{"title":"毛蕊花α-葡萄糖苷酶抑制及自由基清除成分研究。","authors":"Sridhar Rao Ayinampudi","doi":"10.1016/j.jopr.2013.08.013","DOIUrl":null,"url":null,"abstract":"<div><p>A bioassay-guided fractionation and chemical investigation of the whole plant of <em>Premna tomentosa</em> resulted in the isolation and characterization of premnalin (<strong>1</strong>), along with the known compounds coniferaldehyde (<strong>2</strong>), syrangaldehyde (<strong>3</strong>), acetoxy syrangaldehyde (<strong>4</strong>), lupeol (<strong>5</strong>), betulin (<strong>6</strong>), 2-(4-methoxyphenyl)-2-butanone (<strong>7</strong>), icetexatriene-1 (<strong>8</strong>), icetexatriene-2 (<strong>9</strong>). Their structures were established on the basis of extensive spectroscopic such as (IR, MS, 2D NMR) data analysis and by comparison with the spectroscopic data reported in the literature, premnalin (IC<sub>50</sub>: 12.11 μg/mL) & (SC<sub>50</sub>: 20.58 μg/mL), acetoxy syrangaldehyde (IC<sub>50</sub>: 18.41 μg/mL) & (SC<sub>50</sub>: 20.83 μg/mL) displayed potent α-glucosidase inhibition and free radical scavengers (DPPH).</p></div>","PeriodicalId":16787,"journal":{"name":"Journal of Pharmacy Research","volume":"6 8","pages":"Pages 893-896"},"PeriodicalIF":0.0000,"publicationDate":"2013-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jopr.2013.08.013","citationCount":"2","resultStr":"{\"title\":\"α-Glucosidase enzyme inhibitory and free radical scavenging constituents from Premna tomentosa Linn.\",\"authors\":\"Sridhar Rao Ayinampudi\",\"doi\":\"10.1016/j.jopr.2013.08.013\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A bioassay-guided fractionation and chemical investigation of the whole plant of <em>Premna tomentosa</em> resulted in the isolation and characterization of premnalin (<strong>1</strong>), along with the known compounds coniferaldehyde (<strong>2</strong>), syrangaldehyde (<strong>3</strong>), acetoxy syrangaldehyde (<strong>4</strong>), lupeol (<strong>5</strong>), betulin (<strong>6</strong>), 2-(4-methoxyphenyl)-2-butanone (<strong>7</strong>), icetexatriene-1 (<strong>8</strong>), icetexatriene-2 (<strong>9</strong>). Their structures were established on the basis of extensive spectroscopic such as (IR, MS, 2D NMR) data analysis and by comparison with the spectroscopic data reported in the literature, premnalin (IC<sub>50</sub>: 12.11 μg/mL) & (SC<sub>50</sub>: 20.58 μg/mL), acetoxy syrangaldehyde (IC<sub>50</sub>: 18.41 μg/mL) & (SC<sub>50</sub>: 20.83 μg/mL) displayed potent α-glucosidase inhibition and free radical scavengers (DPPH).</p></div>\",\"PeriodicalId\":16787,\"journal\":{\"name\":\"Journal of Pharmacy Research\",\"volume\":\"6 8\",\"pages\":\"Pages 893-896\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.jopr.2013.08.013\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Pharmacy Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0974694313003332\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pharmacy Research","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0974694313003332","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
α-Glucosidase enzyme inhibitory and free radical scavenging constituents from Premna tomentosa Linn.
A bioassay-guided fractionation and chemical investigation of the whole plant of Premna tomentosa resulted in the isolation and characterization of premnalin (1), along with the known compounds coniferaldehyde (2), syrangaldehyde (3), acetoxy syrangaldehyde (4), lupeol (5), betulin (6), 2-(4-methoxyphenyl)-2-butanone (7), icetexatriene-1 (8), icetexatriene-2 (9). Their structures were established on the basis of extensive spectroscopic such as (IR, MS, 2D NMR) data analysis and by comparison with the spectroscopic data reported in the literature, premnalin (IC50: 12.11 μg/mL) & (SC50: 20.58 μg/mL), acetoxy syrangaldehyde (IC50: 18.41 μg/mL) & (SC50: 20.83 μg/mL) displayed potent α-glucosidase inhibition and free radical scavengers (DPPH).
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