超多孔水凝胶颗粒在格列吡嗪快速崩解片中的作用

H. Chavda, Rupal D Patel, Ishan P Modhia, C. Patel
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引用次数: 3

摘要

背景:超多孔水凝胶(SPH)在较短的时间内迅速膨胀到平衡尺寸,并具有高度多孔结构。文献综述反映了SPHs及其复合物的制备,但其作为赋形剂在给药系统中的应用并没有得到很好的关注。目的:利用超多孔水凝胶颗粒(SPHPs)作为吸湿剂,研制格列吡嗪快速崩解片,缩短崩解时间。材料与方法:采用溶液聚合法制备了聚丙烯酰胺-共丙烯酸的SPH,并对其进行了表征。对制备的片剂进行了相关参数评价。采用32全因子设计和方差分析进行配方优化。结果:扫描电镜图清楚地证实了水凝胶的超孔结构。与其他潜在的超崩解剂相比,含有4%聚丙烯酰胺-共丙烯酸SPH的f4批超崩解剂具有极快的排芯效果和较短的崩解时间。与常规即刻释放上市产品相比,药物释放良好。结论:sphp可作为一种潜在的超崩解剂用于片剂处方。
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Role of superporous hydrogel particles as a superdisintegrant in fast disintegrating tablet of Glipizide
Background: Superporous hydrogel (SPH) swells very rapidly in a shorter period of time to an equilibrium size and contains highly porous structure. The literature survey reflects the preparation of SPHs and its composite, but its application as an excipient in a drug delivery system is not well focused. Aim: Efforts were made to develop fast disintegrating tablets of Glipizide using superporous hydrogel particles (SPHPs) as a wicking agent, which act as a superdisintegrant to decrease disintegration time. Materials and Methods: The SPH of poly (acrylamide-co-acrylic acid) was prepared by solution polymerization and characterized. Prepared tablets were evaluated for concerned parameters. Formulation optimization was carried out using 3 2 full factorial design and analysis of variance. Results: Scanning electron microscopy pictures clearly confirmed the superporous structure of hydrogel. Batch F 4 containing 4% w/w of SPH of poly (acrylamide-co-acrylic acid) as a superdisintegrant showed extremely fast wicking effect and lesser disintegration time compared with other potential superdisintegrants. Drug release was good compared with conventional immediate release marketed product. Conclusion: It can be concluded that SPHPs can be used as a potential superdisintegrant in tablet formulation.
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