SYNTHESIS, CHARACTERIZATION AND ANTI-TUBERCULAR ACTIVITY OF 1, 3- THIAZINE DERIVATIVES

Due to their potent biological activity, heterocyclic compounds have been used extensively in pharmacological research.Researchers' interest has been drawn to the heterocyclic molecule thiazine, which has four carbon atoms, one nitrogenatom, and one sulphur atom. It has interesting pharmacological properties. In the present work, a series of new thiazinederivatives were synthesized from substituted chalcone derivatives. Starting material was acetophenone derivatives. Thestructures of these compounds were confirmed by IR, NMR, Mass and elemental analysis. The synthesized compounds(IVa-IVe) were screened for anti-tuberculosis activity against Mycobacterium tuberculosis and the results show that some ofthese derivatives possess good activity against Mycobacterium tuberculosis.