针刺放血配合耳穴按压治疗慢性荨麻疹的作用机制探讨

Boyuan Wang, Fangzi Shi, Yu Shi, Xuejun Zhang, Mingxin Sun, Yanjun Wang
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引用次数: 0

摘要

目的:探讨针刺出血联合耳压治疗慢性荨麻疹(CU)的疗效及治疗前后患者血清代谢物的差异。方法:招募6例符合要求的CU患者,采用荨麻疹活动评分(UAS)、瘙痒强度视觉模拟评分(VAS)、皮肤病生活质量指数(DLQI)评估不同时间点风团和瘙痒程度的变化。进一步采用液相色谱-质谱联用(LC/MS)和非靶向代谢组学分析分析治疗前后患者血清中的差异代谢物。结果:治疗后6例患者UAS、VAS、DLQI评分均较基线评分显著降低,差异均有统计学意义(P < 0.05)。结果还表明,刺血释血可下调患者血清溶血磷脂酰胆碱(LPC)水平。结论:穿刺放血配合耳穴按压可通过降低血清LPC,有效改善CU患者的生活质量,从而缓解CU患者的临床症状,提高治愈率。
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Exploration of the mechanism of action of stabbing and releasing blood combined with auricular acupressure in the treatment of chronic urticaria
Objectives: This study aimed to investigate the efficacy of stabbing and bleeding combined with auricular pressure in the treatment of chronic urticaria (CU) and the differential metabolites in the serum of patients before and after the treatment. Methods: Six patients with CU who met the requirements were recruited, and the changes in the degree of wind mass and itching at different time points were assessed using the Urticaria Activity Score (UAS), the Visual Analog Scale (VAS) score of pruritus intensity, and the Dermatologic Disease Quality of Life Index (DLQI). The differential metabolites in the serum of patients before and after the treatment were further analyzed using liquid chromatography-mass spectrometry duplex (LC/MS) and non-targeted metabolomics analysis. Results: Compared with baseline scores, UAS, VAS, and DLQI scores decreased significantly in six patients after the treatment, with statistically significant differences (P < 0.05). Results also suggested that stabbing and releasing blood for CU could down-regulate lysophosphatidylcholine (LPC) in patients' serum. Conclusion: The combination of piercing and bloodletting with auricular acupressure can effectively improve the life quality of CU patients through lowering LPC in serum, and thus alleviating the clinical symptoms and improving the cure rate of CU patients.
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