无创血糖测量系统的设计与开发

Brince Paul, Melvin P. Manuel, Z. C. Alex
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引用次数: 49

摘要

糖尿病是21世纪最大的健康挑战之一,因为糖尿病患者在20-79岁年龄组呈指数增长。为防止糖尿病并发症的发生,对血糖水平进行持续监测是必要的。大多数常规葡萄糖测量系统本质上是侵入性的。侵入性方法存在疼痛、费时、费用高、传播传染病的潜在风险。因此,需要一种可靠、经济、舒适的无创血糖连续检测系统。所提出的方法是基于葡萄糖对器官散射特性的直接影响。葡萄糖降低了散射体与其周围介质之间的折射率不匹配,导致散射系数更小,因此光程更短。散射的减少是由于葡萄糖浓度的增加。因此,随着葡萄糖浓度的增加,吸收的光子减少,光强增加。在本研究中,我们采用了PPG技术。根据PPG数据开发了一种用于监测血糖的算法。与ARKRAY、Glucocard tm01-mini进行比较,结果吻合较好。
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Design and development of non invasive glucose measurement system
One of the biggest health challenges of 21st century is diabetics due to its exponential increase in the diabetics patients in the age group of 20–79 years. To prevent the complication due to diabetics it is essential to monitor the blood glucose level continuously. Most of the regular glucose measurement systems are invasive in nature. Invasive methods cause pain, time consumption, high cost and potential risk of spreading infection diseases. Therefore there is a great demand to have reliable cost effective and comfortable non invasive system for the detection of blood glucose level continuously. The proposed method is based on the direct effect of glucose on the scattering properties of the organ. Glucose decreases the mismatch in refractive index between scatterers and their surrounding media, leading to a smaller scattering coefficient and, consequently, a shorter optical path. The reduction in scattering is due to an increase in glucose concentration. As a result, with the growing concentration of glucose, fewer photons are absorbed and the light intensity increases. In the present work, we have used PPG technique. An algorithm was developed from the PPG data for monitoring blood glucose. The result obtained from this technique was compared with ARKRAY, Glucocard tm01-mini and found good agreement.
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