基于患者状态的药物相互作用预测模型的建立

N. A. Al-Majmar, Ayedh abdulaziz Mohsen, Mohammed Sharaf Al-Thulathi
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引用次数: 0

摘要

药物相互作用预测是药物生产和使用中的健康关键问题之一。提出一种能够对药物相互作用进行高精度分类和预测的计算模型是一个难题。药物分为两类:重叠和非重叠。在仅选择成人类别的情况下,根据药物的有效剂量、最大剂量、每日使用次数、患者年龄等多种信息、干扰原因以及患者与原料药之间引起干扰的常见因素,建议建立药物相互作用分类和预测专家系统。本文提出的模型可以通过患者的状态对药物的相互作用进行分类和预测,同时考虑到当改变上述因素之一时,药物的效果会发生变化,可能导致患者出现新的症状。有一个与上述模型相关的桌面应用程序,它可以帮助用户了解药物和药物家族及其相互作用。提出的模型将在Python中使用以下分类器实现:逻辑回归(LR),支持向量机(SVM)和神经网络(NN),它们根据与药物干扰发生因素相关的相似性对数据进行划分。由于这些技术显示出良好的结果,因此NN技术被认为是给出结果的最佳技术之一,其中MLPClassifier达到了97.12%的优异性能。
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Development a Model for Drug Interaction Prediction Based on Patient State
Drug interactions prediction is one of the health critical issues in drug producing and use. Proposing computational model for classifying and predicting interactions of drugs with high precision is a difficult problem. Medicines are classified into two classes: overlapping, non-overlapping. It was suggested an expert system for classifying and predicting interactions of drugs using various information about drugs, interference reasons and common factors between patients and active substance that causes interference, such as: effective dose of the drug, maximum dose, times of use per day and age of patients considering that only adult category selected. The proposed model can classify and predict interactions of drugs through patient's state taking into consideration that when changing one of mentioned factors, the effect of drugs will be changed and it may lead to appear new symptoms on the patients. There is a desktop application related with the mentioned model, which helps users to know drugs and drugs families and its interactions. Proposed model will be implemented in Python using following classifiers: Logistic Regression (LR), Support Vector Machine (SVM) and Neural Network (NN), which divided data according to their similarity related to the factors of occurrence of drug interference. As these techniques showed good results, NN technology is considered one of the best techniques in giving results where MLPClassifier achieved superior performance with 97.12%.
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来源期刊
International Journal of Intelligent Systems and Applications in Engineering
International Journal of Intelligent Systems and Applications in Engineering Computer Science-Computer Graphics and Computer-Aided Design
CiteScore
1.30
自引率
0.00%
发文量
18
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