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Isolation and Characterization of Rhizobacteria from Soil and Its Efficiency as Plant Growth- Promoting Microbes 从土壤中分离和鉴定根瘤菌及其作为植物生长促进微生物的效率
Pub Date : 2024-04-02 DOI: 10.55218/jasr.2024150306
Monal Ingawale, Sandhya Patil, Mukesh Tiwary, Sayali Mane, Mohan Waman
Rhizosphere is the soil environment where the plant root is available and is a zone of maximum microbial activity resulting in a confined nutrient pool in which essential macro-and micronutrients are extracted. The microbial population present in the rhizosphere is relatively different from that of its surroundings due to the presence of root exudates that function as a source of nutrients for microbial growth. Among all these interactions, those resulting in symbiotic and non-symbiotic nitrogen fixation are considerably important. In recent years, the use of bacteria (rhizobacteria) to promote plant growth has increased in several regions of the world and has acquired relevant importance in developing countries that are the producers of raw materials for food.In the present study Rhizobacteria was isolated from the soil and the production of IAA and phosphate solubilisatrion was studied. The effect of PGPR was done on Mat seeds (matki) and black-eyed peaseeds (chawali) on the growth of plants.
根圈是植物根部所在的土壤环境,是微生物活动最活跃的区域,形成了一个封闭的养分池,可提取必需的宏量和微量营养元素。由于根部渗出物是微生物生长的养分来源,因此根瘤层中的微生物种群与周围环境中的微生物种群相对不同。在所有这些相互作用中,导致共生和非共生固氮的作用相当重要。近年来,利用细菌(根瘤菌)促进植物生长的情况在世界多个地区有所增加,在作为食品原材料生产国的发展中国家也具有重要意义。本研究从土壤中分离出根瘤菌,研究了根瘤菌产生 IAA 和磷酸盐溶解剂的情况,并研究了 PGPR 对马铃薯种子(matki)和黑眼豆荚(chawali)植物生长的影响。
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引用次数: 0
Contribution of Unani Physicians in Tashrīḥ al-Raḥim (Anatomy of the Uterus): A Systematic Review 尤那尼医生对 Tashrīḥ al-Raḥim(子宫解剖学)的贡献:系统回顾
Pub Date : 2024-04-02 DOI: 10.55218/jasr.2024150302
Samreen Khan, N. A. Ansari, M. A. B. Quadri, Abdul Malik, Md I Khan
The Unani System of Medicine pioneered in Greece and was developed by Arabs into an elaborate medical science based on the frame work of the teaching of Buqrāṭ (Hippocrates) and Jālīnūs (Galen). Since that time Unani Medicine has been known as Grek-o-Arab Medicine. Tashrīḥ-al-badan (Anatomy) is one of the oldest basic sciences. In Alexandria (1st recorded school of anatomy) where the renowned anatomical teachers Herophilus and Erasistratus dissected the human body and described many of its structures. Herophilus (335-280 B.C.) and Aristotle (384-322 B.C.) were the earliest who emphasized about the knowledge of human anatomy and laid the foundation of the subject, Tashrīḥ-al-badan (Anatomy). Galen's description of the "one-sex model" depicted the female and male reproductive organs as homologous anatomical structures, with differences only in location, size, and complexity. Woman is given prime importance in our classics since ancient times as it is the root cause for progeny. This paper enlightens the admirable work done by Unani physicians, who compiled their observations and research work about Tashrīḥ al-Raḥim (anatomy of uterus) which is present in our ancient Unani literature. To compile the contribution of Unani physicians in anatomy of uterus we search and collect the material from Unani classical reference books Al-Qānūn fi’l Ṭibb, Kāmil al-Ṣanā‘a al-Ṭibbiyya, Al-Manṣūrī fi’l Ṭibb, Modern books, Journal, Research Paper, and Online resources etc.
乌纳尼医学体系开创于希腊,后由阿拉伯人根据 Buqrāṭ(希波克拉底)和 Jālīnūs(盖伦)的教学框架发展成为一门精细的医学科学。从那时起,尤那尼医学就被称为 "希腊-阿拉伯医学"。Tashrīḥ-al-badan(解剖学)是最古老的基础科学之一。在亚历山大(第一所有记载的解剖学校),著名的解剖学教师希罗菲勒斯和伊拉西特拉图解剖了人体,并描述了人体的许多结构。希罗菲勒斯(公元前 335-280 年)和亚里士多德(公元前 384-322 年)是最早强调人体解剖知识的人,他们奠定了 Tashrīḥ-al-badan(解剖学)这一学科的基础。盖伦描述的 "单性模型 "将女性和男性的生殖器官描述为同源的解剖结构,区别仅在于位置、大小和复杂程度。自古以来,女性在我们的经典中都占据着重要地位,因为它是孕育后代的根本原因。本文介绍了乌那尼医生所做的令人钦佩的工作,他们汇编了自己对 Tashrīḥ al-Raḥim(子宫解剖学)的观察和研究成果,这些都存在于我们古老的乌那尼文献中。为了汇编尤那尼医生在子宫解剖学方面的贡献,我们从尤那尼经典参考书《Al-Qānūn fi'l Ṭibb 》、《Kāmil al-Ṣanā'a al-Ṭibbiyya》、《Al-Manṣūrī fi'l Ṭibb 》、现代书籍、期刊、研究论文和在线资源等中搜索和收集资料。
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引用次数: 0
Evaluation of Neuroprotective effect of Bioactive compounds of Mucuna monosperma in PD lines of Drosophila melanogaster 评估单叶木瓜生物活性化合物对黑腹果蝇PD品系的神经保护作用
Pub Date : 2024-04-02 DOI: 10.55218/jasr.2024150304
S. S, Kiran Kumar K V, Ashadevi J.S
Parkinson's Disease (PD) is a progressive neurodegenerative disorder that affects the nervous system. Oxidative stress (OS) plays an important role in the degeneration of dopaminergic neurons in PD. Ongoing research is focused on discovering new plant sources and developing alternative methods of production to meet the increasing demand for the treatment of Parkinson's disease. Ethnopharmacognosy plays a vital role in bridging traditional knowledge with modern science, and the screening of natural compounds from edible plants is a valuable approach to discovering new therapeutic agents. Hence, the exploration of plants and their bioactive compounds for drug development is an ongoing and promising field. This paper embodies results on neuroprotective property of Mucuna monosperma (MM), two major bioactive compounds namely l-3,4-dihydroxyphenylalanine (L-DOPA) and Ursolic acid were identified and isolated by Prep-HPLC and Column chromatography respectively. Further, quantified the isolated compounds by HPLC. The antioxidant property of crude, L-Dopa and Ursolic acid were scrutinized and verified through DPPH and Nitric oxide scavenging assay.  To evaluate the neuroprotective property and anti-ageing effect of bioactive compounds, negative geotaxis, courtship behavior and longevity studies were made in Transgenic PD line of Drosophila melanogaster against oxidative stress status.  Result reveals that the climbing ability, courtship behaviors and longevity were significantly increased in PD lines (Elva/SNCA-A30P) under stress conditions. Further it was noticed that synergetic effects of Ursolic acid along with L-Dopa showed excellent result.
帕金森病(PD)是一种影响神经系统的进行性神经退行性疾病。氧化应激(OS)在帕金森病多巴胺能神经元的退化过程中起着重要作用。目前的研究重点是发现新的植物来源和开发替代生产方法,以满足日益增长的帕金森病治疗需求。民族药理学在连接传统知识与现代科学方面发挥着重要作用,而从可食用植物中筛选天然化合物是发现新治疗药物的重要方法。因此,探索植物及其生物活性化合物用于药物开发是一个持续且前景广阔的领域。本文介绍了有关单叶木瓜(MM)神经保护特性的研究结果,通过预高效液相色谱法和柱层析法分别鉴定和分离了两种主要的生物活性化合物,即 l-3,4-二羟基苯丙氨酸(L-DOPA)和熊果酸。此外,还通过 HPLC 对分离出的化合物进行了定量。通过 DPPH 和一氧化氮清除试验,对粗品、左旋多巴和熊果酸的抗氧化性进行了仔细研究和验证。 为了评估生物活性化合物的神经保护特性和抗衰老作用,研究人员在黑腹果蝇转基因 PD 品系中进行了针对氧化应激状态的负趋向性、求偶行为和寿命研究。 结果表明,在应激条件下,黑腹果蝇转基因品系(Elva/SNCA-A30P)的爬行能力、求偶行为和寿命都明显增加。此外,研究还发现熊果酸与左旋多巴的协同作用效果极佳。
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引用次数: 0
A Review on Coronary Stents: With Polymers and without Polymers 冠状动脉支架综述:含聚合物和不含聚合物的冠状动脉支架
Pub Date : 2024-04-02 DOI: 10.55218/jasr.2024150301
Geetha Karra, S. Anila, MS Bindhu
Polymers have many uses in cardiology, such as coating matrices for drug-eluting stents and stent platforms (scaffolds) during coronary vascular intervention. Current research focuses on biodegradable polymers rather than permanent polymers. Their use may help to lessen undesirable events such as in-stent restenosis, late stent-thrombosis, and hypersensitivity reactions since they disintegrate once their purpose is served. This paper discusses factors affecting tissue and blood cell functions that should be taken into account when assessing the biocompatibility of stent polymers to improve physiologically suitable 3 Polymers are frequently used in cardiology, particularly in coronary vascular intervention, as coating matrices for drug-eluting stents and stent platforms (scaffolds). In addition to permanent polymers, biodegradable polymers are the subject of current study. Since they break down once their function is completed, using them may help prevent unfavorable outcomes such as in-stent restenosis, late stent thrombosis, and hypersensitivity reactions. This review discusses aspects of blood cell and tissue operations that should be taken into account to evaluate the biological compatibility of stent polymer compounds to improve physiologically relevant features after examining recent literature on polymers used in applications related to cardiology. The shape, difference, motion, and future of vascular cells can all be significantly influenced by the characteristics of the supporting material that they are grown. Lastly, a summary of techniques for measuring these parameters in a physiological setting will be provided.
聚合物在心脏病学中有许多用途,如药物洗脱支架的涂层基质和冠状动脉血管介入治疗中的支架平台(支架)。目前的研究重点是生物可降解聚合物,而不是永久性聚合物。使用这些聚合物有助于减少支架内再狭窄、支架晚期血栓形成和超敏反应等不良事件,因为一旦达到目的,它们就会分解。本文讨论了在评估支架聚合物的生物相容性时应考虑的影响组织和血细胞功能的因素,以改善生理上合适的 3 聚合物作为药物洗脱支架和支架平台(支架)的涂层基质,经常用于心脏病学,尤其是冠状动脉血管介入治疗。除了永久性聚合物外,生物可降解聚合物也是当前研究的主题。由于生物可降解聚合物的功能一旦完成就会分解,因此使用生物可降解聚合物有助于防止支架内再狭窄、支架晚期血栓形成和超敏反应等不良后果。本综述在研究了近期与心脏病学相关的聚合物应用文献后,讨论了在评估支架聚合物化合物的生物相容性时应考虑的血细胞和组织操作方面的问题,以改善与生理相关的特征。血管细胞的形状、差异、运动和未来都会受到其生长支撑材料特性的显著影响。最后,将总结在生理环境中测量这些参数的技术。
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引用次数: 0
Formulation and Evaluation of Polyherbal Antidiabetic Capsules 多草药抗糖尿病胶囊的配制与评估
Pub Date : 2024-04-02 DOI: 10.55218/jasr.2024150305
Geetha Karra, Vudutha Bhavani, RS Kiran, T. Rao
This research aims to create and assess polyherbal anti-diabetic capsules using medicinal plants with anti-diabetic properties. The formulation process involves carefully choosing botanical extracts with antidiabetic properties, verifying their bioactive compounds, and blending them to form a polyherbal blend with maximum antidiabetic potential while ensuring safety.Micro Crystalline Cellulose is used in encapsulating a polyherbal mix for stability, release, and patient convenience. Capsule dosage form is recommended for improved treatment adherence. Efficiency is assessed through in vitro studies on enzymes involved in glucose metabolism and their inhibitory effect.The results of this study offer a viable natural option for managing diabetes by providing important insights into the composition of polyherbal antidiabetic capsules. Several botanical extracts with complimentary modes of action have the potential to be combined, offering a comprehensive strategy to address the complex nature of diabetes mellitus. Nevertheless, more clinical studies including diabetes patients are necessary to confirm the long-term advantages, safety, and effectiveness of the capsules. The creation of polyherbal antidiabetic capsules may present novel approaches to the management of diabetes, enhancing glycaemic control and elevating the standard of living for those with the condition.
本研究旨在利用具有抗糖尿病特性的药用植物,制作和评估多草药抗糖尿病胶囊。配制过程包括精心选择具有抗糖尿病特性的植物提取物,验证其生物活性化合物,并将其混合形成具有最大抗糖尿病潜力的多草药混合物,同时确保安全。建议采用胶囊剂型,以提高治疗的依从性。这项研究的结果为多草药抗糖尿病胶囊的成分提供了重要的见解,为控制糖尿病提供了一种可行的天然选择。几种具有互补作用模式的植物提取物有可能结合在一起,为解决糖尿病的复杂性提供一种综合策略。不过,有必要对糖尿病患者进行更多的临床研究,以确认胶囊的长期优势、安全性和有效性。多草药抗糖尿病胶囊的问世可能会为糖尿病的治疗提供新的方法,加强血糖控制,提高糖尿病患者的生活水平。
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引用次数: 0
SYNTHESIS, CHARACTERIZATION AND BILOGICAL EVALUATION OF 2,4,6- TRISUBSTITUTED 1,3,5-TRIAZINE DERIVATIVES 2,4,6- 三取代 1,3,5- 三嗪衍生物的合成、表征和生物评估
Pub Date : 2023-12-30 DOI: 10.55218/jasr.2023141102
V. P. Gilava, P. K. Patel
A new series of 2,4,6-trisubstituted 1,3,5-triazine derivatives were synthesized from 2,4,6-trichloro-1,3,5-triazine(Cyanuric Chloride) and 4-(4-aminophenyl)morpholin-3-one via regioselective reaction followed by reflux with substituted aryl amine in the presence of catalytic amount of triethyl amine. All the synthesized compounds were characterized by IR, 1HNMR, Mass and Elemental Analysis. The newly synthesized compounds were also screened for their in vitro antimicrobial activity against standard drugs and some of them found to be remarkably active.
在三乙胺催化下,以 2,4,6-三氯-1,3,5-三嗪(氰尿酰氯)和 4-(4-氨基苯基)吗啉-3-酮为原料,通过与取代的芳基胺进行区域选择性反应和回流,合成了一系列新的 2,4,6-三取代的 1,3,5-三嗪衍生物。所有合成化合物均通过红外光谱、1HNMR、质量和元素分析进行了表征。此外,还对新合成的化合物进行了体外抗菌活性筛选,发现其中一些化合物具有显著的抗菌活性。
{"title":"SYNTHESIS, CHARACTERIZATION AND BILOGICAL EVALUATION OF 2,4,6- TRISUBSTITUTED 1,3,5-TRIAZINE DERIVATIVES","authors":"V. P. Gilava, P. K. Patel","doi":"10.55218/jasr.2023141102","DOIUrl":"https://doi.org/10.55218/jasr.2023141102","url":null,"abstract":"A new series of 2,4,6-trisubstituted 1,3,5-triazine derivatives were synthesized from 2,4,6-trichloro-1,3,5-triazine(Cyanuric Chloride) and 4-(4-aminophenyl)morpholin-3-one via regioselective reaction followed by reflux with substituted aryl amine in the presence of catalytic amount of triethyl amine. All the synthesized compounds were characterized by IR, 1HNMR, Mass and Elemental Analysis. The newly synthesized compounds were also screened for their in vitro antimicrobial activity against standard drugs and some of them found to be remarkably active.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":" 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139139613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A COMPARATIVE PHARMACEUTICO - ANALYTICAL STUDY OF ASHTASHATHO ARISHTA ACCORDING TO USHNAKALA AND SHEETAKALA 根据 ushnakala 和 sheetakala 对 ashtashatho arishta 进行的比较药学分析研究
Pub Date : 2023-12-30 DOI: 10.55218/jasr.2023141105
Bhadhra V, Asha P N
Sandhana Kalpana is regarded as valuable therapeutics due to their efficacy and desirable features. Ashtashathoarishta is one among them explained in Ayurvedic classics. It is an arishta preparation explained by Acharya Charaka in the treatment of Shopha with a specified kala for sandhanaprakriya. The time required for fermentation is said to vary according to ushnakala (7 days) & sheethakala (14 days). The main ingredients of Ashtashathoarishta include Kashmarya, Haritaki, Vibhitaki, Amalaki, Maricha, Pippali, Drakshaphala and Purana guda. Ashtashathoarishta is kept for Sandhana in madhulipthabhajana although most Asava-arishtas are kept in gritha-lipthabhajana. Generally, dhatakipushpa acts as sandhanadravya but in case of Ashtashathoarishta as Acharaya Charaka has not mentioned about any sandhanadravyas separately, Drakshaphala, purana guda and madhu serves its function. Objective of this research was to compare the Pharmaceuticoanalytical study of AshtashathoArishta prepared in ushna kala and sheeta kala. Total 12 samples (three samples of each withsandhana kala of 7 days and 14 days in both ushna and sheeta kala) will be prepared. Samples were tested forpharmaceutical and physico chemical parameters. On the basis of organoleptic study and analytical values of the samples, a comparison is done. All the samples of Ashtashathoarishta were analytically compared. The fermentation process is faster in ushna kala than in sheeta kala. The properties of the samples also vary in both the kalas. This revealed that the kala has a major role in the fermentation process.
Sandhana Kalpana 因其功效和可取之处而被视为珍贵的疗法。Ashtashathoarishta 是阿育吠陀经典中的一种。它是阿查里亚-查拉卡(Acharya Charaka)在治疗 Shopha 时使用的一种 arishta 制剂,带有用于 sandhanaprakriya 的特定 kala。据说发酵所需的时间根据 ushnakala(7 天)和 sheethakala(14 天)的不同而不同。Ashtashathoarishta 的主要成分包括 Kashmarya、Haritaki、Vibhitaki、Amalaki、Maricha、Pippali、Drakshaphala 和 Purana guda。Ashtashathoarishta 被保存在 madhulipthabhajana 的 Sandhana 中,尽管大多数 Asava-arishtas 被保存在 gritha-lipthabhajana 中。一般来说,dhatakipushpa 起着 sandhanadravya 的作用,但就 Ashtashathoarishta 而言,由于 Acharaya Charaka 没有单独提到任何 sandhanadravyas,因此 Drakshaphala、purana guda 和 madhu 起着它的作用。本研究的目的是比较用 ushna kala 和 sheeta kala 制备的 AshtashathoArishta 的药理分析研究。总共将制备 12 个样品(在 ushna kala 和 sheeta kala 中各制备 3 个 7 天和 14 天的 sandhana kala 样品)。对样品进行药物和理化参数测试。根据样品的感官研究和分析值进行比较。对所有 Ashtashathoarishta 样品进行了分析比较。ushna kala 的发酵过程比 sheeta kala 快。两种卡拉的样品特性也各不相同。这表明卡拉在发酵过程中起着重要作用。
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引用次数: 0
WATER QUALITY ANALYSIS USING PHYSIOCHEMICAL PARAMETERS AND GEOSPATIAL DISTRIBUTION FOR FIVE SELECTED LAKES OF BHANDARA DISTRICT IN 利用理化参数和地理空间分布对印度班达拉地区五个选定湖泊进行水质分析
Pub Date : 2023-12-30 DOI: 10.55218/jasr.2023141104
Laxman P. Nagpurkar, Shubham C. Ambilkar, Vikas P. Bawankule
In order to understand the water quality of five selected fresh water lakes of Bhandara district, Maharashtra (India), physicochemical characteristics viz. water temperature, pH, electrical conductivity (EC), total dissolved solids (TDS), total hardness (TH), dissolved oxygen (DO),chemical oxygen demand (COD) were investigated. Samples were collected from fifteen different points of five lakes (three samples from each lake) during the pre-monsoon and post-monsoon season. To understand the spatial distribution of physiochemical parameters with the help of Geospatial Technology, we used the Inverse Distance Weighted (IDW) interpolation method. The consequences of study were validated by comparing with World Health Organization (WHO) and Bureau of Indian Standard (BIS) criteria for drinking water. All physicochemical parameters were recorded more or less similar ecological status under permissible limit during the study period. This study also reveals that, water quality parameters were found apparently lower during post-monsoon season, which could have been due to dilution of water in post-monsoon season.
为了了解印度马哈拉施特拉邦班达拉地区五个选定淡水湖的水质情况,对水温、pH 值、电导率 (EC)、溶解固体总量 (TDS)、总硬度 (TH)、溶解氧 (DO) 和化学需氧量 (COD) 等物理化学特征进行了调查。在季风前和季风后季节,从五个湖泊的 15 个不同点采集了样本(每个湖泊采集三个样本)。为了借助地理空间技术了解理化参数的空间分布,我们使用了反距离加权(IDW)插值法。研究结果与世界卫生组织(WHO)和印度标准局(BIS)的饮用水标准进行了对比验证。在研究期间,所有理化参数都或多或少地处于允许限度内的生态状态。这项研究还表明,季风后季节的水质参数明显较低,这可能是由于季风后季节的水被稀释所致。
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引用次数: 0
The adsorbent GREEN SYNTHESIS OF CHARCOLATED ADSORBENT DERIVED FROM PUNICA GRANTANUM STEMS AND ITS APPLICATION IN DYE REMOVAL OF METHYL ORANGE, CHROMOSEINT BLUE, ERIOCHROME BLACK -T AND MALACHITE GREEN 从罂粟根茎中提取的有色吸附剂的绿色合成及其在去除甲基橙、胭脂虫蓝、ERIOCHROME BLACK -T 和 MALACHITE GREEN 的染料中的应用
Pub Date : 2023-12-30 DOI: 10.55218/jasr.2023141103
Harshal S. Kharde, Champa Maurya, H. Aher
The existence of dye molecules prolonged in water effluents of special concern is removed through green synthesized Punica Grantanum stem adsorbent (PGSA) embedded in removal of dye as methyl orange, Chromoseint blue, Eriochrome black-T, malachite green. Charcolated adsorbent was subjected to characterization as, SEM, TEM and FTIR. PGSA was employed in parametric study of effect of pH, effect of adsorbent dose on dye removal, effect of adsorbent on concentration of dye and effect of temperature on dye removal. Maximum removal of dye was observed at basic pH 8, as adsorbent dose of 0.5g give maximum removal of dye molecules. Maximum dye concentration of 1×10-5M show best result for dye removal and 30°C temperature was effective for various dyes giving removal efficiency. Experimental work was conducted on UV-Visible spectrophotometer with time gradient of 15 minutes time interval up to 180 minutes. So, this study revels use of charcolated adsorbent of Punica Grantanum stem is effective for dye removal purpose.
在去除甲基橙、Chromoseint 蓝、Eriochrome 黑-T 和孔雀石绿等染料时,通过嵌入绿色合成的石榴茎吸附剂(PGSA),可去除特别令人担忧的废水中长期存在的染料分子。对炭化吸附剂进行了表征,如 SEM、TEM 和 FTIR。利用 PGSA 对 pH 值的影响、吸附剂剂量对染料去除的影响、吸附剂对染料浓度的影响以及温度对染料去除的影响进行了参数研究。在碱性 pH 值为 8 时,染料去除率最高,吸附剂剂量为 0.5 克时,染料分子去除率最高。最大染料浓度为 1×10-5M 时,染料去除效果最好;温度为 30°C 时,各种染料的去除效率都很高。实验工作在紫外-可见分光光度计上进行,时间梯度为 15 分钟至 180 分钟。因此,这项研究表明,使用石榴茎炭化吸附剂能有效去除染料。
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引用次数: 0
A STUDY TO ANALYSE THE ANTIMICROBIAL ACTIVITY OF KUSHTA AMRUTHASANGADI AVACHURNANA AND ITS MODIFIED MALAHARA FORM 分析 Kushta amruthasangadi avachurnana 及其改良马拉哈拉形式抗菌活性的研究
Pub Date : 2023-12-30 DOI: 10.55218/jasr.2023141106
Saimeera P, Chithra G. Nair
Ayurveda categorizes various skin diseases under “kushta”, with treatments described in ancient texts like the Charaka samhitha. Among these treatments, kushtaamruthasangadi avachurnana (dusting powder) is recommended for skin conditions like dadru (tinea), kitibha (psoriasis), pama (scabies), and vicharchika (eczema), which exhibit itching, oozing, and discolouration. Avachurnana involves dusting fine powdered herbs over skin lesions. The avachurnana (dusting powder) formulation is having kushta (Saussurialappa) and amruthasanga (blue vitriol) as the first two ingredients; hence it is named as kushta amruthasangadi avachurnana. To enhance its effectiveness, this study explores transforming avachurnana (dusting powder) into a Malahara (oinment) to increase its contact duration on the skin. The research focuses on the antimicrobial properties of kushtaamruthasangadi avachurnana (dusting powder) and its Malahara (oinment) form by using agar well diffusion method against the strains streptococcus pyogens, staphylococcus aureus, aspergillus niger and candida albicans. In testing, avachurnana exhibited limited antimicrobial activity, with no impact on staphylococcus aureus and streptococcus pyogenes but showing inhibition of candida albicans. The Malahara form, tested 80% hexane, showed no impact on aspergillus niger and candida albicans but displayed some inhibition of staphylococcus aureus and streptococcus pyogens. The results suggest varying antimicrobial effectiveness against different microorganisms. Avachurnana is more potent against fungi like candida albicans and aspergillus niger, while the Malahara form shows some activity against specific bacteria. This difference could be due to the presence of sarshapataila in the Malahara, known for its antibacterial properties. In summary, this research investigates Ayurvedic treatments for skin diseases, shedding light on their antimicrobial effects and potential applications.
阿育吠陀将各种皮肤病归入 "kushta",并在 Charaka samhitha 等古籍中描述了治疗方法。在这些治疗方法中,kushtaamruthasangadi avachurnana(撒粉)被推荐用于治疗皮肤病,如dadru(癣)、kitibha(银屑病)、pama(疥疮)和vicharchika(湿疹),这些皮肤病表现出瘙痒、渗出和变色。Avachurnana 是将草药细粉撒在皮损处。avachurnana(粉末)配方的前两种成分是 kushta(Saussurialappa)和 amruthasanga(蓝矾),因此被命名为 kushta amruthasangadi avachurnana。为了提高其功效,本研究探讨了将 avachurnana(粉末)转化为 Malahara(油膏),以增加其在皮肤上的接触时间。研究重点是通过琼脂井扩散法,研究 kushtaamruthasangadi avachurnana(粉末)及其 Malahara(油膏)对化脓性链球菌、金黄色葡萄球菌、黑曲霉和白色念珠菌的抗菌特性。在测试中,avachurnana 表现出有限的抗菌活性,对金黄色葡萄球菌和化脓性链球菌没有影响,但对白色念珠菌有抑制作用。在 80% 的正己烷中测试的马拉哈拉形态对黑曲霉和白色念珠菌没有影响,但对金黄色葡萄球菌和化脓性链球菌有一定的抑制作用。结果表明,对不同微生物的抗菌效果各不相同。Avachurnana 对白色念珠菌和黑曲霉等真菌更有效,而马拉哈拉则对特定细菌有一定的活性。造成这种差异的原因可能是马拉哈拉中含有以抗菌著称的沙棘属植物。总之,这项研究调查了阿育吠陀治疗皮肤病的方法,揭示了它们的抗菌效果和潜在应用。
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引用次数: 0
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Journal of Advanced Scientific Research
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