Scientific validation and formulation of three Indian Folklore medicinal plants

Aims

The present study was aimed to study the in vitro antioxidant property by DPPH, superoxide, and hydroxyl radical scavenging assays, in vivo hepatoprotective activity by CCl₄ induced hepatotoxicity in albino rats, formulation of polyherbal hepatoprotective tablets containing equal quantities of methanolic extract of roots of Begonia laciniata Roxb., whole plant of Cuscuta epithymum (L.) L and whole plant of Dendrobium ovatum (L.) Kraenzl., which were used traditionally in Chittoor and Khammam districts of Andhra Pradesh, India.

Methods

Formulation was developed by direct compression method using super tab-11SD, primojel, talc and magnesium stearate as excipients and then subjected to evaluation of precompression and post compression parameters.

Results and conclusion

All the selected plants showed dose dependant antioxidant property, highest at 360 μg dose and significant dose dependant hepatoprotective activity, highest at a dose of 400 mg/kg b.w compared to standard drug silymarin, the histopathological studies also confirmed protective effects of extracts against CCl4-induced liver injuries. The observations from formulation support the ideal properties of compressed tablets and its feasibility for large-scale commercial production.