Therapeutic effects of thioctic acid combined with mecobalamin on peripheral neurotoxicity induced by radiochemotherapy in patients with breast cancer

Objective To investigate the efficacy of thioctic acid combined with mecobalamin in the treatment of peripheral neurotoxicity induced by radiochemotherapy in breast cancer patients. Methods A total of 94 breast cancer patients with peripheral neurotoxic adverse reactions induced by radiochemotherapy treated in the First Affiliated Hospital of Zhengzhou University from July 2017 to July 2018 were selected as research objects. And they were divided into control group and research group by random number table method. Patients in the research group (n=47) were treated with thioctic acid and mecobalamin, and patients in the control group (n=47) were treated with vitamin B12. The therapeutic effects of the two groups were analyzed and compared. Results The overall effective rate was 87.23% (41/47) in the research group, higher than the 51.06% (24/47) in the control group, and the difference was statistically significant (χ2=5.068, P<0.05). Conclusions Thioctic acid combined with mecobalamin has better therapeutic effects than vitamin B12 in the treatment of peripheral neurotoxicity caused by radiochemotherapy in breast cancer patients. Key words: Thioctic acid; Mecobalamin; Peripheral neurotoxicity