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2013 IEEE 26th International Conference on Micro Electro Mechanical Systems (MEMS 2013) : Taipei, Taiwan, 20-24 January 2013. IEEE International Conference on Micro Electro Mechanical Systems (26th : 2013 : Taipei, Taiwan)最新文献

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Characterization of solid UV cross-linked PEGDA for biological applications 固体UV交联PEGDA在生物领域的应用
David Castro, P. Ingram, R. Kodzius, D. Conchouso, E. Yoon, I. Foulds
This paper reports on solid UV cross-linked Poly(ethylene)-glycol-diacrylate (PEGDA) as a material for microfluidic devices for biological applications. We have evaluated biocompatibility of PEGDA through two separate means: 1) by examining cell viability and attachment on cross-linked PEGDA surfaces for cell culture applications, and 2) by determining if cross-linked PEGDA inhibits the polymerase chain reaction (PCR) processes for on-chip PCR. Through these studies a correlation has been found between degree of curing and cell viability, attachment, as well as on PCR outcome.
本文报道了固体UV交联聚(乙烯)-乙二醇-二丙烯酸酯(PEGDA)作为生物微流控器件的材料。我们通过两种不同的方法评估了PEGDA的生物相容性:1)通过检测细胞活力和在交联PEGDA表面的附着,用于细胞培养;2)通过检测交联PEGDA是否抑制芯片上PCR的聚合酶链反应(PCR)过程。通过这些研究发现了固化程度与细胞活力、附着以及PCR结果之间的相关性。
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引用次数: 15
Simultaneous ablation and injection by electrically-induced mono-dispersed bubble knife for biomedical applications 电致单分散气泡刀在生物医学上的同时消融和注射
H. Kuriki, Y. Yamanishi, S. Sakuma, S. Akagi, F. Arai
For the present study, simultaneous ablation and injection was successfully operated by using electrically-induced micro-bubble knife for biomedical applications. The novelty of the present techniques are (1) dispensing of micro-bubble can penetrate and make an ablation of a cytomembrane and (2) the reagent was successfully introduced to the interface of the bubble surface. This technique has advantages over the conventional injection technologies such as electroporation or ultrasound operation in terms of localization of injection and ability of transportation.
本研究成功地实现了电致微泡刀在生物医学领域的同时消融和注射。本技术的新颖之处在于:(1)微气泡的分配可以穿透和烧蚀细胞膜,(2)试剂被成功地引入到气泡表面的界面。与传统的注射技术如电穿孔或超声手术相比,该技术在注射的定位和运输能力方面具有优势。
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引用次数: 2
Neurospheroid array on a flexible substrate for cortical microstimulation 神经球阵列在皮质微刺激的柔性基质上
K. Okita, M. Kato‐Negishi, H. Onoe, S. Takeuchi
This paper describes a centimeter-sized flexible multi-electrode array (MEA) integrated with a neuronal spheroid (neurospheroid) array. The MEA has a number of neurospheroids and can be applied to extensively curved surfaces (e.g., brain). We demonstrated that MEA successfully activated neurons within a neurospheroid on the microelectrode array. In addition, the MEA was used to activate 2D culture of cortical cells through the neurospheroids. These results mark an important step toward achieving minimally-invasive cortical microstimulation via neurospheroid-based stimulating systems.
本文介绍了一种厘米级柔性多电极阵列(MEA)与神经元球体阵列(neurospheroid array)的集成。MEA具有许多神经球体,可以应用于广泛弯曲的表面(例如,大脑)。我们证明了MEA成功地激活了微电极阵列上的神经球内的神经元。此外,MEA通过神经球体激活皮层细胞的二维培养。这些结果标志着通过基于神经球的刺激系统实现微创皮质微刺激的重要一步。
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引用次数: 3
Nano actuator and “pull-back” nonlinearity 纳米致动器和“回拉”非线性
M. Ren, H. Lai, L. Isai, D. Kwong, A. Liu
This paper presents an optical force driven nano-machined actuator and the “pull-back” effect of a free-standing arc in an opto-mechanical ring resonator system. This nano-actuator obtains a maximal central displacement of 43.1 nm, with an actuation resolution of 0.28 nm, via tuning the wavelength of the control light at a fixed optical power of 2.8 mW. The “pull-back” effect occurs at the maximal displacement position, which is studied by the combination of experiments and simulation. Potential applications include bio-nano-motor, all-optical switches and opto-mechanical memories.
本文介绍了一种光力驱动的纳米机械致动器和光机械环形谐振器系统中独立弧的“回拉”效应。在2.8 mW的固定光功率下,通过调节控制光的波长,该纳米驱动器的最大中心位移为43.1 nm,驱动分辨率为0.28 nm。采用实验与仿真相结合的方法,对最大位移位置的“回拉”效应进行了研究。潜在的应用包括生物纳米马达、全光开关和光机械存储器。
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引用次数: 0
3D Parylene sheath probes for reliable, long-term neuroprosthetic recordings 3D聚对二甲苯鞘探针可靠,长期的神经假肢记录
J. Kuo, B. J. Kim, S. Hara, C. D. Lee, L. Yu, C. Gutierrez, T. Hoang, V. Pikov, E. Meng
Parylene C neural probes with a 3D sheath structure are introduced as a novel interface for long-term intracortical neural recording. 3D sheath structures were assembled from surface micromachined Parylene microchannels by thermoforming the thermoplastic around a solid microwire mold. Multiple Pt electrodes lined the interior and exterior of the sheath. Electrochemical characterization of the electrodes confirmed impedance values (50-250 KΩ at 1 kHz) suitable for neural recordings. A novel insertion approach was developed that temporarily stiffens the neural probes for surgical implantation and optimized in agarose brain tissue model. Sheath probes implanted into rat cortex recorded neural signals for four weeks. To achieve long-term, reliable recordings, the sheath structures will be coated with eluting neurotrophic factors to promote and attract neural ingrowth towards electrode sites.
介绍了一种具有三维鞘结构的聚对二甲苯神经探针,作为长期皮质内神经记录的新接口。通过在固体微丝模具周围热成型热塑性塑料,将表面微加工的聚苯二甲苯微通道组装成三维护套结构。多个Pt电极排列在护套的内部和外部。电极的电化学表征证实了适合神经记录的阻抗值(50-250 KΩ在1 kHz)。提出了一种新的神经探针暂时硬化的植入方法,并在琼脂糖脑组织模型中进行了优化。鞘探针植入大鼠皮层,记录了四周的神经信号。为了实现长期、可靠的记录,鞘结构将被涂上洗脱的神经营养因子,以促进和吸引神经向电极位置生长。
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引用次数: 7
Multi-material paper-disc devices for low cost biomedical diagnostics 用于低成本生物医学诊断的多材料纸盘装置
E. Vereshchagina, K. Bourke, L. Meehan, C. Dixit, D. M. Glade, J. Ducrée
In this work we demonstrate novel, low cost, hybrid, polymer-paper disc devices for carrying out biomedical tests in resource-poor settings. The system combines the advantages of two major effects - sample transport in a paper membrane by capillary force and active rotational flow control by centrifugal force. Capabilities of the paper disc system include but are not limited to spatiotemporal flow control, pre-storage of reagents and integrated colorimetric indicators all suitable for performing multiple-step bioassays.
在这项工作中,我们展示了在资源贫乏的环境中进行生物医学试验的新颖、低成本、混合、聚合物-纸光盘装置。该系统结合了两种主要效果的优点-通过毛细力在纸膜中传输样品和通过离心力主动旋转流动控制。纸盘系统的功能包括但不限于时空流量控制,试剂的预存储和集成比色指示器,所有这些都适合进行多步骤生物测定。
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引用次数: 8
Silicon nanowire and cantilever electromechanical switches with integrated piezoresistive transducers 硅纳米线和悬臂式机电开关集成压阻式换能器
Rui Yang, Tina He, C. Marcoux, P. Andreucci, L. Duraffourg, P. Feng
This digest paper reports experimental demonstration of a new type of nanoelectromechanical device, combining contact-mode nanomechanical switching with sensitive integrated strain gauges in suspended thin (sub-100nm) silicon nanowires (SiNWs). By measuring and modeling the interesting coupling effects between mechanical strain and electrical transport in highly piezoresistive (PZR) thin SiNWs at room temperature, we demonstrate that, in both doubly-clamped SiNWs and mechanically `cross' coupled cantilever-SiNW structures, contact-mode and tunneling switching with multiple repeatable cycles can be also simultaneously monitored and read out in the SiNW PZR transducers naturally embedded in the devices. Given the strong piezoresistive effects in thin SiNWs, this type of devices offer a new approach for monitoring contact-mode operations, and may prove valuable when the nanoscale contacts are not highly conductive, or degrading over time.
本文报道了一种新型纳米机电器件的实验演示,该器件将接触式纳米机械开关与灵敏的集成应变片结合在悬浮薄(亚100nm)硅纳米线(SiNWs)上。通过测量和模拟室温下高压阻(PZR)薄SiNW中机械应变和电输运之间有趣的耦合效应,我们证明,在双箝位SiNW和机械“交叉”耦合悬臂-SiNW结构中,具有多个可重复周期的接触模式和隧道开关也可以同时在嵌入器件中的SiNW PZR传感器中进行监测和读出。考虑到薄sinw中强大的压阻效应,这种类型的器件为监测接触模式操作提供了一种新方法,并且在纳米级接触不具有高导电性或随时间退化时可能被证明是有价值的。
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引用次数: 10
Simple and high-throughput fabrication of large-area and multilayer flexible polymer film structures for microfluidic organic light emitting diode 微流控有机发光二极管用大面积多层柔性聚合物薄膜结构的简单、高通量制备
M. Tsuwaki, J. Mizuno, T. Kasahara, T. Edura, S. Matsunami, J. Oshima, C. Adach, S. Shoji
A simple and high-throughput fabrication of large-area and multilayer polymer film structures was developed and applied for microfluidic organic light emitting diodes (OLED). We employed following three distinguished technologies, a) screen-printing technique for transparent electrodes, b) novel belt-transfer exposure technology for SU-8 microchannels, and c) heterogeneous low temperature bonding technology using self-assembly monolayer. A Liquid organic semiconductor as a liquid emitter was injected to each microchannel and photoluminescence and electroluminescence were obtained not only in a straight state, but also in a bending state. This large-area flexible microfluidic structure for OLED is applicable to nondisposable posters or displays which can be adopted around the curved surfaces of the various structures.
研究了一种简单、高通量的大面积多层聚合物薄膜结构制备方法,并将其应用于微流控有机发光二极管(OLED)中。我们采用了以下三种不同的技术,a)透明电极的丝网印刷技术,b) SU-8微通道的新型带转移曝光技术,以及c)使用自组装单层的非均质低温键合技术。在每个微通道中注入液态有机半导体作为液体发射器,在直线状态和弯曲状态下均可获得光致发光和电致发光。这种用于OLED的大面积柔性微流控结构适用于非一次性海报或显示器,可以在各种结构的曲面周围采用。
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引用次数: 1
Laterally actuated nanoelectromechanical relays with compliant, low resistance contact 具有柔顺、低电阻触点的横向驱动纳米机电继电器
M. Shavezipur, W. S. Lee, K. Harrison, J. Provine, S. Mitra, H. Wong, R. Howe
Laterally actuated nanoelectromechanical relays with compliant source-drain contacts are presented. The relay sidewalls are coated with a 30 nm-thick conductive layer of titanium nitride (TiN) deposited using atomic layer deposition (ALD). By hollowing the tip of the relay, a flexible sidewall is formed from the thin TiN that results in a larger contact area and therefore improves the contact properties of the relay. This modification improves the on-state resistance (RON) and also provides better stability over a larger number of switching cycles compared to a rigid contact. The results of life-time tests show that the contact resistance increases with the number of switching cycles possibly due to degradation of the contact material. However, flexible contacts show improved contact resistance stability under cyclic contact.
提出了具有柔性源漏触点的横向驱动纳米机电继电器。采用原子层沉积法(ALD)在继电器侧壁上涂覆30nm厚的氮化钛(TiN)导电层。通过将继电器的尖端挖空,由薄TiN形成柔性侧壁,从而产生更大的接触面积,从而改善继电器的接触特性。这种改进提高了导通电阻(RON),并且与刚性接触相比,在更大的开关周期内提供了更好的稳定性。寿命试验结果表明,接触电阻随着开关循环次数的增加而增加,这可能是由于接触材料的退化。然而,在循环接触下,柔性触点表现出更好的接触电阻稳定性。
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引用次数: 8
Microassembly of MEMS actuators and sensors via micro-masonry 微砌体微组装MEMS致动器和传感器
Y. Zhang, H. Keum, S. Kim
Micro-masonry is a microassembly technique that is based on transfer printing and direct bonding. This paper presents the assembly of MEMS mechanical sensors and actuators based on this micro-masonry technique. Microfabrication processes for retrievable MEMS components (e.g., combs, flexure beams, and metal pads) are developed. As manipulation tools, elastomeric microtipped stamps with switchable dry adhesion are also designed and fabricated to pick up and place those components. After the assembly, the components are permanently bonded together via rapid thermal annealing. The sensing and actuating capabilities of the assembled MEMS devices are characterized.
微砌筑是一种基于转移印刷和直接粘合的微组装技术。本文介绍了基于微砌体技术的MEMS机械传感器和执行器的装配。开发了可回收MEMS组件(例如,梳子,弯曲梁和金属垫)的微制造工艺。作为操作工具,具有可切换干附着力的弹性微尖端邮票也被设计和制造来拾取和放置这些组件。组装后,通过快速热退火将组件永久粘合在一起。对组装后的MEMS器件的传感和驱动能力进行了表征。
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引用次数: 3
期刊
2013 IEEE 26th International Conference on Micro Electro Mechanical Systems (MEMS 2013) : Taipei, Taiwan, 20-24 January 2013. IEEE International Conference on Micro Electro Mechanical Systems (26th : 2013 : Taipei, Taiwan)
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