{"title":"龙葵叶水提物与人乳腺腺癌MCF-7细胞系的细胞毒性和抗癌活性","authors":"S. Dhamodaran, Raja Kothandam, Saravanan Ramachandran","doi":"10.35652/igjps.2022.12016","DOIUrl":null,"url":null,"abstract":"Naturalherbalproducts areformulatedwitha combinationofphytoconstituentsfrom plants which play a pivotalrole becauseof their diverse medicinal properties.Limited plants have been screened for their complete biological and pharmacological nature.In the present research workan attempt wasmade to infer the medicinal value of aqueousextract of Solanumtorvum (S.torvum)leaves. Phytochemical analysis of theaqueous extracts of S.torvumleaf in the present study ascertain the presence of flavonoids, phenols, saponins, alkaloids, coumarins, sterols, proteins and reducing sugars.Further, the potentiality of aqueous extract ofS.torvumleaveswas assessedfor its cytotoxic effecton Normal Verocell lineand anticancer activityonHumanbreast adenocarcinoma cell lineby 3-(4,5dimethylthiazole-2-yl)-2,5-diphenyl tetrazoliumbromide assay.A 24-hour incubationcell proliferation studyreducedthe cell viability of MCF-7 breast cancer cell lines.In vitro studieson cytotoxicity analysis on Vero cell line revealed thattheaqueous leaf extract of S.torvumhasno toxicityand further it was foundtobeeffectiveinthepreventionofcellproliferation by MCF-7celllines.©2022iGlobal Research and PublishingFoundation. All rights reserved.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"20 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Cytotoxicity and Anticancer activity of Aqueous Leaf Extract of Solanum torvumon Normal Vero and Human Breast Adenocarcinoma MCF-7 Cell Line\",\"authors\":\"S. Dhamodaran, Raja Kothandam, Saravanan Ramachandran\",\"doi\":\"10.35652/igjps.2022.12016\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Naturalherbalproducts areformulatedwitha combinationofphytoconstituentsfrom plants which play a pivotalrole becauseof their diverse medicinal properties.Limited plants have been screened for their complete biological and pharmacological nature.In the present research workan attempt wasmade to infer the medicinal value of aqueousextract of Solanumtorvum (S.torvum)leaves. Phytochemical analysis of theaqueous extracts of S.torvumleaf in the present study ascertain the presence of flavonoids, phenols, saponins, alkaloids, coumarins, sterols, proteins and reducing sugars.Further, the potentiality of aqueous extract ofS.torvumleaveswas assessedfor its cytotoxic effecton Normal Verocell lineand anticancer activityonHumanbreast adenocarcinoma cell lineby 3-(4,5dimethylthiazole-2-yl)-2,5-diphenyl tetrazoliumbromide assay.A 24-hour incubationcell proliferation studyreducedthe cell viability of MCF-7 breast cancer cell lines.In vitro studieson cytotoxicity analysis on Vero cell line revealed thattheaqueous leaf extract of S.torvumhasno toxicityand further it was foundtobeeffectiveinthepreventionofcellproliferation by MCF-7celllines.©2022iGlobal Research and PublishingFoundation. All rights reserved.\",\"PeriodicalId\":13366,\"journal\":{\"name\":\"Indo Global Journal of Pharmaceutical Sciences\",\"volume\":\"20 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indo Global Journal of Pharmaceutical Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.35652/igjps.2022.12016\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indo Global Journal of Pharmaceutical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.35652/igjps.2022.12016","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Cytotoxicity and Anticancer activity of Aqueous Leaf Extract of Solanum torvumon Normal Vero and Human Breast Adenocarcinoma MCF-7 Cell Line
Naturalherbalproducts areformulatedwitha combinationofphytoconstituentsfrom plants which play a pivotalrole becauseof their diverse medicinal properties.Limited plants have been screened for their complete biological and pharmacological nature.In the present research workan attempt wasmade to infer the medicinal value of aqueousextract of Solanumtorvum (S.torvum)leaves. Phytochemical analysis of theaqueous extracts of S.torvumleaf in the present study ascertain the presence of flavonoids, phenols, saponins, alkaloids, coumarins, sterols, proteins and reducing sugars.Further, the potentiality of aqueous extract ofS.torvumleaveswas assessedfor its cytotoxic effecton Normal Verocell lineand anticancer activityonHumanbreast adenocarcinoma cell lineby 3-(4,5dimethylthiazole-2-yl)-2,5-diphenyl tetrazoliumbromide assay.A 24-hour incubationcell proliferation studyreducedthe cell viability of MCF-7 breast cancer cell lines.In vitro studieson cytotoxicity analysis on Vero cell line revealed thattheaqueous leaf extract of S.torvumhasno toxicityand further it was foundtobeeffectiveinthepreventionofcellproliferation by MCF-7celllines.©2022iGlobal Research and PublishingFoundation. All rights reserved.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
