Synthesis and anti-inflammatory activity of 2-amino-4,5-diphenyl-1-(substituted)-1H-pyrrole-3- carbonitrile derivatives

Pyrrole is privileged and active heterocycle with diverse pharmacological activities that specifically serve as a promising scaffold for antiinflammatory, antimalarial, antimicrobial, antiviral, antitubercular, and enzyme-inhibiting drugs. In an attempt to explore this scaffold, a series of 2- amino-4,5-diphenyl-1-(substituted)-1H-pyrrole-3-carbonitrilewere synthesized and screened for anti-inflammatory activity. The structures of synthesized novel compounds were characterized by 1H Nuclear Magnetic Resonance, Mass and Fourier Transfer Infrared spectroscopic data. All the compounds are screened for anti-inflammatory activity using the rat paw edema method. Among all, compound 1e exhibited more potent activity than the standard drug etoricoxib with the highest inhibition in paw edema at 3 h and 5 h.