies are welcomed. On occasions, special issues will be covering particular themes, under the editorship of invited experts.
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