亚致死浓度的金属氧化物纳米颗粒与大块(Al2O3、CuO和SiO2)混合物对加里平Clarias gariepinus鳃组织的拮抗作用

IF 3.9 Q2 NANOSCIENCE & NANOTECHNOLOGY Journal of Nanotechnology Pub Date : 2019-06-12 DOI:10.1155/2019/7686597
A. H. Nnamdi, T. Briggs, Oluwaseun Olusola Togunde, H. Obanya
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引用次数: 7

摘要

背景。纳米颗粒(NPs)对水生环境的影响研究较少。的目标。本研究利用组织学生物标志物评估了这些不同金属纳米颗粒及其混合物(Al2O3、CuO和SiO2)的联合效应对鱼类的毒性。材料与方法。使用了三种盐(Al2O3, CuO和SiO2)的体积和纳米尺寸。纳米尺寸从25纳米到100纳米不等。鱼幼鱼平均体长:12.3±3.5 cm;平均体重:18.52±6.41 g)进行急、慢性毒性试验。他们分别暴露在7毫克/升的体积和纳米尺寸的三种金属氧化物中,无论是单独的还是混合的,持续28天。亚致死浓度的依据是,三种不同大小的金属氧化物的96小时急性毒性直到100毫克/升的浓度都是无毒的,在最高暴露浓度下没有明显的死亡率。收集鳃进行组织病理学检查。结果。三种金属氧化物纳米颗粒中,SiO毒性最大,其组织病理学改变指数(HAI)为20.0,其次是纳米cuo (HAI, 10.0)和纳米al2o3 (HAI, 2.0)。单次暴露时,鳃的改变包括鳃片糜烂(EGL)、增厚(HPT)、水肿(OD)和坏死(N)的频率较高。SiO + Al2O3、SiO + CuO和SiO + Al2O3 + CuO等金属氧化物纳米颗粒(1∶1 - hai、2和6)组合时,观察到的损伤较小;1:1 - 1 - hai, 6)和不等比(1:1 - 2-HAI, 16和6;同样,除了等比的大块CuO (HAI, 20)和大块Al2O3 (HAI, 10)在HAI为32时具有加性作用外,所有大块组合也具有拮抗作用。结论。纳米Al2O3和CuO与SiO的联合作用产生了低毒性效应,而不是它们单独试验的高毒性;这也表明纳米Al2O3和CuO是拮抗剂。同样,在大块金属氧化物(SiO、Al2O3和CuO)中,CuO的毒性最大。体积SiO和Al2O3对CuO对鱼鳃的影响具有拮抗作用。有必要适当地记录纳米颗粒在水生环境中的生态影响。
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Antagonistic Effects of Sublethal Concentrations of Certain Mixtures of Metal Oxide Nanoparticles and the Bulk (Al2O3, CuO, and SiO2) on Gill Histology in Clarias gariepinus
Background. The effect of nanoparticles (NPs) on aquatic environments is poorly studied. Aim. This study evaluates the toxicity of joint effects of these different metal nanoparticles and their bulk in mixtures (Al2O3, CuO, and SiO2) on fish using histological biomarker. Materials and Methods. The bulk and nano sizes of three salts (Al2O3, CuO, and SiO2) were used. Nanosizes ranged from 25 nm to 100 nm. The juvenile fishes of Clarias gariepinus (mean Length: 12.3 ± 3.5 cm; mean weight: 18.52 ± 6.41 g) were used for the acute and chronic toxicity tests. They were exposed to 7 mg/L each of the bulk and nano sizes of the three metallic oxides either singly or in mixtures for 28 days. The basis for the sublethal concentration was that the 96 hr acute toxicity of the varied sizes of the three metallic oxides was nontoxic up to the concentrations of 100 mg/L with no significant mortality at the highest exposure concentrations. The gills were collected for histopathology. Results. Of the three metal oxide nanoparticles, SiO was the most toxic, with histopathological alteration index (HAI) of 20.0, followed by nano-CuO (HAI, 10.0) and nano-Al2O3 (HAI, 2.0). In single exposure, the gill alterations include high frequencies of erosion of gill lamella (EGL), hypertrophy (HPT), oedema (OD), and necrosis (N). Less damage was observed at the combination of the metal oxide nanoparticles of SiO + Al2O3, SiO + CuO and SiO + Al2O3 + CuO in equal (1 : 1—HAI, 2 and 6; 1 : 1 : 1—HAI, 6) and unequal ratios (1 : 2—HAI, 16 and 6; 2 : 1—HAI, 8 and 6). Similarly, all bulk combinations were also antagonistic except for the equal ratio of bulk CuO (HAI, 20) and bulk Al2O3 (HAI, 10) that gave additive effect with HAI of 32. Conclusion. The joint actions of nano Al2O3 and CuO with SiO produced a low toxic effect, unlike the high toxicity of their single trials; this also indicates that nano Al2O3 and CuO are antagonists. Similarly, among the bulk metal oxides (SiO, Al2O3, and CuO), CuO was the most toxic. Bulk SiO and Al2O3 are antagonistic on the effects of CuO on the fish gill. There is need to properly document the ecological implications of nanoparticles in the aquatic environment.
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来源期刊
Journal of Nanotechnology
Journal of Nanotechnology NANOSCIENCE & NANOTECHNOLOGY-
CiteScore
5.50
自引率
2.40%
发文量
25
审稿时长
13 weeks
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