Fernanda Maia, Laura Ataídes, F. Conte, Rodrigo Silva
{"title":"钩端螺旋体分泌金属蛋白酶天然免疫原性b细胞表位的鉴定:钩端螺旋体病多表位疫苗的新靶点","authors":"Fernanda Maia, Laura Ataídes, F. Conte, Rodrigo Silva","doi":"10.35259/isi.2022_52271","DOIUrl":null,"url":null,"abstract":"and virulence-associated proteins. These proteins presented two (LIC13321-E1; LIC13321-E2) and four (LIC10715-E1, LIC10715-E2, LIC10715-E3, LIC10715-E4) predicted B-cell linear epitopes. Regarding the natural immunogenicity of predicted epitopes, about 8% and 25% of LG presented antibodies against LIC13321-E1 and LIC13321-E2, respectively. Moreover, while only 6% of LG presented antibodies against LIC10715-E2, other LIC10715 epitopes were specifically recognized by more than 25% of studied individuals. Conclusion: Four naturally immunogenic B-cell epitopes were identified in Leptospira thermolysins and will be evaluated about their protective potential to further compose novel multi-epitopes vaccines.","PeriodicalId":8089,"journal":{"name":"Annals of the symposium: vaccines, biopharmaceuticals, in vitro diagnosis, management, other related themes","volume":"2013 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Identification of naturally immunogenic B-cell epitopes in Leptospira secreted metalloproteases: novel and promising targets to multi-epitopes vaccines against leptospirosis\",\"authors\":\"Fernanda Maia, Laura Ataídes, F. Conte, Rodrigo Silva\",\"doi\":\"10.35259/isi.2022_52271\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"and virulence-associated proteins. These proteins presented two (LIC13321-E1; LIC13321-E2) and four (LIC10715-E1, LIC10715-E2, LIC10715-E3, LIC10715-E4) predicted B-cell linear epitopes. Regarding the natural immunogenicity of predicted epitopes, about 8% and 25% of LG presented antibodies against LIC13321-E1 and LIC13321-E2, respectively. Moreover, while only 6% of LG presented antibodies against LIC10715-E2, other LIC10715 epitopes were specifically recognized by more than 25% of studied individuals. Conclusion: Four naturally immunogenic B-cell epitopes were identified in Leptospira thermolysins and will be evaluated about their protective potential to further compose novel multi-epitopes vaccines.\",\"PeriodicalId\":8089,\"journal\":{\"name\":\"Annals of the symposium: vaccines, biopharmaceuticals, in vitro diagnosis, management, other related themes\",\"volume\":\"2013 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of the symposium: vaccines, biopharmaceuticals, in vitro diagnosis, management, other related themes\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.35259/isi.2022_52271\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of the symposium: vaccines, biopharmaceuticals, in vitro diagnosis, management, other related themes","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.35259/isi.2022_52271","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Identification of naturally immunogenic B-cell epitopes in Leptospira secreted metalloproteases: novel and promising targets to multi-epitopes vaccines against leptospirosis
and virulence-associated proteins. These proteins presented two (LIC13321-E1; LIC13321-E2) and four (LIC10715-E1, LIC10715-E2, LIC10715-E3, LIC10715-E4) predicted B-cell linear epitopes. Regarding the natural immunogenicity of predicted epitopes, about 8% and 25% of LG presented antibodies against LIC13321-E1 and LIC13321-E2, respectively. Moreover, while only 6% of LG presented antibodies against LIC10715-E2, other LIC10715 epitopes were specifically recognized by more than 25% of studied individuals. Conclusion: Four naturally immunogenic B-cell epitopes were identified in Leptospira thermolysins and will be evaluated about their protective potential to further compose novel multi-epitopes vaccines.
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