绝经后骨质疏松症幽门螺杆菌感染妇女血清25-羟基维生素D和白细胞介素-1β水平

E. A. Maylyan, Elena S. Zhadan, A. Bagriy, O. A. Trunova, E. V. Prokhorov
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引用次数: 0

摘要

幽门螺杆菌病变的胃肠系统功能障碍不仅会显著减少钙(Ca)的吸收,还会减少维生素D和其他营养物质的吸收,而这些营养物质的摄入对骨骼的形成至关重要。幽门螺杆菌可以促进骨质疏松症的形成,并由于炎症过程的发展。炎症过程是上述骨病发病机制的重要组成部分。目的:探讨幽门螺杆菌CagA抗原抗体阳性绝经后OP患者血清25(OH)D和白细胞介素-1β水平的变化。材料和方法。该研究包括250名绝经后妇女,其指标(Me [Q1;Q3]) 62例[56例;68]年,绝经后持续时间为13年[7;20年。在所有患者的血清样本中测定25(OH)D含量和白细胞介素-1β (IL-1β)浓度。以及针对幽门螺杆菌CagA抗原的总抗体(IgA, IgM, IgG)。结果。在绝经后骨质疏松症的女性组中,幽门杆菌病的存在与血清中25-羟基维生素D水平下降14.8%相关(p=0.045)。绝经后妇女血清IL-1β值与幽门螺杆菌感染无关(p>0.05)。骨质疏松症妇女的25(OH)D和IL-1β值与幽门螺杆菌总抗体阳性呈负相关(rs=-0.25;p < 0.05)。结论。研究结果表明,绝经后骨质疏松症妇女体内维生素D的减少与幽门螺杆菌感染有关(p=0.045)。研究结果可用于绝经后妇女的诊断、治疗和预防措施。
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Serum levels of 25-hydroxyvitamin D and interleukin-1β in Helicobacter pylori-infected women with postmenopausal osteoporosis
Dysfunction of the gastrointestinal system in Helicobacter pylori lesions significantly reduces the absorption of not only calcium (Ca), but also vitamin D and other nutrients, the intake of which is critical for bone formation. H. pylory can contribute to the formation of osteoporosis and due to the development of the inflammatory process. The inflammatory process is an important component of the pathogenesis of the above bone disease. Objective: to study of the levels of 25(OH)D and interleukin-1β in blood serum in postmenopausal OP in women with a positive test for antibodies to the Helicobacter pylori CagA antigen. Materials and methods. The study included 250 postmenopausal women, whose indicators (Me [Q1; Q3]) were 62 [56; 68] years, and the duration of the postmenopausal period is 13 [7; 20] years. In all patients, the content of 25(OH)D and interleukin-1β (IL-1β) concentrations were determined in blood serum samples. And total antibodies (IgA, IgM, IgG) to the CagA antigen of the pathogen Helicobacter pylori. Results. In the female group with postmenopausal osteoporosis, the presence of helicobacteriosis is associated with a decrease in the level of 25-hydroxyvitamin D in the blood serum by 14.8% (p=0.045). Serum IL-1β values in postmenopausal women do not depend on H. pylori infection (p>0.05). A negative correlation was found between the values of 25(OH)D and IL-1β in women with osteoporosis and a positive test for total antibodies to H. pylori (rs=-0.25; p<0.05). Conclusion. The results of the study demonstrate that the decrease in vitamin D depends on the infection with Helicobacter pylori in women with postmenopausal osteoporosis (p=0.045). The results of the studies obtained can be used in the diagnostic and treatment-and-prophylactic measures for women in the postmenopausal period.
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