固体UV交联PEGDA在生物领域的应用

2013 IEEE 26th International Conference on Micro Electro Mechanical Systems (MEMS 2013) : Taipei, Taiwan, 20-24 January 2013. IEEE International Conference on Micro Electro Mechanical Systems (26th : 2013 : Taipei, Taiwan) Pub Date : 2013-10-20 DOI:10.1109/MEMSYS.2013.6474277

David Castro, P. Ingram, R. Kodzius, D. Conchouso, E. Yoon, I. Foulds

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引用次数: 15

摘要

本文报道了固体UV交联聚(乙烯)-乙二醇-二丙烯酸酯(PEGDA)作为生物微流控器件的材料。我们通过两种不同的方法评估了PEGDA的生物相容性:1)通过检测细胞活力和在交联PEGDA表面的附着，用于细胞培养;2)通过检测交联PEGDA是否抑制芯片上PCR的聚合酶链反应(PCR)过程。通过这些研究发现了固化程度与细胞活力、附着以及PCR结果之间的相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Characterization of solid UV cross-linked PEGDA for biological applications

This paper reports on solid UV cross-linked Poly(ethylene)-glycol-diacrylate (PEGDA) as a material for microfluidic devices for biological applications. We have evaluated biocompatibility of PEGDA through two separate means: 1) by examining cell viability and attachment on cross-linked PEGDA surfaces for cell culture applications, and 2) by determining if cross-linked PEGDA inhibits the polymerase chain reaction (PCR) processes for on-chip PCR. Through these studies a correlation has been found between degree of curing and cell viability, attachment, as well as on PCR outcome.

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2013 IEEE 26th International Conference on Micro Electro Mechanical Systems (MEMS 2013) : Taipei, Taiwan, 20-24 January 2013. IEEE International Conference on Micro Electro Mechanical Systems (26th : 2013 : Taipei, Taiwan)

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