超声辐照下有机催化剂4-二甲氨基吡啶(DMAP)一锅法合成新型吡啶[2,3-d]嘧啶衍生物

I. R. Parrey, A. A. Hashmi
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引用次数: 5

摘要

摘要以4-二甲氨基吡啶(DMAP)为新型有机催化剂,在N,N-二甲基甲酰胺(DMF)溶剂中,以取代芳醛、氰乙酰胺和6-氨基嘧啶为原料,采用Knoevenagel-Michal加成反应,在超声辐照下,一锅法合成了吡啶[2,3-d]嘧啶衍生物。结果表明,一系列芳香醛有效地制备了目标吡啶[2,3 -d]嘧啶衍生物,产率为81 ~ 93%,且给电子取代基/吸电子取代基对产物产率无明显影响。该工艺具有反应时间短、工艺环境友好、收率高、催化剂便宜易得等优点。所有合成的化合物都通过IR、1HNMR、13CNMR和质谱数据进行了表征。
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One-pot synthesis of new Pyrido [2,3-d] Pyrimidine derivatives under ultrasonic irradiation using organo catalyst 4-Dimethylaminopyridine (DMAP)
Abstract The one-pot synthesis of pyrido[2,3-d] pyrimidine derivatives has been reported via Knoevenagel-Michal addition pathways using substituted aromatic aldehydes, Cyanoacetamide and 6-aminouracil in N,N-dimethylformamide (DMF) solvent, with 4-dimethylaminopyridine (DMAP) as new organo catalyst catalyst under ultrasonic irradiation. The results showed that a series of aromatic aldehydes were effectively used to prepare the targeted pyrido [2, 3-d] pyrimidine derivatives with good to excellent yields (81-93 %) with no major effect on the yield of product by electron donating/withdrawing substituents. Short reaction time, environment friendly procedure, excellent yields, inexpensive and readily available catalyst are the advantages of this procedure. All synthesized compounds were characterized by IR, 1HNMR, 13CNMR and mass spectral data.
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