一位63岁男性,表现不典型的病毒性脑膜炎

Allen M. Quirit
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摘要

病毒性脑膜炎通常表现为头痛,发烧和脑膜刺激的迹象在免疫正常的成年人。通常表现为颈部僵硬和意识的深刻改变。如果没有分子技术,病毒性脑膜炎可能仍然是一个诊断谜。快速分子分析是诊断病毒等难以生长的病原体的巨大进步,因此可以成为抗菌药物管理的重要工具。我们报告一例b.e.患者,63岁男性,工程师,以发烧为主诉,间歇性发烧4天。没有其他相关症状,如头痛,模糊和身体虚弱。住院3天后,仍有间歇性发热,无相关症状。入院后数日,患者突然出现全身无力和畏光。所有实验室检查如CT扫描,电解质和全血细胞计数显示正常。生命体征及体格检查无明显异常。因畏光、头痛等典型脑膜炎症状,于住院第6天行腰椎穿刺。根据临床表现和脑脊液分析,诊断为病毒性脑膜炎。CSF分析后要求Phadebac,未分离到微生物。患者给予阿昔洛韦、类固醇和甘露醇治疗。神经学家和传染病专家根据实验室的结论性结果将该病例列为病毒性脑膜炎。
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A 63 Year Old Male with Atypical Presentation of Viral Meningitis
Viral meningitis usually present with headache, fever and signs of meningeal irritation in immunocompetent adult. Nuchal rigidity and profound alteration of consciousness usually present. Viral meningitis may remain a diagnostic enigma without molecular techniques. Rapid molecular assays are the great advancement for the diagnosis of difficult to grow pathogens such as viruses and thus can become a big tool in antimicrobial stewardship. We presented a case of B.E a 63 years old male, worked as engineer came in with chief complaint of fever, intermittent for four days. No other associated symptoms noted such as headache, blurring and body weakness. After 3 days of hospitalization, still with intermittent fever without any associated complaints. On succeeding days of admission, patient developed sudden generalized body weakness and photophobia. All laboratory exam such as CT scan, electrolytes and complete blood count revealed normal. Vital signs and Physical examination were unremarkable. Lumbar puncture was done on 6th hospital day due to classic symptoms of meningitis such as photophobia and headache. The diagnosis was concluded as viral meningitis based on clinical presentation and CSF fluid analysis. Phadebac was requested after CSF analysis and no microorganisms were isolated. Patient was managed accordingly with acyclovir, steroids and mannitol. The neurologist and infectious disease specialist signed out the case as viral meningitis with conclusive laboratory result.
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